Mesenchymal stem cell-mediated effects of tumor support or suppression

Ki Jong Rhee, Jong In Lee, Young Woo Eom

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) can exhibit a marked tropism towards site of tumors. Many studies have reported that tumor progression and metastasis increase by MSCs. In contrast, other studies have shown that MSCs suppress growth of tumors. MSCs contribute to tumor growth promotion by several mechanisms: (1) transition to tumor-associated fibroblasts; (2) suppression of immune response; (3) promotion of angiogenesis; (4) stimulation of epithelial-mesenchymal transition (EMT); (5) contribution to the tumor microenvironment; (6) inhibition of tumor cell apoptosis; and (7) promotion of tumor metastasis. In contrast to the tumor-promoting properties, MSCs inhibit tumor growth by increasing inflammatory infiltration, inhibiting angiogenesis, suppressing Wnt signaling and AKT signaling, and inducing cell cycle arrest and apoptosis. In this review, we will discuss potential mechanisms by which MSC mediates tumor support or suppression and then the possible tumor-specific therapeutic strategies using MSCs as delivery vehicles, based on their homing potential to tumors.

Original languageEnglish
Pages (from-to)30015-30033
Number of pages19
JournalInternational journal of molecular sciences
Volume16
Issue number12
DOIs
Publication statusPublished - 2015 Dec 16

Fingerprint

stem cells
Stem cells
Mesenchymal Stromal Cells
Tumors
tumors
retarding
Neoplasms
promotion
angiogenesis
apoptosis
metastasis
Cell death
Growth
tropism
Apoptosis
Neoplasm Metastasis
Cells
homing
Tropism
Epithelial-Mesenchymal Transition

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Rhee, Ki Jong ; Lee, Jong In ; Eom, Young Woo. / Mesenchymal stem cell-mediated effects of tumor support or suppression. In: International journal of molecular sciences. 2015 ; Vol. 16, No. 12. pp. 30015-30033.
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Mesenchymal stem cell-mediated effects of tumor support or suppression. / Rhee, Ki Jong; Lee, Jong In; Eom, Young Woo.

In: International journal of molecular sciences, Vol. 16, No. 12, 16.12.2015, p. 30015-30033.

Research output: Contribution to journalArticle

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