Melanocytoma of the optic disk in the Korean population

Christopher S. Lee, Jeong H. Bae, Ik H. Jeon, Suk H. Byeon, Hyoung J. Koh, Sungchul Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: To report on the clinical features and the natural course of optic disk melanocytoma in the Korean population. Methods: A retrospective review of medical records was performed on 27 consecutive patients with optic disk melanocytoma. In cases with tumor enlargement, surface area and diameter of tumors were measured from fundus images using computer software. Results: The median age at diagnosis was 46 years with a slight female predominance (63%). The median tumor diameter and height were 3.1 mm and 1.9 mm, respectively. There were no cases with tumor-related visual loss for a median follow-up of 2 years. Tumor enlargement was observed in 4 of 21 patients (19%) that had follow-up of 1 year or more with no malignant transformation. The mean change of tumor surface area was 2.4 mm (52% increase), and the mean change of tumor diameter was 1.8 mm over a mean follow-up of 53 months in 4 cases with tumor growth. Only tumor vascularization on fluorescent angiography correlated with tumor growth (Log-rank test; P = 0.049). Kaplan-Meier survival estimated that the tumor growth was 0% at 1 year, 14% at 5 years, and 57% at 8 years. Conclusion: Optic disk melanocytoma in the Korean population tends to be superiorly located in the optic disk, and visual prognosis was excellent. Periodic ocular examination is warranted because 57% of patients were estimated to show tumor enlargement by 8 years of follow-up.

Original languageEnglish
Pages (from-to)1714-1720
Number of pages7
JournalRetina
Volume30
Issue number10
DOIs
Publication statusPublished - 2010 Nov 1

Fingerprint

Optic Disk
Population
Neoplasms
Growth
Medical Records
Angiography
Software

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Lee, C. S., Bae, J. H., Jeon, I. H., Byeon, S. H., Koh, H. J., & Lee, S. (2010). Melanocytoma of the optic disk in the Korean population. Retina, 30(10), 1714-1720. https://doi.org/10.1097/IAE.0b013e3181dd0bd3
Lee, Christopher S. ; Bae, Jeong H. ; Jeon, Ik H. ; Byeon, Suk H. ; Koh, Hyoung J. ; Lee, Sungchul. / Melanocytoma of the optic disk in the Korean population. In: Retina. 2010 ; Vol. 30, No. 10. pp. 1714-1720.
@article{378d8474505c4742b5ff65925c2d8c90,
title = "Melanocytoma of the optic disk in the Korean population",
abstract = "Purpose: To report on the clinical features and the natural course of optic disk melanocytoma in the Korean population. Methods: A retrospective review of medical records was performed on 27 consecutive patients with optic disk melanocytoma. In cases with tumor enlargement, surface area and diameter of tumors were measured from fundus images using computer software. Results: The median age at diagnosis was 46 years with a slight female predominance (63{\%}). The median tumor diameter and height were 3.1 mm and 1.9 mm, respectively. There were no cases with tumor-related visual loss for a median follow-up of 2 years. Tumor enlargement was observed in 4 of 21 patients (19{\%}) that had follow-up of 1 year or more with no malignant transformation. The mean change of tumor surface area was 2.4 mm (52{\%} increase), and the mean change of tumor diameter was 1.8 mm over a mean follow-up of 53 months in 4 cases with tumor growth. Only tumor vascularization on fluorescent angiography correlated with tumor growth (Log-rank test; P = 0.049). Kaplan-Meier survival estimated that the tumor growth was 0{\%} at 1 year, 14{\%} at 5 years, and 57{\%} at 8 years. Conclusion: Optic disk melanocytoma in the Korean population tends to be superiorly located in the optic disk, and visual prognosis was excellent. Periodic ocular examination is warranted because 57{\%} of patients were estimated to show tumor enlargement by 8 years of follow-up.",
author = "Lee, {Christopher S.} and Bae, {Jeong H.} and Jeon, {Ik H.} and Byeon, {Suk H.} and Koh, {Hyoung J.} and Sungchul Lee",
year = "2010",
month = "11",
day = "1",
doi = "10.1097/IAE.0b013e3181dd0bd3",
language = "English",
volume = "30",
pages = "1714--1720",
journal = "Retina",
issn = "0275-004X",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

Lee, CS, Bae, JH, Jeon, IH, Byeon, SH, Koh, HJ & Lee, S 2010, 'Melanocytoma of the optic disk in the Korean population', Retina, vol. 30, no. 10, pp. 1714-1720. https://doi.org/10.1097/IAE.0b013e3181dd0bd3

Melanocytoma of the optic disk in the Korean population. / Lee, Christopher S.; Bae, Jeong H.; Jeon, Ik H.; Byeon, Suk H.; Koh, Hyoung J.; Lee, Sungchul.

