Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells

Ji Hye Jung, Hyun Jung Choi, Yong Sun Maeng, Jung Yeon Choi, Minhyung Kim, Ja Young Kwon, Yong Won Park, Young Myeong Kim, Daehee Hwang, Young-Guen Kwon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression.

Original languageEnglish
Pages (from-to)523-530
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume400
Issue number4
DOIs
Publication statusPublished - 2010 Oct 1

Fingerprint

Endothelial cells
Gene expression
Cell Differentiation
Claudin-5
Endothelial Cells
Genes
Angiopoietins
Angiopoietin-2
Gene Expression
Vascular Endothelial Growth Factor Receptor-2
Gene Expression Profiling
Microarray Analysis
Microarrays
Proteins
Endothelial Progenitor Cells
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Jung, Ji Hye ; Choi, Hyun Jung ; Maeng, Yong Sun ; Choi, Jung Yeon ; Kim, Minhyung ; Kwon, Ja Young ; Park, Yong Won ; Kim, Young Myeong ; Hwang, Daehee ; Kwon, Young-Guen. / Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells. In: Biochemical and Biophysical Research Communications. 2010 ; Vol. 400, No. 4. pp. 523-530.
@article{04a918b5a1ac4329aeecba7677da8391,
title = "Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells",
abstract = "Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression.",
author = "Jung, {Ji Hye} and Choi, {Hyun Jung} and Maeng, {Yong Sun} and Choi, {Jung Yeon} and Minhyung Kim and Kwon, {Ja Young} and Park, {Yong Won} and Kim, {Young Myeong} and Daehee Hwang and Young-Guen Kwon",
year = "2010",
month = "10",
day = "1",
doi = "10.1016/j.bbrc.2010.08.086",
language = "English",
volume = "400",
pages = "523--530",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "4",

}

Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells. / Jung, Ji Hye; Choi, Hyun Jung; Maeng, Yong Sun; Choi, Jung Yeon; Kim, Minhyung; Kwon, Ja Young; Park, Yong Won; Kim, Young Myeong; Hwang, Daehee; Kwon, Young-Guen.

In: Biochemical and Biophysical Research Communications, Vol. 400, No. 4, 01.10.2010, p. 523-530.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells

AU - Jung, Ji Hye

AU - Choi, Hyun Jung

AU - Maeng, Yong Sun

AU - Choi, Jung Yeon

AU - Kim, Minhyung

AU - Kwon, Ja Young

AU - Park, Yong Won

AU - Kim, Young Myeong

AU - Hwang, Daehee

AU - Kwon, Young-Guen

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression.

AB - Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression.

UR - http://www.scopus.com/inward/record.url?scp=77957277896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957277896&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2010.08.086

DO - 10.1016/j.bbrc.2010.08.086

M3 - Article

VL - 400

SP - 523

EP - 530

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 4

ER -