Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults

Jin Kim Hae, Jin Kim Hyeong, Eun Lee Kwang, Jung Kim Dae, Kyung Kim Soo, Woo Ahn Chul, Sungkil Lim, Rae Kim Kyung, Chul Lee Hyun, Bum Huh Kap, Soo Cha Bong

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Abstract

Background: Obesity and type 2 diabetes are well-known risk factors for the development of nonalcoholic fatty liver disease (NAFLD). However, NAFLD is not rare in nonobese, nondiabetic adults. The aim of this study was to evaluate the metabolic significance of NAFLD in nonobese, nondiabetic adults. Methods: This study examined 768 nonobese (body mass index [BMI] [calculated as weight in kilograms divided by the square of height in meters], ≥18.5 and <30) (460 normal-weight and 308 overweight subjects), nondiabetic individuals older than 30 years who participated in a medical checkup. All the subjects had negative serologic findings for hepatitis B and C viruses and had an alcohol intake less than 140 g/wk. A standard interview, anthropometries, a biochemical study, and abdominal ultrasonography were conducted. Rosults: The prevalence of NAFLD in the enrolled subjects was 23,4%. In the normal-weight (BMI, ≥18.5 and <25) and overweight (BMI, ≥25 and <30) groups, NAFLD was a significant predictor of insulin resistance and other metabolic disorders, including hypertriglyceridemia and hyperuricemia. The odds ratio of the metabolic disorders in subjects with NAFLD compared with those without NAFLD in the normal-weight group was higher than that in the overweight group. Multiple logistic regression analysis showed that sex, waist circumference, triglyceride level, and insulin resistance were independently associated with NAFLD in the normalweight group. Conclusions: Nonalcoholic fatty liver disease is closely associated with metabolic disorders, even in nonobese, nondiabetic subjects. Nonalcoholic fatty liver disease can be considered an early predictor of metabolic disorders, particularly in the normal-weight population.

Original languageEnglish
Pages (from-to)2169-2175
Number of pages7
JournalArchives of Internal Medicine
Volume164
Issue number19
DOIs
Publication statusPublished - 2004 Oct 25

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Weights and Measures
Body Mass Index
Insulin Resistance
Non-alcoholic Fatty Liver Disease
Hyperuricemia
Anthropometry
Hypertriglyceridemia
Waist Circumference
Hepatitis B virus
Hepacivirus
Type 2 Diabetes Mellitus
Ultrasonography
Triglycerides
Obesity
Logistic Models
Odds Ratio
Regression Analysis
Alcohols
Interviews
Population

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Hae, J. K., Hyeong, J. K., Kwang, E. L., Dae, J. K., Soo, K. K., Chul, W. A., ... Bong, S. C. (2004). Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults. Archives of Internal Medicine, 164(19), 2169-2175. https://doi.org/10.1001/archinte.164.19.2169
Hae, Jin Kim ; Hyeong, Jin Kim ; Kwang, Eun Lee ; Dae, Jung Kim ; Soo, Kyung Kim ; Chul, Woo Ahn ; Lim, Sungkil ; Kyung, Rae Kim ; Hyun, Chul Lee ; Kap, Bum Huh ; Bong, Soo Cha. / Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults. In: Archives of Internal Medicine. 2004 ; Vol. 164, No. 19. pp. 2169-2175.
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abstract = "Background: Obesity and type 2 diabetes are well-known risk factors for the development of nonalcoholic fatty liver disease (NAFLD). However, NAFLD is not rare in nonobese, nondiabetic adults. The aim of this study was to evaluate the metabolic significance of NAFLD in nonobese, nondiabetic adults. Methods: This study examined 768 nonobese (body mass index [BMI] [calculated as weight in kilograms divided by the square of height in meters], ≥18.5 and <30) (460 normal-weight and 308 overweight subjects), nondiabetic individuals older than 30 years who participated in a medical checkup. All the subjects had negative serologic findings for hepatitis B and C viruses and had an alcohol intake less than 140 g/wk. A standard interview, anthropometries, a biochemical study, and abdominal ultrasonography were conducted. Rosults: The prevalence of NAFLD in the enrolled subjects was 23,4{\%}. In the normal-weight (BMI, ≥18.5 and <25) and overweight (BMI, ≥25 and <30) groups, NAFLD was a significant predictor of insulin resistance and other metabolic disorders, including hypertriglyceridemia and hyperuricemia. The odds ratio of the metabolic disorders in subjects with NAFLD compared with those without NAFLD in the normal-weight group was higher than that in the overweight group. Multiple logistic regression analysis showed that sex, waist circumference, triglyceride level, and insulin resistance were independently associated with NAFLD in the normalweight group. Conclusions: Nonalcoholic fatty liver disease is closely associated with metabolic disorders, even in nonobese, nondiabetic subjects. Nonalcoholic fatty liver disease can be considered an early predictor of metabolic disorders, particularly in the normal-weight population.",
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Hae, JK, Hyeong, JK, Kwang, EL, Dae, JK, Soo, KK, Chul, WA, Lim, S, Kyung, RK, Hyun, CL, Kap, BH & Bong, SC 2004, 'Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults', Archives of Internal Medicine, vol. 164, no. 19, pp. 2169-2175. https://doi.org/10.1001/archinte.164.19.2169

Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults. / Hae, Jin Kim; Hyeong, Jin Kim; Kwang, Eun Lee; Dae, Jung Kim; Soo, Kyung Kim; Chul, Woo Ahn; Lim, Sungkil; Kyung, Rae Kim; Hyun, Chul Lee; Kap, Bum Huh; Bong, Soo Cha.

In: Archives of Internal Medicine, Vol. 164, No. 19, 25.10.2004, p. 2169-2175.

Research output: Contribution to journalArticle

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T1 - Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults

AU - Hae, Jin Kim

AU - Hyeong, Jin Kim

AU - Kwang, Eun Lee

AU - Dae, Jung Kim

AU - Soo, Kyung Kim

AU - Chul, Woo Ahn

AU - Lim, Sungkil

AU - Kyung, Rae Kim

AU - Hyun, Chul Lee

AU - Kap, Bum Huh

AU - Bong, Soo Cha

PY - 2004/10/25

Y1 - 2004/10/25

N2 - Background: Obesity and type 2 diabetes are well-known risk factors for the development of nonalcoholic fatty liver disease (NAFLD). However, NAFLD is not rare in nonobese, nondiabetic adults. The aim of this study was to evaluate the metabolic significance of NAFLD in nonobese, nondiabetic adults. Methods: This study examined 768 nonobese (body mass index [BMI] [calculated as weight in kilograms divided by the square of height in meters], ≥18.5 and <30) (460 normal-weight and 308 overweight subjects), nondiabetic individuals older than 30 years who participated in a medical checkup. All the subjects had negative serologic findings for hepatitis B and C viruses and had an alcohol intake less than 140 g/wk. A standard interview, anthropometries, a biochemical study, and abdominal ultrasonography were conducted. Rosults: The prevalence of NAFLD in the enrolled subjects was 23,4%. In the normal-weight (BMI, ≥18.5 and <25) and overweight (BMI, ≥25 and <30) groups, NAFLD was a significant predictor of insulin resistance and other metabolic disorders, including hypertriglyceridemia and hyperuricemia. The odds ratio of the metabolic disorders in subjects with NAFLD compared with those without NAFLD in the normal-weight group was higher than that in the overweight group. Multiple logistic regression analysis showed that sex, waist circumference, triglyceride level, and insulin resistance were independently associated with NAFLD in the normalweight group. Conclusions: Nonalcoholic fatty liver disease is closely associated with metabolic disorders, even in nonobese, nondiabetic subjects. Nonalcoholic fatty liver disease can be considered an early predictor of metabolic disorders, particularly in the normal-weight population.

AB - Background: Obesity and type 2 diabetes are well-known risk factors for the development of nonalcoholic fatty liver disease (NAFLD). However, NAFLD is not rare in nonobese, nondiabetic adults. The aim of this study was to evaluate the metabolic significance of NAFLD in nonobese, nondiabetic adults. Methods: This study examined 768 nonobese (body mass index [BMI] [calculated as weight in kilograms divided by the square of height in meters], ≥18.5 and <30) (460 normal-weight and 308 overweight subjects), nondiabetic individuals older than 30 years who participated in a medical checkup. All the subjects had negative serologic findings for hepatitis B and C viruses and had an alcohol intake less than 140 g/wk. A standard interview, anthropometries, a biochemical study, and abdominal ultrasonography were conducted. Rosults: The prevalence of NAFLD in the enrolled subjects was 23,4%. In the normal-weight (BMI, ≥18.5 and <25) and overweight (BMI, ≥25 and <30) groups, NAFLD was a significant predictor of insulin resistance and other metabolic disorders, including hypertriglyceridemia and hyperuricemia. The odds ratio of the metabolic disorders in subjects with NAFLD compared with those without NAFLD in the normal-weight group was higher than that in the overweight group. Multiple logistic regression analysis showed that sex, waist circumference, triglyceride level, and insulin resistance were independently associated with NAFLD in the normalweight group. Conclusions: Nonalcoholic fatty liver disease is closely associated with metabolic disorders, even in nonobese, nondiabetic subjects. Nonalcoholic fatty liver disease can be considered an early predictor of metabolic disorders, particularly in the normal-weight population.

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