Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells

Ji Hye Jung, Hyun Jung Choi, Yong Sun Maeng, Jung Yeon Choi, Minhyung Kim, Ja Young Kwon, Yong Won Park, Young Myeong Kim, Daehee Hwang, Young Guen Kwon

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7 Citations (Scopus)

Abstract

Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression.

Original languageEnglish
Pages (from-to)523-530
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume400
Issue number4
DOIs
Publication statusPublished - 2010 Oct 1

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Jung, J. H., Choi, H. J., Maeng, Y. S., Choi, J. Y., Kim, M., Kwon, J. Y., Park, Y. W., Kim, Y. M., Hwang, D., & Kwon, Y. G. (2010). Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells. Biochemical and Biophysical Research Communications, 400(4), 523-530. https://doi.org/10.1016/j.bbrc.2010.08.086