Megastigmane Glycosides from Docynia indica and Their Anti-inflammatory Activities

Hoang Viet Dung, Nguyen Van Bach, Trinh Nam Trung, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem, Seon Ju Park, Taek Hwan Lee, Sun Yeou Kim, Seung Hyun Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Using various chromatographic methods, three new megastigmane glycosides, docynicasides A – C (1 – 3) and ten known, (6S,9R)-vomifoliol 9-O-β-d-xylopyranosyl-(1′′→6′)-O-β-d-glucopyranoside (4), hyperin (5), quercitrin (6), quercetin 3-α-l-arabinofuranoside (7), naringenin 7-O-β-d-glucopyranoside (8), phloridzin (9), phloretin 2′-O-β-d-xylopyranosyl-(1→6)-β-d-glucopyranoside (10), pinosylvin 3-O-β-d-glucopyranoside (11), tormentic acid (12), and chlorogenic acid methyl ester (13) were isolated from the fruits of Docynia indica. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for the inhibitory activity on NO production in LPS-stimulated BV2 cells. As the results, compounds 3 – 5 showed significant inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50values ranging from 21.0 to 29.3 μm.

Original languageEnglish
Pages (from-to)681-686
Number of pages6
JournalHelvetica Chimica Acta
Volume99
Issue number9
DOIs
Publication statusPublished - 2016 Jan 1

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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  • Cite this

    Dung, H. V., Bach, N. V., Trung, T. N., Nhiem, N. X., Tai, B. H., Kiem, P. V., Park, S. J., Lee, T. H., Kim, S. Y., & Kim, S. H. (2016). Megastigmane Glycosides from Docynia indica and Their Anti-inflammatory Activities. Helvetica Chimica Acta, 99(9), 681-686. https://doi.org/10.1002/hlca.201600125