Background/Aim: Uterine mesonephric-like adenocarcinoma (MLA) is a rare malignant tumor of the female genital tract. Patients and Methods: We reviewed 237 endometrial carcinoma cases and investigated the clinicopathological and molecular characteristics of uterine MLA. Results: We found that 3.0% (7/237) of the endometrial carcinoma cases were MLAs. Compared to endometrial endometrioid carcinoma, MLA showed larger tumor size, deeper myometrial invasion, increasingly advanced-stage disease, and more frequent lymphovascular space invasion. All MLAs exhibited architectural diversity, compactly aggregated small tubules, eosinophilic intraluminal secretions, overlapped and angulated nuclei, scant cytoplasm, and presence of spindle cells. All the MLAs expressed at least two mesonephric markers. All except one MLA harbored activating Kirsten rat sarcoma viral oncogene homolog mutations. All patients with MLA developed postoperative metastases. MLA had the lowest progression-free survival rate among different histological types of endometrial carcinoma. Conclusion: Uterine MLA is a highly aggressive gynecological malignancy, showing unique morphological and molecular features, frequent recurrences and metastases, as well as poor prognosis.
|Number of pages||14|
|Journal||Cancer Genomics and Proteomics|
|Publication status||Published - 2022 Jul|
Bibliographical noteFunding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (2020R1G1A1003692), the Bio and Medical Technology Development Program of the NRF funded by the Korean government (MSIT) (2019M3E5D1A02068558), and a grant of the Korea health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by Ministry of Health & Welfare, Republic of Korea (HR20C0025).
© 2022 International Institute of Anticancer Research. All rights reserved.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cancer Research