Mesenchymal stem cells for the treatment of liver disease: Present and perspectives

Seong Hee Kang, Moon Young Kim, Young Woo Eom, Soon Koo Baik

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Mesenchymal stem cell transplantation is an emerging therapy for treating chronic liver diseases. The potential of this treatment has been evaluated in preclinical and clinical studies. Although the mechanisms of mesenchymal stem cell transplantation are still not completely understood, accumulating evidence has revealed that their immunomodulation, differentiation, and antifibrotic properties play a crucial role in liver regeneration. The safety and therapeutic effects of mesenchymal stem cells in patients with chronic liver disease have been observed in many clinical studies. However, only modest improvements have been seen, partly because of the limited feasibility of transplanted cells at present. Here, we discuss several strategies targeted at improving viable cell engraftment and the potential challenges in the use of extracellular vesicle-based therapies for liver disease in the future.

Original languageEnglish
Pages (from-to)306-315
Number of pages10
JournalGut and liver
Volume14
Issue number3
DOIs
Publication statusPublished - 2020

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (2017R1A5A2015369, 2017R1A2B4009199, 2017R1D1A1A0 2019212, and 2018R1C1B5044890) and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI15C2364 and HI17C1365).

Publisher Copyright:
© 2020 Editorial Office of Gut and Liver. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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