Medical resource consumption and quality of life in peripheral arterial disease in Korea: PAD outcomes (PADO) research

Seung Woon Rha, Seung Hyuk Choi, Doo Il Kim, Dong Woon Jeon, Jae Hwan Lee, Kyung Soon Hong, Tae Joon Cha, Jang Hyun Cho, Sang Kon Lee, Yong Hwan Park, Woo Jung Park, Hyun Joo Kim, Young Joo Kim, Juneyoung Lee, Donghoon Choi

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Abstract

Background and Objectives: We aimed to investigate the history of medical resource consumption and quality of life (QoL) in peripheral arterial disease (PAD) patients in Korea. Methods: This was a prospective, multi-center (23 tertiary-hospitals, division of cardiology), non-interventional study. Adult patients (age ≥20 years) suffering from PAD for the last 12-month were enrolled in the study if they met with any of following; 1) ankle-brachial index (ABI) ≤0.9, 2) lower-extremity artery stenosis on computed tomography angiography ≥50%, or 3) peak-systolic-velocity-ratio (PSVR) on ultrasound ≥2.0. Medical chart review was used to assess patient characteristics/treatment patterns while the history of medical resource consumption and QoL data were collected using a patient survey. QoL was measured using EuroQoL-5-dimensions-3-level (EQ-5D-3L) score system, and the factors associated with QoL were analyzed using multiple linear regression analysis. Results: This study included 1,260 patients (age: 69.8 years, male: 77.0%). The most prevalent comorbidities were hypertension (74.8%), hyperlipidemia (51.0%) and diabetes-mellitus (50.2%). The 94.1% of the patients took pharmacotherapy including aspirin (76.2%), clopidogrel (53.3%), and cilostazol (33.6%). The 12.6% of the patients were receiving smoking cessation education/pharmacotherapy. A considerable number of patients (500 patients, 40.0%) had visit history to another hospital before diagnosis/treatment at the current hospital, with visits to orthopedic units (50.4%) being the most common. At the time, 29% (or higher) of the patients were already experiencing symptoms of critical limb ischemia. Baseline EQ-5D index and EQ VAS were 0.64±0.24 and 67.49±18.29. Factors significantly associated with QoL were pharmacotherapy (B=0.05053; p=0.044) compared to no pharmacotherapy, and Fontaine stage improvement/maintain stage I (B=0.04448; p<0.001) compared to deterioration/maintain stage II-IV. Conclusions: Increase in disease awareness for earlier diagnosis and provision of adequate pharmacotherapy is essential to reduce disease burden and improve QoL of Korean PAD patients.

Original languageEnglish
Pages (from-to)813-825
Number of pages13
JournalKorean Circulation Journal
Volume48
Issue number9
DOIs
Publication statusPublished - 2018 Sep

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Peripheral Arterial Disease
Korea
Quality of Life
Outcome Assessment (Health Care)
Drug Therapy
clopidogrel
History
Ankle Brachial Index
Smoking Cessation
Hyperlipidemias
Cardiology
Tertiary Care Centers
Aspirin
Orthopedics
Comorbidity
Early Diagnosis
Lower Extremity
Linear Models
Diabetes Mellitus
Pathologic Constriction

