Meta-classifiers for high-dimensional, small sample classification for gene expression analysis

Kyung Joong Kim, Sung Bae Cho

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Classification using small sample size (limited number of samples) with high dimension is a challenging problem in both machine learning and medicine as there are a wide variety of possible modeling approaches. Furthermore, it is not always clear which method is optimal for a prediction task. Different modeling choices include feature selection (dimensionality reduction), classification algorithms, and ensemble selection. There are several possible combinations of these methods, and it is not always clear which is the best. In the previous works, researchers show that evolutionary computation is useful to build an ensemble from the pairs of feature selection and classification algorithms. However, there are several parameters to be determined for the evolutionary computation and it requires computational time for the optimization. In this paper, we attempt to improve the approach by adopting meta-classification with the farthest-first clustering algorithm. The effectiveness and accuracy of our method are validated by experiments on four real microarray datasets (colon, breast, prostate and lymphoma cancers) publicly available. The results confirm that the proposed method outperforms single individual classifiers and other alternatives (standard genetic algorithm, and methods from literature).

Original languageEnglish
Pages (from-to)553-569
Number of pages17
JournalPattern Analysis and Applications
Issue number3
Publication statusPublished - 2015 Aug 24

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (2013 R1A2A2A01016589, 2010-0018950, 2010-0018948).

Publisher Copyright:
© 2014, Springer-Verlag London.

All Science Journal Classification (ASJC) codes

  • Computer Vision and Pattern Recognition
  • Artificial Intelligence


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