Megastigmane Glycosides from Docynia indica and Their Anti-inflammatory Activities

Hoang Viet Dung, Nguyen Van Bach, Trinh Nam Trung, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem, Seon Ju Park, Taek Hwan Lee, Sun Yeou Kim, Seung Hyun Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Using various chromatographic methods, three new megastigmane glycosides, docynicasides A – C (1 – 3) and ten known, (6S,9R)-vomifoliol 9-O-β-d-xylopyranosyl-(1′′→6′)-O-β-d-glucopyranoside (4), hyperin (5), quercitrin (6), quercetin 3-α-l-arabinofuranoside (7), naringenin 7-O-β-d-glucopyranoside (8), phloridzin (9), phloretin 2′-O-β-d-xylopyranosyl-(1→6)-β-d-glucopyranoside (10), pinosylvin 3-O-β-d-glucopyranoside (11), tormentic acid (12), and chlorogenic acid methyl ester (13) were isolated from the fruits of Docynia indica. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for the inhibitory activity on NO production in LPS-stimulated BV2 cells. As the results, compounds 3 – 5 showed significant inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC 50 values ranging from 21.0 to 29.3 μm.

Original languageEnglish
Pages (from-to)681-686
Number of pages6
JournalHelvetica Chimica Acta
Volume99
Issue number9
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Glycosides
glucosides
Anti-Inflammatory Agents
Phloretin
Phlorhizin
Chlorogenic Acid
acids
Acids
fruits
Quercetin
Fruits
cells
esters
Fruit
alternating current
Esters
megastigmane
vomifoliol
naringenin
quercitrin

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Dung, H. V., Bach, N. V., Trung, T. N., Nhiem, N. X., Tai, B. H., Kiem, P. V., ... Kim, S. H. (2016). Megastigmane Glycosides from Docynia indica and Their Anti-inflammatory Activities. Helvetica Chimica Acta, 99(9), 681-686. https://doi.org/10.1002/hlca.201600125
Dung, Hoang Viet ; Bach, Nguyen Van ; Trung, Trinh Nam ; Nhiem, Nguyen Xuan ; Tai, Bui Huu ; Kiem, Phan Van ; Park, Seon Ju ; Lee, Taek Hwan ; Kim, Sun Yeou ; Kim, Seung Hyun. / Megastigmane Glycosides from Docynia indica and Their Anti-inflammatory Activities. In: Helvetica Chimica Acta. 2016 ; Vol. 99, No. 9. pp. 681-686.
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Dung, HV, Bach, NV, Trung, TN, Nhiem, NX, Tai, BH, Kiem, PV, Park, SJ, Lee, TH, Kim, SY & Kim, SH 2016, 'Megastigmane Glycosides from Docynia indica and Their Anti-inflammatory Activities', Helvetica Chimica Acta, vol. 99, no. 9, pp. 681-686. https://doi.org/10.1002/hlca.201600125

Megastigmane Glycosides from Docynia indica and Their Anti-inflammatory Activities. / Dung, Hoang Viet; Bach, Nguyen Van; Trung, Trinh Nam; Nhiem, Nguyen Xuan; Tai, Bui Huu; Kiem, Phan Van; Park, Seon Ju; Lee, Taek Hwan; Kim, Sun Yeou; Kim, Seung Hyun.

In: Helvetica Chimica Acta, Vol. 99, No. 9, 01.01.2016, p. 681-686.

Research output: Contribution to journalArticle

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T1 - Megastigmane Glycosides from Docynia indica and Their Anti-inflammatory Activities

AU - Dung, Hoang Viet

AU - Bach, Nguyen Van

AU - Trung, Trinh Nam

AU - Nhiem, Nguyen Xuan

AU - Tai, Bui Huu

AU - Kiem, Phan Van

AU - Park, Seon Ju

AU - Lee, Taek Hwan

AU - Kim, Sun Yeou

AU - Kim, Seung Hyun

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Using various chromatographic methods, three new megastigmane glycosides, docynicasides A – C (1 – 3) and ten known, (6S,9R)-vomifoliol 9-O-β-d-xylopyranosyl-(1′′→6′)-O-β-d-glucopyranoside (4), hyperin (5), quercitrin (6), quercetin 3-α-l-arabinofuranoside (7), naringenin 7-O-β-d-glucopyranoside (8), phloridzin (9), phloretin 2′-O-β-d-xylopyranosyl-(1→6)-β-d-glucopyranoside (10), pinosylvin 3-O-β-d-glucopyranoside (11), tormentic acid (12), and chlorogenic acid methyl ester (13) were isolated from the fruits of Docynia indica. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for the inhibitory activity on NO production in LPS-stimulated BV2 cells. As the results, compounds 3 – 5 showed significant inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC 50 values ranging from 21.0 to 29.3 μm.

AB - Using various chromatographic methods, three new megastigmane glycosides, docynicasides A – C (1 – 3) and ten known, (6S,9R)-vomifoliol 9-O-β-d-xylopyranosyl-(1′′→6′)-O-β-d-glucopyranoside (4), hyperin (5), quercitrin (6), quercetin 3-α-l-arabinofuranoside (7), naringenin 7-O-β-d-glucopyranoside (8), phloridzin (9), phloretin 2′-O-β-d-xylopyranosyl-(1→6)-β-d-glucopyranoside (10), pinosylvin 3-O-β-d-glucopyranoside (11), tormentic acid (12), and chlorogenic acid methyl ester (13) were isolated from the fruits of Docynia indica. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for the inhibitory activity on NO production in LPS-stimulated BV2 cells. As the results, compounds 3 – 5 showed significant inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC 50 values ranging from 21.0 to 29.3 μm.

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