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Rha, Seung Woon ; Choi, Seung Hyuk ; Kim, Doo Il ; Jeon, Dong Woon ; Lee, Jae Hwan ; Hong, Kyung Soon ; Cha, Tae Joon ; Cho, Jang Hyun ; Lee, Sang Kon ; Park, Yong Hwan ; Park, Woo Jung ; Kim, Hyun Joo ; Kim, Young Joo ; Lee, Juneyoung ; Choi, Donghoon. / Medical resource consumption and quality of life in peripheral arterial disease in Korea : PAD outcomes (PADO) research. In: Korean Circulation Journal. 2018 ; Vol. 48, No. 9. pp. 813-825.
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abstract = "Background and Objectives: We aimed to investigate the history of medical resource consumption and quality of life (QoL) in peripheral arterial disease (PAD) patients in Korea. Methods: This was a prospective, multi-center (23 tertiary-hospitals, division of cardiology), non-interventional study. Adult patients (age ≥20 years) suffering from PAD for the last 12-month were enrolled in the study if they met with any of following; 1) ankle-brachial index (ABI) ≤0.9, 2) lower-extremity artery stenosis on computed tomography angiography ≥50{\%}, or 3) peak-systolic-velocity-ratio (PSVR) on ultrasound ≥2.0. Medical chart review was used to assess patient characteristics/treatment patterns while the history of medical resource consumption and QoL data were collected using a patient survey. QoL was measured using EuroQoL-5-dimensions-3-level (EQ-5D-3L) score system, and the factors associated with QoL were analyzed using multiple linear regression analysis. Results: This study included 1,260 patients (age: 69.8 years, male: 77.0{\%}). The most prevalent comorbidities were hypertension (74.8{\%}), hyperlipidemia (51.0{\%}) and diabetes-mellitus (50.2{\%}). The 94.1{\%} of the patients took pharmacotherapy including aspirin (76.2{\%}), clopidogrel (53.3{\%}), and cilostazol (33.6{\%}). The 12.6{\%} of the patients were receiving smoking cessation education/pharmacotherapy. A considerable number of patients (500 patients, 40.0{\%}) had visit history to another hospital before diagnosis/treatment at the current hospital, with visits to orthopedic units (50.4{\%}) being the most common. At the time, 29{\%} (or higher) of the patients were already experiencing symptoms of critical limb ischemia. Baseline EQ-5D index and EQ VAS were 0.64±0.24 and 67.49±18.29. Factors significantly associated with QoL were pharmacotherapy (B=0.05053; p=0.044) compared to no pharmacotherapy, and Fontaine stage improvement/maintain stage I (B=0.04448; p<0.001) compared to deterioration/maintain stage II-IV. Conclusions: Increase in disease awareness for earlier diagnosis and provision of adequate pharmacotherapy is essential to reduce disease burden and improve QoL of Korean PAD patients.",
author = "Rha, {Seung Woon} and Choi, {Seung Hyuk} and Kim, {Doo Il} and Jeon, {Dong Woon} and Lee, {Jae Hwan} and Hong, {Kyung Soon} and Cha, {Tae Joon} and Cho, {Jang Hyun} and Lee, {Sang Kon} and Park, {Yong Hwan} and Park, {Woo Jung} and Kim, {Hyun Joo} and Kim, {Young Joo} and Juneyoung Lee and Donghoon Choi",
year = "2018",
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doi = "10.4070/kcj.2017.0340",
language = "English",
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Rha, SW, Choi, SH, Kim, DI, Jeon, DW, Lee, JH, Hong, KS, Cha, TJ, Cho, JH, Lee, SK, Park, YH, Park, WJ, Kim, HJ, Kim, YJ, Lee, J & Choi, D 2018, 'Medical resource consumption and quality of life in peripheral arterial disease in Korea: PAD outcomes (PADO) research', Korean Circulation Journal, vol. 48, no. 9, pp. 813-825. https://doi.org/10.4070/kcj.2017.0340

Medical resource consumption and quality of life in peripheral arterial disease in Korea : PAD outcomes (PADO) research. / Rha, Seung Woon; Choi, Seung Hyuk; Kim, Doo Il; Jeon, Dong Woon; Lee, Jae Hwan; Hong, Kyung Soon; Cha, Tae Joon; Cho, Jang Hyun; Lee, Sang Kon; Park, Yong Hwan; Park, Woo Jung; Kim, Hyun Joo; Kim, Young Joo; Lee, Juneyoung; Choi, Donghoon.

In: Korean Circulation Journal, Vol. 48, No. 9, 09.2018, p. 813-825.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Medical resource consumption and quality of life in peripheral arterial disease in Korea

