Abstract
OBJECTIVES: To measure the mechanical property of prostatic tissues using a minimally motorized indenter and to determine whether measurable differences in mechanical property exist between cancerous and noncancerous tissues in an ex vivo experiment. METHODS: A total of 552 sites from 46 prostate specimens taken during radical prostatectomy underwent an indentation experiment with a minimally motorized indenter, and the elastic modulus (Young's modulus) of the tissue was estimated. RESULTS: The mean elastic modulus of the regions containing cancer and noncancer was 24.1 ± 14.5 and 17.0 ± 9.0 kPa, respectively. In the noncancerous regions, the prostate was separated into 5 parts according to the post hoc test for comparing the elastic modulus between the 2 groups: part 1, lateral apex; part 2, medial apex; part 3, lateral-mid; part 4, lateral base; and part 5, medial-mid and medial base. In the regions containing cancer tissue, the prostate was also separated into 5 parts: part 1, lateral apex and medial apex; part 2, lateral-mid; part 3, lateral base; part 4, medial base; and part 5, medial-mid. The elastic modulus was greater in the tissue with a Gleason score of 8 than in the other tissue. The elastic modulus was significantly greater in the tissue with a tumor volume >5 cm3 than in the other tissue. CONCLUSIONS: We determined the elastic moduli of prostatic tissue as a quantitative and objective parameter according to the regions of the prostate, the presence of cancerous tissue, the tumor volume, and the Gleason score.
| Original language | English |
|---|---|
| Pages (from-to) | 1007-1011 |
| Number of pages | 5 |
| Journal | Urology |
| Volume | 76 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2010 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Urology
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Mechanical property characterization of prostate cancer using a minimally motorized indenter in an ex vivo indentation experiment. / Ahn, Bum Mo; Kim, Jung; Ian, Lorenzo; Rha, Kun Ho; Kim, Hyung Joo.
In: Urology, Vol. 76, No. 4, 01.10.2010, p. 1007-1011.Research output: Contribution to journal › Article
TY - JOUR
T1 - Mechanical property characterization of prostate cancer using a minimally motorized indenter in an ex vivo indentation experiment
AU - Ahn, Bum Mo
AU - Kim, Jung
AU - Ian, Lorenzo
AU - Rha, Kun Ho
AU - Kim, Hyung Joo
PY - 2010/10/1
Y1 - 2010/10/1
N2 - OBJECTIVES: To measure the mechanical property of prostatic tissues using a minimally motorized indenter and to determine whether measurable differences in mechanical property exist between cancerous and noncancerous tissues in an ex vivo experiment. METHODS: A total of 552 sites from 46 prostate specimens taken during radical prostatectomy underwent an indentation experiment with a minimally motorized indenter, and the elastic modulus (Young's modulus) of the tissue was estimated. RESULTS: The mean elastic modulus of the regions containing cancer and noncancer was 24.1 ± 14.5 and 17.0 ± 9.0 kPa, respectively. In the noncancerous regions, the prostate was separated into 5 parts according to the post hoc test for comparing the elastic modulus between the 2 groups: part 1, lateral apex; part 2, medial apex; part 3, lateral-mid; part 4, lateral base; and part 5, medial-mid and medial base. In the regions containing cancer tissue, the prostate was also separated into 5 parts: part 1, lateral apex and medial apex; part 2, lateral-mid; part 3, lateral base; part 4, medial base; and part 5, medial-mid. The elastic modulus was greater in the tissue with a Gleason score of 8 than in the other tissue. The elastic modulus was significantly greater in the tissue with a tumor volume >5 cm3 than in the other tissue. CONCLUSIONS: We determined the elastic moduli of prostatic tissue as a quantitative and objective parameter according to the regions of the prostate, the presence of cancerous tissue, the tumor volume, and the Gleason score.
AB - OBJECTIVES: To measure the mechanical property of prostatic tissues using a minimally motorized indenter and to determine whether measurable differences in mechanical property exist between cancerous and noncancerous tissues in an ex vivo experiment. METHODS: A total of 552 sites from 46 prostate specimens taken during radical prostatectomy underwent an indentation experiment with a minimally motorized indenter, and the elastic modulus (Young's modulus) of the tissue was estimated. RESULTS: The mean elastic modulus of the regions containing cancer and noncancer was 24.1 ± 14.5 and 17.0 ± 9.0 kPa, respectively. In the noncancerous regions, the prostate was separated into 5 parts according to the post hoc test for comparing the elastic modulus between the 2 groups: part 1, lateral apex; part 2, medial apex; part 3, lateral-mid; part 4, lateral base; and part 5, medial-mid and medial base. In the regions containing cancer tissue, the prostate was also separated into 5 parts: part 1, lateral apex and medial apex; part 2, lateral-mid; part 3, lateral base; part 4, medial base; and part 5, medial-mid. The elastic modulus was greater in the tissue with a Gleason score of 8 than in the other tissue. The elastic modulus was significantly greater in the tissue with a tumor volume >5 cm3 than in the other tissue. CONCLUSIONS: We determined the elastic moduli of prostatic tissue as a quantitative and objective parameter according to the regions of the prostate, the presence of cancerous tissue, the tumor volume, and the Gleason score.
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U2 - 10.1016/j.urology.2010.02.025
DO - 10.1016/j.urology.2010.02.025
M3 - Article
C2 - 20451976
AN - SCOPUS:77954963688
VL - 76
SP - 1007
EP - 1011
JO - Urology
JF - Urology
SN - 0090-4295
IS - 4
ER -