Mechanism of T cell exhaustion in a chronic environment

Hyun Tak Jin, Yun Hee Jeong, Hyo Jin Park, Sang Jun Ha

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

T cell exhaustion develops under conditions of antigenpersistence caused by infection with various chronic pathogens, such as human immunodeficiency virus (HIV) and mycobacterium tuberculosis (TB), or by the development of cancer. T cell exhaustion is characterized by stepwise and progressive loss of T cell function, which is probably the main reason for the failed immunological control of chronic pathogens and cancers. Recent observations have detailed some of the intrinsic and extrinsic factors that influence the severity of T cell exhaustion. Duration and magnitude of antigenic activation of T cells might be associated with up-regulation of inhibitory receptors, which is a major intrinsic factor of T cell exhaustion. Extrinsic factors might include the production of suppressive cytokines, T cell priming by either non-professional antigenpresenting cells (APCs) or tolerogenic dendritic cells (DCs), and alteration of regulatory T (Treg) cells. Further investigation of the cellular and molecular processes behind the development of T cell exhaustion can reveal therapeutic targets and strategies for the treatment of chronic infections and cancers. Here, we report the properties and the mechanisms of T cell exhaustion in a chronic environment.

Original languageEnglish
Pages (from-to)217-231
Number of pages15
JournalBMB reports
Volume44
Issue number4
DOIs
Publication statusPublished - 2011 Apr 1

Fingerprint

T-cells
T-Lymphocytes
Intrinsic Factor
Pathogens
Regulatory T-Lymphocytes
Neoplasms
Infection
Viruses
Mycobacterium tuberculosis
Dendritic Cells
Up-Regulation
Chemical activation
HIV
Cytokines

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Jin, Hyun Tak ; Jeong, Yun Hee ; Park, Hyo Jin ; Ha, Sang Jun. / Mechanism of T cell exhaustion in a chronic environment. In: BMB reports. 2011 ; Vol. 44, No. 4. pp. 217-231.
@article{3b3e7b1b1c754e74b6833e7be8ffb9f1,
title = "Mechanism of T cell exhaustion in a chronic environment",
abstract = "T cell exhaustion develops under conditions of antigenpersistence caused by infection with various chronic pathogens, such as human immunodeficiency virus (HIV) and mycobacterium tuberculosis (TB), or by the development of cancer. T cell exhaustion is characterized by stepwise and progressive loss of T cell function, which is probably the main reason for the failed immunological control of chronic pathogens and cancers. Recent observations have detailed some of the intrinsic and extrinsic factors that influence the severity of T cell exhaustion. Duration and magnitude of antigenic activation of T cells might be associated with up-regulation of inhibitory receptors, which is a major intrinsic factor of T cell exhaustion. Extrinsic factors might include the production of suppressive cytokines, T cell priming by either non-professional antigenpresenting cells (APCs) or tolerogenic dendritic cells (DCs), and alteration of regulatory T (Treg) cells. Further investigation of the cellular and molecular processes behind the development of T cell exhaustion can reveal therapeutic targets and strategies for the treatment of chronic infections and cancers. Here, we report the properties and the mechanisms of T cell exhaustion in a chronic environment.",
author = "Jin, {Hyun Tak} and Jeong, {Yun Hee} and Park, {Hyo Jin} and Ha, {Sang Jun}",
year = "2011",
month = "4",
day = "1",
doi = "10.5483/BMBRep.2011.44.4.217",
language = "English",
volume = "44",
pages = "217--231",
journal = "BMB Reports",
issn = "1976-6696",
publisher = "The Biochemical Society of the Republic of Korea",
number = "4",

}

Mechanism of T cell exhaustion in a chronic environment. / Jin, Hyun Tak; Jeong, Yun Hee; Park, Hyo Jin; Ha, Sang Jun.

In: BMB reports, Vol. 44, No. 4, 01.04.2011, p. 217-231.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Mechanism of T cell exhaustion in a chronic environment

AU - Jin, Hyun Tak

AU - Jeong, Yun Hee

AU - Park, Hyo Jin

AU - Ha, Sang Jun

PY - 2011/4/1

Y1 - 2011/4/1

N2 - T cell exhaustion develops under conditions of antigenpersistence caused by infection with various chronic pathogens, such as human immunodeficiency virus (HIV) and mycobacterium tuberculosis (TB), or by the development of cancer. T cell exhaustion is characterized by stepwise and progressive loss of T cell function, which is probably the main reason for the failed immunological control of chronic pathogens and cancers. Recent observations have detailed some of the intrinsic and extrinsic factors that influence the severity of T cell exhaustion. Duration and magnitude of antigenic activation of T cells might be associated with up-regulation of inhibitory receptors, which is a major intrinsic factor of T cell exhaustion. Extrinsic factors might include the production of suppressive cytokines, T cell priming by either non-professional antigenpresenting cells (APCs) or tolerogenic dendritic cells (DCs), and alteration of regulatory T (Treg) cells. Further investigation of the cellular and molecular processes behind the development of T cell exhaustion can reveal therapeutic targets and strategies for the treatment of chronic infections and cancers. Here, we report the properties and the mechanisms of T cell exhaustion in a chronic environment.

AB - T cell exhaustion develops under conditions of antigenpersistence caused by infection with various chronic pathogens, such as human immunodeficiency virus (HIV) and mycobacterium tuberculosis (TB), or by the development of cancer. T cell exhaustion is characterized by stepwise and progressive loss of T cell function, which is probably the main reason for the failed immunological control of chronic pathogens and cancers. Recent observations have detailed some of the intrinsic and extrinsic factors that influence the severity of T cell exhaustion. Duration and magnitude of antigenic activation of T cells might be associated with up-regulation of inhibitory receptors, which is a major intrinsic factor of T cell exhaustion. Extrinsic factors might include the production of suppressive cytokines, T cell priming by either non-professional antigenpresenting cells (APCs) or tolerogenic dendritic cells (DCs), and alteration of regulatory T (Treg) cells. Further investigation of the cellular and molecular processes behind the development of T cell exhaustion can reveal therapeutic targets and strategies for the treatment of chronic infections and cancers. Here, we report the properties and the mechanisms of T cell exhaustion in a chronic environment.

UR - http://www.scopus.com/inward/record.url?scp=79956046962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79956046962&partnerID=8YFLogxK

U2 - 10.5483/BMBRep.2011.44.4.217

DO - 10.5483/BMBRep.2011.44.4.217

M3 - Review article

C2 - 21524346

AN - SCOPUS:79956046962

VL - 44

SP - 217

EP - 231

JO - BMB Reports

JF - BMB Reports

SN - 1976-6696

IS - 4

ER -