T2 - PAD outcomes (PADO) research

AU - Rha, Seung Woon

AU - Choi, Seung Hyuk

AU - Kim, Doo Il

AU - Jeon, Dong Woon

AU - Lee, Jae Hwan

AU - Hong, Kyung Soon

AU - Cha, Tae Joon

AU - Cho, Jang Hyun

AU - Lee, Sang Kon

AU - Park, Yong Hwan

AU - Park, Woo Jung

AU - Kim, Hyun Joo

AU - Kim, Young Joo

AU - Lee, Juneyoung

AU - Choi, Donghoon

PY - 2018/9

Y1 - 2018/9

N2 - Background and Objectives: We aimed to investigate the history of medical resource consumption and quality of life (QoL) in peripheral arterial disease (PAD) patients in Korea. Methods: This was a prospective, multi-center (23 tertiary-hospitals, division of cardiology), non-interventional study. Adult patients (age ≥20 years) suffering from PAD for the last 12-month were enrolled in the study if they met with any of following; 1) ankle-brachial index (ABI) ≤0.9, 2) lower-extremity artery stenosis on computed tomography angiography ≥50%, or 3) peak-systolic-velocity-ratio (PSVR) on ultrasound ≥2.0. Medical chart review was used to assess patient characteristics/treatment patterns while the history of medical resource consumption and QoL data were collected using a patient survey. QoL was measured using EuroQoL-5-dimensions-3-level (EQ-5D-3L) score system, and the factors associated with QoL were analyzed using multiple linear regression analysis. Results: This study included 1,260 patients (age: 69.8 years, male: 77.0%). The most prevalent comorbidities were hypertension (74.8%), hyperlipidemia (51.0%) and diabetes-mellitus (50.2%). The 94.1% of the patients took pharmacotherapy including aspirin (76.2%), clopidogrel (53.3%), and cilostazol (33.6%). The 12.6% of the patients were receiving smoking cessation education/pharmacotherapy. A considerable number of patients (500 patients, 40.0%) had visit history to another hospital before diagnosis/treatment at the current hospital, with visits to orthopedic units (50.4%) being the most common. At the time, 29% (or higher) of the patients were already experiencing symptoms of critical limb ischemia. Baseline EQ-5D index and EQ VAS were 0.64±0.24 and 67.49±18.29. Factors significantly associated with QoL were pharmacotherapy (B=0.05053; p=0.044) compared to no pharmacotherapy, and Fontaine stage improvement/maintain stage I (B=0.04448; p<0.001) compared to deterioration/maintain stage II-IV. Conclusions: Increase in disease awareness for earlier diagnosis and provision of adequate pharmacotherapy is essential to reduce disease burden and improve QoL of Korean PAD patients.

AB - Background and Objectives: We aimed to investigate the history of medical resource consumption and quality of life (QoL) in peripheral arterial disease (PAD) patients in Korea. Methods: This was a prospective, multi-center (23 tertiary-hospitals, division of cardiology), non-interventional study. Adult patients (age ≥20 years) suffering from PAD for the last 12-month were enrolled in the study if they met with any of following; 1) ankle-brachial index (ABI) ≤0.9, 2) lower-extremity artery stenosis on computed tomography angiography ≥50%, or 3) peak-systolic-velocity-ratio (PSVR) on ultrasound ≥2.0. Medical chart review was used to assess patient characteristics/treatment patterns while the history of medical resource consumption and QoL data were collected using a patient survey. QoL was measured using EuroQoL-5-dimensions-3-level (EQ-5D-3L) score system, and the factors associated with QoL were analyzed using multiple linear regression analysis. Results: This study included 1,260 patients (age: 69.8 years, male: 77.0%). The most prevalent comorbidities were hypertension (74.8%), hyperlipidemia (51.0%) and diabetes-mellitus (50.2%). The 94.1% of the patients took pharmacotherapy including aspirin (76.2%), clopidogrel (53.3%), and cilostazol (33.6%). The 12.6% of the patients were receiving smoking cessation education/pharmacotherapy. A considerable number of patients (500 patients, 40.0%) had visit history to another hospital before diagnosis/treatment at the current hospital, with visits to orthopedic units (50.4%) being the most common. At the time, 29% (or higher) of the patients were already experiencing symptoms of critical limb ischemia. Baseline EQ-5D index and EQ VAS were 0.64±0.24 and 67.49±18.29. Factors significantly associated with QoL were pharmacotherapy (B=0.05053; p=0.044) compared to no pharmacotherapy, and Fontaine stage improvement/maintain stage I (B=0.04448; p<0.001) compared to deterioration/maintain stage II-IV. Conclusions: Increase in disease awareness for earlier diagnosis and provision of adequate pharmacotherapy is essential to reduce disease burden and improve QoL of Korean PAD patients.

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