In: Retina, Vol. 30, No. 10, 01.11.2010, p. 1714-1720.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Melanocytoma of the optic disk in the Korean population

AU - Lee, Christopher S.

AU - Bae, Jeong H.

AU - Jeon, Ik H.

AU - Byeon, Suk H.

AU - Koh, Hyoung J.

AU - Lee, Sungchul

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Purpose: To report on the clinical features and the natural course of optic disk melanocytoma in the Korean population. Methods: A retrospective review of medical records was performed on 27 consecutive patients with optic disk melanocytoma. In cases with tumor enlargement, surface area and diameter of tumors were measured from fundus images using computer software. Results: The median age at diagnosis was 46 years with a slight female predominance (63%). The median tumor diameter and height were 3.1 mm and 1.9 mm, respectively. There were no cases with tumor-related visual loss for a median follow-up of 2 years. Tumor enlargement was observed in 4 of 21 patients (19%) that had follow-up of 1 year or more with no malignant transformation. The mean change of tumor surface area was 2.4 mm (52% increase), and the mean change of tumor diameter was 1.8 mm over a mean follow-up of 53 months in 4 cases with tumor growth. Only tumor vascularization on fluorescent angiography correlated with tumor growth (Log-rank test; P = 0.049). Kaplan-Meier survival estimated that the tumor growth was 0% at 1 year, 14% at 5 years, and 57% at 8 years. Conclusion: Optic disk melanocytoma in the Korean population tends to be superiorly located in the optic disk, and visual prognosis was excellent. Periodic ocular examination is warranted because 57% of patients were estimated to show tumor enlargement by 8 years of follow-up.

AB - Purpose: To report on the clinical features and the natural course of optic disk melanocytoma in the Korean population. Methods: A retrospective review of medical records was performed on 27 consecutive patients with optic disk melanocytoma. In cases with tumor enlargement, surface area and diameter of tumors were measured from fundus images using computer software. Results: The median age at diagnosis was 46 years with a slight female predominance (63%). The median tumor diameter and height were 3.1 mm and 1.9 mm, respectively. There were no cases with tumor-related visual loss for a median follow-up of 2 years. Tumor enlargement was observed in 4 of 21 patients (19%) that had follow-up of 1 year or more with no malignant transformation. The mean change of tumor surface area was 2.4 mm (52% increase), and the mean change of tumor diameter was 1.8 mm over a mean follow-up of 53 months in 4 cases with tumor growth. Only tumor vascularization on fluorescent angiography correlated with tumor growth (Log-rank test; P = 0.049). Kaplan-Meier survival estimated that the tumor growth was 0% at 1 year, 14% at 5 years, and 57% at 8 years. Conclusion: Optic disk melanocytoma in the Korean population tends to be superiorly located in the optic disk, and visual prognosis was excellent. Periodic ocular examination is warranted because 57% of patients were estimated to show tumor enlargement by 8 years of follow-up.

UR - http://www.scopus.com/inward/record.url?scp=78650178351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650178351&partnerID=8YFLogxK

U2 - 10.1097/IAE.0b013e3181dd0bd3

DO - 10.1097/IAE.0b013e3181dd0bd3

M3 - Article

VL - 30

SP - 1714

EP - 1720

JO - Retina

JF - Retina

SN - 0275-004X

IS - 10

ER -

Lee CS, Bae JH, Jeon IH, Byeon SH, Koh HJ, Lee S. Melanocytoma of the optic disk in the Korean population. Retina. 2010 Nov 1;30(10):1714-1720. https://doi.org/10.1097/IAE.0b013e3181dd0bd3