Melanosis coli: Histochemical and immunohistochemical comparison of the pigments of melanosis coli and Dubin-Johnson syndrome

C. Park, N. H. Cho, H. J. Jeong

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We compared the pigment of melanosis coli with the pigment of Dubin-Johnson syndrome, melanin, and lipofuscin. The pigment of melanosis coli appeared similar to lipofuscin in that it stained positively with periodic acid-Schiff, oil red-O and Victoria blue stains and revealed negative reactions to the immunohistochemical stains for S-100 protein and neuron specific enolase, but has similarity to melanin as shown by the positive reaction to Fontana-Masson stain and negative autofluorescence. The pigment of Dubin-Johnson syndrome showed the same histochemical and immunohistochemical characteristics as that of melanosis coli. The results indicate that the pigments of melanosis coli and Dubin-Johnson syndrome are identical and are variants of lipofuscin.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalYonsei medical journal
Issue number1
Publication statusPublished - 1990 Jan 1


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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