Mechanical property characterization of prostate cancer using a minimally motorized indenter in an ex vivo indentation experiment

Bum Mo Ahn, Jung Kim, Lorenzo Ian, Kun Ho Rha, Hyung Joo Kim

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

OBJECTIVES: To measure the mechanical property of prostatic tissues using a minimally motorized indenter and to determine whether measurable differences in mechanical property exist between cancerous and noncancerous tissues in an ex vivo experiment. METHODS: A total of 552 sites from 46 prostate specimens taken during radical prostatectomy underwent an indentation experiment with a minimally motorized indenter, and the elastic modulus (Young's modulus) of the tissue was estimated. RESULTS: The mean elastic modulus of the regions containing cancer and noncancer was 24.1 ± 14.5 and 17.0 ± 9.0 kPa, respectively. In the noncancerous regions, the prostate was separated into 5 parts according to the post hoc test for comparing the elastic modulus between the 2 groups: part 1, lateral apex; part 2, medial apex; part 3, lateral-mid; part 4, lateral base; and part 5, medial-mid and medial base. In the regions containing cancer tissue, the prostate was also separated into 5 parts: part 1, lateral apex and medial apex; part 2, lateral-mid; part 3, lateral base; part 4, medial base; and part 5, medial-mid. The elastic modulus was greater in the tissue with a Gleason score of 8 than in the other tissue. The elastic modulus was significantly greater in the tissue with a tumor volume >5 cm3 than in the other tissue. CONCLUSIONS: We determined the elastic moduli of prostatic tissue as a quantitative and objective parameter according to the regions of the prostate, the presence of cancerous tissue, the tumor volume, and the Gleason score.

Original languageEnglish
Pages (from-to)1007-1011
Number of pages5
JournalUrology
Volume76
Issue number4
DOIs
Publication statusPublished - 2010 Oct 1

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Prostatic Neoplasms
Elastic Modulus
Prostate
Neoplasm Grading
Tumor Burden
Prostatectomy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Ahn, Bum Mo ; Kim, Jung ; Ian, Lorenzo ; Rha, Kun Ho ; Kim, Hyung Joo. / Mechanical property characterization of prostate cancer using a minimally motorized indenter in an ex vivo indentation experiment. In: Urology. 2010 ; Vol. 76, No. 4. pp. 1007-1011.
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Mechanical property characterization of prostate cancer using a minimally motorized indenter in an ex vivo indentation experiment. / Ahn, Bum Mo; Kim, Jung; Ian, Lorenzo; Rha, Kun Ho; Kim, Hyung Joo.

In: Urology, Vol. 76, No. 4, 01.10.2010, p. 1007-1011.

Research output: Contribution to journalArticle

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AU - Rha, Kun Ho

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N2 - OBJECTIVES: To measure the mechanical property of prostatic tissues using a minimally motorized indenter and to determine whether measurable differences in mechanical property exist between cancerous and noncancerous tissues in an ex vivo experiment. METHODS: A total of 552 sites from 46 prostate specimens taken during radical prostatectomy underwent an indentation experiment with a minimally motorized indenter, and the elastic modulus (Young's modulus) of the tissue was estimated. RESULTS: The mean elastic modulus of the regions containing cancer and noncancer was 24.1 ± 14.5 and 17.0 ± 9.0 kPa, respectively. In the noncancerous regions, the prostate was separated into 5 parts according to the post hoc test for comparing the elastic modulus between the 2 groups: part 1, lateral apex; part 2, medial apex; part 3, lateral-mid; part 4, lateral base; and part 5, medial-mid and medial base. In the regions containing cancer tissue, the prostate was also separated into 5 parts: part 1, lateral apex and medial apex; part 2, lateral-mid; part 3, lateral base; part 4, medial base; and part 5, medial-mid. The elastic modulus was greater in the tissue with a Gleason score of 8 than in the other tissue. The elastic modulus was significantly greater in the tissue with a tumor volume >5 cm3 than in the other tissue. CONCLUSIONS: We determined the elastic moduli of prostatic tissue as a quantitative and objective parameter according to the regions of the prostate, the presence of cancerous tissue, the tumor volume, and the Gleason score.

AB - OBJECTIVES: To measure the mechanical property of prostatic tissues using a minimally motorized indenter and to determine whether measurable differences in mechanical property exist between cancerous and noncancerous tissues in an ex vivo experiment. METHODS: A total of 552 sites from 46 prostate specimens taken during radical prostatectomy underwent an indentation experiment with a minimally motorized indenter, and the elastic modulus (Young's modulus) of the tissue was estimated. RESULTS: The mean elastic modulus of the regions containing cancer and noncancer was 24.1 ± 14.5 and 17.0 ± 9.0 kPa, respectively. In the noncancerous regions, the prostate was separated into 5 parts according to the post hoc test for comparing the elastic modulus between the 2 groups: part 1, lateral apex; part 2, medial apex; part 3, lateral-mid; part 4, lateral base; and part 5, medial-mid and medial base. In the regions containing cancer tissue, the prostate was also separated into 5 parts: part 1, lateral apex and medial apex; part 2, lateral-mid; part 3, lateral base; part 4, medial base; and part 5, medial-mid. The elastic modulus was greater in the tissue with a Gleason score of 8 than in the other tissue. The elastic modulus was significantly greater in the tissue with a tumor volume >5 cm3 than in the other tissue. CONCLUSIONS: We determined the elastic moduli of prostatic tissue as a quantitative and objective parameter according to the regions of the prostate, the presence of cancerous tissue, the tumor volume, and the Gleason score.

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