Abstract
Using optical coherence tomography (OCT), the mechanisms of postintervention and 9-month luminal enlargement in drug-eluting stent in-stent restenosis (ISR) lesions treated with a drug-eluting balloon (DEB) were evaluated. A total of 42 patients with DEB-treated drug-eluting stent ISR lesions underwent serial OCT examination before intervention, after intervention, and at 9-month follow-up. Preintervention OCT-derived neointima was classified as either a homogeneous or nonhomogeneous pattern. Ten ISR lesions with homogeneous neointima were identified and compared with 32 ISR lesions with nonhomogeneous neointima. When comparing pre- and postintervention evaluations, changes in luminal cross-sectional area (CSA) were 3.4 mm 2 in ISR lesions with homogeneous neointima and 3.7 mm2 in those with nonhomogeneous neointima, respectively (p = 0.529); changes in stent CSA were 2.5 mm2 and 1.4 mm2, respectively, p = 0.004; and changes in neointimal CSA were -0.9 mm2 and -2.3 mm2, respectively, p = 0.001. At 9-month follow-up, changes in luminal CSA were -2.0 mm2 and -0.9 mm2 in ISR lesions with homogeneous and nonhomogeneous neointima, respectively (p = 0.021); in stent CSA changed by -0.2 mm2 in both groups (p = 0.851) and changes in neointimal CSA was 1.8 mm2 and 0.7 mm2, respectively (p = 0.003). At the 9-month follow-up, >50% neointimal CSA stenosis was observed in 60% and 19% of the ISR lesions with homogeneous and nonhomogeneous neointima, respectively (p = 0.020). In conclusion, the mechanism of postintervention luminal enlargement by DEB varied with the preintervention OCT-based neointimal characteristics. ISR lesions with homogeneous neointima determined by OCT were associated with greater subsequent regrowth of neointima after DEB treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 1468-1473 |
| Number of pages | 6 |
| Journal | American Journal of Cardiology |
| Volume | 113 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2014 May 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
}
Mechanisms of postintervention and nine-month luminal enlargement after treatment of drug-eluting in-stent restenosis with a drug-eluting balloon. / Lee, Seung Yul; Hong, Myeong Ki; Shin, Dong Ho; Kim, Jung Sun; Kim, Byeong Keuk; Ko, Young Guk; Choi, Donghoon; Jang, Yangsoo.
In: American Journal of Cardiology, Vol. 113, No. 9, 01.05.2014, p. 1468-1473.Research output: Contribution to journal › Article
TY - JOUR
T1 - Mechanisms of postintervention and nine-month luminal enlargement after treatment of drug-eluting in-stent restenosis with a drug-eluting balloon
AU - Lee, Seung Yul
AU - Hong, Myeong Ki
AU - Shin, Dong Ho
AU - Kim, Jung Sun
AU - Kim, Byeong Keuk
AU - Ko, Young Guk
AU - Choi, Donghoon
AU - Jang, Yangsoo
PY - 2014/5/1
Y1 - 2014/5/1
N2 - Using optical coherence tomography (OCT), the mechanisms of postintervention and 9-month luminal enlargement in drug-eluting stent in-stent restenosis (ISR) lesions treated with a drug-eluting balloon (DEB) were evaluated. A total of 42 patients with DEB-treated drug-eluting stent ISR lesions underwent serial OCT examination before intervention, after intervention, and at 9-month follow-up. Preintervention OCT-derived neointima was classified as either a homogeneous or nonhomogeneous pattern. Ten ISR lesions with homogeneous neointima were identified and compared with 32 ISR lesions with nonhomogeneous neointima. When comparing pre- and postintervention evaluations, changes in luminal cross-sectional area (CSA) were 3.4 mm 2 in ISR lesions with homogeneous neointima and 3.7 mm2 in those with nonhomogeneous neointima, respectively (p = 0.529); changes in stent CSA were 2.5 mm2 and 1.4 mm2, respectively, p = 0.004; and changes in neointimal CSA were -0.9 mm2 and -2.3 mm2, respectively, p = 0.001. At 9-month follow-up, changes in luminal CSA were -2.0 mm2 and -0.9 mm2 in ISR lesions with homogeneous and nonhomogeneous neointima, respectively (p = 0.021); in stent CSA changed by -0.2 mm2 in both groups (p = 0.851) and changes in neointimal CSA was 1.8 mm2 and 0.7 mm2, respectively (p = 0.003). At the 9-month follow-up, >50% neointimal CSA stenosis was observed in 60% and 19% of the ISR lesions with homogeneous and nonhomogeneous neointima, respectively (p = 0.020). In conclusion, the mechanism of postintervention luminal enlargement by DEB varied with the preintervention OCT-based neointimal characteristics. ISR lesions with homogeneous neointima determined by OCT were associated with greater subsequent regrowth of neointima after DEB treatment.
AB - Using optical coherence tomography (OCT), the mechanisms of postintervention and 9-month luminal enlargement in drug-eluting stent in-stent restenosis (ISR) lesions treated with a drug-eluting balloon (DEB) were evaluated. A total of 42 patients with DEB-treated drug-eluting stent ISR lesions underwent serial OCT examination before intervention, after intervention, and at 9-month follow-up. Preintervention OCT-derived neointima was classified as either a homogeneous or nonhomogeneous pattern. Ten ISR lesions with homogeneous neointima were identified and compared with 32 ISR lesions with nonhomogeneous neointima. When comparing pre- and postintervention evaluations, changes in luminal cross-sectional area (CSA) were 3.4 mm 2 in ISR lesions with homogeneous neointima and 3.7 mm2 in those with nonhomogeneous neointima, respectively (p = 0.529); changes in stent CSA were 2.5 mm2 and 1.4 mm2, respectively, p = 0.004; and changes in neointimal CSA were -0.9 mm2 and -2.3 mm2, respectively, p = 0.001. At 9-month follow-up, changes in luminal CSA were -2.0 mm2 and -0.9 mm2 in ISR lesions with homogeneous and nonhomogeneous neointima, respectively (p = 0.021); in stent CSA changed by -0.2 mm2 in both groups (p = 0.851) and changes in neointimal CSA was 1.8 mm2 and 0.7 mm2, respectively (p = 0.003). At the 9-month follow-up, >50% neointimal CSA stenosis was observed in 60% and 19% of the ISR lesions with homogeneous and nonhomogeneous neointima, respectively (p = 0.020). In conclusion, the mechanism of postintervention luminal enlargement by DEB varied with the preintervention OCT-based neointimal characteristics. ISR lesions with homogeneous neointima determined by OCT were associated with greater subsequent regrowth of neointima after DEB treatment.
UR - http://www.scopus.com/inward/record.url?scp=84898837159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898837159&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2014.01.424
DO - 10.1016/j.amjcard.2014.01.424
M3 - Article
C2 - 24607028
AN - SCOPUS:84898837159
VL - 113
SP - 1468
EP - 1473
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 9
ER -