Metabolic phenotyping of human atherosclerotic plaques: Metabolic alterations and their biological relevance in plaque-containing aorta

Sunhee Jung, Suk Won Song, Sak Lee, Se Hoon Kim, Soo jin Ann, Eun Jeong Cheon, Gijong Yi, Eui Young Choi, Seung Hyun Lee, Hyun Chel Joo, Do Hyun Ryu, Sang Hak Lee, Geum Sook Hwang

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Abstract

Background and aims Atherosclerosis is a chronic inflammatory disease characterized by thickening of the arterial wall. However, a limited number of studies have been conducted on metabolic profiling of human aortic tissue. Methods We applied liquid chromatography/mass spectrometry to perform global and targeted profiling of plaque-containing aortic tissue. The aorta samples included plaque-containing (n = 18) and control plaque-free (n = 24) aortic tissue from patients undergoing aortic surgery. Results The metabolic patterns of atherosclerotic and control vessels were significantly different. Metabolites in the purine and glutathione pathways showed dysregulation of oxidative stress in plaques, and levels of glucosylceramide, tryptophan, and kynurenine, which are related to inflammation, were also altered. Interestingly, an increased level of quinic acid was observed in plaques (p < 0.000), and we demonstrated an inhibitory effect of quinic acid on inflammatory activation and oxidative stress in macrophages. Conclusions Our study provides insight into the disease mechanism and potential markers of atherosclerosis through comprehensive metabolic profiling of human aortic tissue samples containing plaque.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalAtherosclerosis
Volume269
DOIs
Publication statusPublished - 2018 Feb

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Jung, S., Song, S. W., Lee, S., Kim, S. H., Ann, S. J., Cheon, E. J., Yi, G., Choi, E. Y., Lee, S. H., Joo, H. C., Ryu, D. H., Lee, S. H., & Hwang, G. S. (2018). Metabolic phenotyping of human atherosclerotic plaques: Metabolic alterations and their biological relevance in plaque-containing aorta. Atherosclerosis, 269, 21-28. https://doi.org/10.1016/j.atherosclerosis.2017.11.034