Membrane disruption by optically controlled microbubble cavitation

Paul Prentice, Alfred Cuschieri, Kishan Dholakia, Mark Prausnitz, Paul Campbell

Research output: Contribution to journalArticle

402 Citations (Scopus)

Abstract

In fluids, pressure-driven cavitation bubbles have a nonlinear response that can lead to extremely high core-energy densities during the collapse phase - a process underpinning phenomena such as sonoluminescence 1 and plasma formation 2 . If cavitation occurs near a rigid surface, the bubbles tend to collapse asymmetrically, often forming fast-moving liquid jets that may create localized surface damage 3 . As encapsulated microbubbles are commonly used to improve echo generation in diagnostic ultrasound imaging, it is possible that such cavitation could also lead to jet-induced tissue damage. Certainly ultrasonic irradiation (insonation) of cells in the presence of microbubbles can lead to enhanced membrane permeabilization and molecular uptake (sonoporation) 4-7 , but, although the mechanism during low-intensity insonation is clear 8 , experimental corroboration for higher pressure regimes has remained elusive. Here we show direct observational evidence that illuminates the energetic micrometre-scale interactions between individual cells and violently cavitating shelled microbubbles. Our data suggest that sonoporation at higher intensities may arise through a synergistic interplay involving several distinct processes.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalNature Physics
Volume1
Issue number2
DOIs
Publication statusPublished - 2005 Nov 1

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cavitation flow
membranes
bubbles
damage
sonoluminescence
fluid pressure
cells
micrometers
echoes
flux density
ultrasonics
irradiation
liquids
interactions

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

Prentice, P., Cuschieri, A., Dholakia, K., Prausnitz, M., & Campbell, P. (2005). Membrane disruption by optically controlled microbubble cavitation. Nature Physics, 1(2), 107-110. https://doi.org/10.1038/nphys148
Prentice, Paul ; Cuschieri, Alfred ; Dholakia, Kishan ; Prausnitz, Mark ; Campbell, Paul. / Membrane disruption by optically controlled microbubble cavitation. In: Nature Physics. 2005 ; Vol. 1, No. 2. pp. 107-110.
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Prentice, P, Cuschieri, A, Dholakia, K, Prausnitz, M & Campbell, P 2005, 'Membrane disruption by optically controlled microbubble cavitation', Nature Physics, vol. 1, no. 2, pp. 107-110. https://doi.org/10.1038/nphys148

Membrane disruption by optically controlled microbubble cavitation. / Prentice, Paul; Cuschieri, Alfred; Dholakia, Kishan; Prausnitz, Mark; Campbell, Paul.

In: Nature Physics, Vol. 1, No. 2, 01.11.2005, p. 107-110.

Research output: Contribution to journalArticle

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