Menstrual state should be considered in determining sero-positivity of soluble angiogenic factors in breast cancer.

Hyuncheol Chung, SunYoung Rha, J. B. Ahn, K. Y. Shim, N. C. Yoo, J. H. Kim, J. K. Roh, K. S. Lee, J. S. Min, B. S. Kim, J. J. Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We investigated whether blood angiogenic factor (vascular endothelial growth factor, VEGF; angiogenin; basic fibroblast growth factor, bFGF; platelet-derived growth factor-AB, PDGF-AB) levels change during menstrual cycle of healthy premenopausal females or after menopause. We also measured the serum angiogenic factor levels in 34 operable breast cancer patients and compared them to those of healthy volunteer controls. No differences in the four angiogenic factor levels were found between the follicular and luteal phases of normal menstruation. However, angiogenin and bFGF levels were higher in pre-menopausal females than post-menopausal female and young male healthy volunteers. In cancer patients, the sero-positivity rate of the bFGF was 8.8% with menstrual-state-unmatched cut-off points, which increased to 36.4% with menstrual-state-matched cut-off points. This discrepancy was especially high in post-menopausal cancer patients. In conclusion, physiological elevation of the bFGF during normal menstruation can influence the precise interpretation of the pathological elevation of the bFGF in pre-menopausal breast cancer patients.

Original languageEnglish
Pages (from-to)465-470
Number of pages6
JournalInternational journal of molecular medicine
Volume2
Issue number4
Publication statusPublished - 1998 Jan 1

Fingerprint

Angiogenesis Inducing Agents
Breast Neoplasms
Menstruation
Vascular Endothelial Growth Factor A
Healthy Volunteers
Follicular Phase
Luteal Phase
Fibroblast Growth Factor 2
Menstrual Cycle
Menopause
Neoplasms
Serum
angiogenin
platelet-derived growth factor AB

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Chung, Hyuncheol ; Rha, SunYoung ; Ahn, J. B. ; Shim, K. Y. ; Yoo, N. C. ; Kim, J. H. ; Roh, J. K. ; Lee, K. S. ; Min, J. S. ; Kim, B. S. ; Kim, J. J. / Menstrual state should be considered in determining sero-positivity of soluble angiogenic factors in breast cancer. In: International journal of molecular medicine. 1998 ; Vol. 2, No. 4. pp. 465-470.
@article{64076d1dce964940bf2b354c9b1589ab,
title = "Menstrual state should be considered in determining sero-positivity of soluble angiogenic factors in breast cancer.",
abstract = "We investigated whether blood angiogenic factor (vascular endothelial growth factor, VEGF; angiogenin; basic fibroblast growth factor, bFGF; platelet-derived growth factor-AB, PDGF-AB) levels change during menstrual cycle of healthy premenopausal females or after menopause. We also measured the serum angiogenic factor levels in 34 operable breast cancer patients and compared them to those of healthy volunteer controls. No differences in the four angiogenic factor levels were found between the follicular and luteal phases of normal menstruation. However, angiogenin and bFGF levels were higher in pre-menopausal females than post-menopausal female and young male healthy volunteers. In cancer patients, the sero-positivity rate of the bFGF was 8.8{\%} with menstrual-state-unmatched cut-off points, which increased to 36.4{\%} with menstrual-state-matched cut-off points. This discrepancy was especially high in post-menopausal cancer patients. In conclusion, physiological elevation of the bFGF during normal menstruation can influence the precise interpretation of the pathological elevation of the bFGF in pre-menopausal breast cancer patients.",
author = "Hyuncheol Chung and SunYoung Rha and Ahn, {J. B.} and Shim, {K. Y.} and Yoo, {N. C.} and Kim, {J. H.} and Roh, {J. K.} and Lee, {K. S.} and Min, {J. S.} and Kim, {B. S.} and Kim, {J. J.}",
year = "1998",
month = "1",
day = "1",
language = "English",
volume = "2",
pages = "465--470",
journal = "International Journal of Molecular Medicine",
issn = "1107-3756",
publisher = "Spandidos Publications",
number = "4",

}

Chung, H, Rha, S, Ahn, JB, Shim, KY, Yoo, NC, Kim, JH, Roh, JK, Lee, KS, Min, JS, Kim, BS & Kim, JJ 1998, 'Menstrual state should be considered in determining sero-positivity of soluble angiogenic factors in breast cancer.', International journal of molecular medicine, vol. 2, no. 4, pp. 465-470.

Menstrual state should be considered in determining sero-positivity of soluble angiogenic factors in breast cancer. / Chung, Hyuncheol; Rha, SunYoung; Ahn, J. B.; Shim, K. Y.; Yoo, N. C.; Kim, J. H.; Roh, J. K.; Lee, K. S.; Min, J. S.; Kim, B. S.; Kim, J. J.

In: International journal of molecular medicine, Vol. 2, No. 4, 01.01.1998, p. 465-470.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Menstrual state should be considered in determining sero-positivity of soluble angiogenic factors in breast cancer.

AU - Chung, Hyuncheol

AU - Rha, SunYoung

AU - Ahn, J. B.

AU - Shim, K. Y.

AU - Yoo, N. C.

AU - Kim, J. H.

AU - Roh, J. K.

AU - Lee, K. S.

AU - Min, J. S.

AU - Kim, B. S.

AU - Kim, J. J.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - We investigated whether blood angiogenic factor (vascular endothelial growth factor, VEGF; angiogenin; basic fibroblast growth factor, bFGF; platelet-derived growth factor-AB, PDGF-AB) levels change during menstrual cycle of healthy premenopausal females or after menopause. We also measured the serum angiogenic factor levels in 34 operable breast cancer patients and compared them to those of healthy volunteer controls. No differences in the four angiogenic factor levels were found between the follicular and luteal phases of normal menstruation. However, angiogenin and bFGF levels were higher in pre-menopausal females than post-menopausal female and young male healthy volunteers. In cancer patients, the sero-positivity rate of the bFGF was 8.8% with menstrual-state-unmatched cut-off points, which increased to 36.4% with menstrual-state-matched cut-off points. This discrepancy was especially high in post-menopausal cancer patients. In conclusion, physiological elevation of the bFGF during normal menstruation can influence the precise interpretation of the pathological elevation of the bFGF in pre-menopausal breast cancer patients.

AB - We investigated whether blood angiogenic factor (vascular endothelial growth factor, VEGF; angiogenin; basic fibroblast growth factor, bFGF; platelet-derived growth factor-AB, PDGF-AB) levels change during menstrual cycle of healthy premenopausal females or after menopause. We also measured the serum angiogenic factor levels in 34 operable breast cancer patients and compared them to those of healthy volunteer controls. No differences in the four angiogenic factor levels were found between the follicular and luteal phases of normal menstruation. However, angiogenin and bFGF levels were higher in pre-menopausal females than post-menopausal female and young male healthy volunteers. In cancer patients, the sero-positivity rate of the bFGF was 8.8% with menstrual-state-unmatched cut-off points, which increased to 36.4% with menstrual-state-matched cut-off points. This discrepancy was especially high in post-menopausal cancer patients. In conclusion, physiological elevation of the bFGF during normal menstruation can influence the precise interpretation of the pathological elevation of the bFGF in pre-menopausal breast cancer patients.

UR - http://www.scopus.com/inward/record.url?scp=0009636367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0009636367&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 465

EP - 470

JO - International Journal of Molecular Medicine

JF - International Journal of Molecular Medicine

SN - 1107-3756

IS - 4

ER -