MELDB: A database for microbial esterases and lipases

Ho Young Kang, Jihyun F. Kim, Myung Hee Kim, Seung Hwan Park, Tae Kwang Oh, Cheol Goo Hur

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

MELDB is a comprehensive protein database of microbial esterases and lipases which are hydrolytic enzymes important in the modern industry. Proteins in MELDB are clustered into groups according to their sequence similarities based on a local pairwise alignment algorithm and a graph clustering algorithm (TribeMCL). This differs from traditional approaches that use global pairwise alignment and joining methods. Our procedure was able to reduce the noise caused by dubious alignment in the distantly related or unrelated regions in the sequences. In the database, 883 esterase and lipase sequences derived from microbial sources are deposited and conserved parts of each protein are identified. HMM profiles of each cluster were generated to classify unknown sequences. Contents of the database can be keyword-searched and query sequences can be aligned to sequence profiles and sequences themselves.

Original languageEnglish
Pages (from-to)2736-2740
Number of pages5
JournalFEBS Letters
Volume580
Issue number11
DOIs
Publication statusPublished - 2006 May 15

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Kang, H. Y., Kim, J. F., Kim, M. H., Park, S. H., Oh, T. K., & Hur, C. G. (2006). MELDB: A database for microbial esterases and lipases. FEBS Letters, 580(11), 2736-2740. https://doi.org/10.1016/j.febslet.2006.04.034