Metabolic syndrome and its association with white blood cell count in children and adolescents in Korea

The 2005 Korean National Health and Nutrition Examination Survey

Yongjae Lee, Y. H. Shin, J. K. Kim, J. Y. Shim, D. R. Kang, H. R. Lee

Research output: Contribution to journalArticle

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Abstract

Background and aims: To estimate the prevalence of metabolic syndrome (MS) and determine its association with white blood cell (WBC) count as a marker of low-grade systemic inflammation in children and adolescents in Korea. Methods and results: We investigated the prevalence of MS and its association with WBC count in 928 children and adolescents. MS was defined as having 3 or more conditions based on the modified criteria of the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III). The odds ratios (ORs) for MS were also calculated using multivariate logistic regression analysis across WBC count quartiles (Q1, <5200; Q2, 5200-6100; Q3, 6200-7200; and Q4, ≥7300 cells/μL for boys; Q1, <5200; Q2, 5200-6000; Q3, 6100-7000; and Q4, ≥7100 cells/μL for girls). The prevalence of MS in children and adolescents in Korea was 6.7% (8.5% in boys, 4.5% in girls, P < 0.001). MS was more prevalent in overweight and obese children and adolescents in both boys and girls. The mean WBC counts continuously increased with each additional component of MS in both boys and girls. The ORs (95% CIs) for MS in each WBC quartile were 1.00, 1.56 (0.43-5.67), 4.47 (1.42-14.07), and 5.25 (1.71-16.07) in boys and 1.00, 1.05 (0.15-7.61), 2.89 (0.55-15.17), and 7.47 (1.61-36.67) in girls after adjusting for age, household income, and residential area. Conclusion: In summary, this study shows that a substantial number of children and adolescents in Korea have MS, and elevated WBC count may be a surrogate marker for MS.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume20
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

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Nutrition Surveys
Korea
Leukocyte Count
Odds Ratio
Leukocytes
Biomarkers
Logistic Models
Cholesterol
Regression Analysis
Inflammation
Education

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

@article{b0a1a1f5734a457395d9e4db4e2ebd99,
title = "Metabolic syndrome and its association with white blood cell count in children and adolescents in Korea: The 2005 Korean National Health and Nutrition Examination Survey",
abstract = "Background and aims: To estimate the prevalence of metabolic syndrome (MS) and determine its association with white blood cell (WBC) count as a marker of low-grade systemic inflammation in children and adolescents in Korea. Methods and results: We investigated the prevalence of MS and its association with WBC count in 928 children and adolescents. MS was defined as having 3 or more conditions based on the modified criteria of the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III). The odds ratios (ORs) for MS were also calculated using multivariate logistic regression analysis across WBC count quartiles (Q1, <5200; Q2, 5200-6100; Q3, 6200-7200; and Q4, ≥7300 cells/μL for boys; Q1, <5200; Q2, 5200-6000; Q3, 6100-7000; and Q4, ≥7100 cells/μL for girls). The prevalence of MS in children and adolescents in Korea was 6.7{\%} (8.5{\%} in boys, 4.5{\%} in girls, P < 0.001). MS was more prevalent in overweight and obese children and adolescents in both boys and girls. The mean WBC counts continuously increased with each additional component of MS in both boys and girls. The ORs (95{\%} CIs) for MS in each WBC quartile were 1.00, 1.56 (0.43-5.67), 4.47 (1.42-14.07), and 5.25 (1.71-16.07) in boys and 1.00, 1.05 (0.15-7.61), 2.89 (0.55-15.17), and 7.47 (1.61-36.67) in girls after adjusting for age, household income, and residential area. Conclusion: In summary, this study shows that a substantial number of children and adolescents in Korea have MS, and elevated WBC count may be a surrogate marker for MS.",
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Metabolic syndrome and its association with white blood cell count in children and adolescents in Korea : The 2005 Korean National Health and Nutrition Examination Survey. / Lee, Yongjae; Shin, Y. H.; Kim, J. K.; Shim, J. Y.; Kang, D. R.; Lee, H. R.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 20, No. 3, 01.03.2010, p. 165-172.

Research output: Contribution to journalArticle

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T1 - Metabolic syndrome and its association with white blood cell count in children and adolescents in Korea

T2 - The 2005 Korean National Health and Nutrition Examination Survey

AU - Lee, Yongjae

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N2 - Background and aims: To estimate the prevalence of metabolic syndrome (MS) and determine its association with white blood cell (WBC) count as a marker of low-grade systemic inflammation in children and adolescents in Korea. Methods and results: We investigated the prevalence of MS and its association with WBC count in 928 children and adolescents. MS was defined as having 3 or more conditions based on the modified criteria of the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III). The odds ratios (ORs) for MS were also calculated using multivariate logistic regression analysis across WBC count quartiles (Q1, <5200; Q2, 5200-6100; Q3, 6200-7200; and Q4, ≥7300 cells/μL for boys; Q1, <5200; Q2, 5200-6000; Q3, 6100-7000; and Q4, ≥7100 cells/μL for girls). The prevalence of MS in children and adolescents in Korea was 6.7% (8.5% in boys, 4.5% in girls, P < 0.001). MS was more prevalent in overweight and obese children and adolescents in both boys and girls. The mean WBC counts continuously increased with each additional component of MS in both boys and girls. The ORs (95% CIs) for MS in each WBC quartile were 1.00, 1.56 (0.43-5.67), 4.47 (1.42-14.07), and 5.25 (1.71-16.07) in boys and 1.00, 1.05 (0.15-7.61), 2.89 (0.55-15.17), and 7.47 (1.61-36.67) in girls after adjusting for age, household income, and residential area. Conclusion: In summary, this study shows that a substantial number of children and adolescents in Korea have MS, and elevated WBC count may be a surrogate marker for MS.

AB - Background and aims: To estimate the prevalence of metabolic syndrome (MS) and determine its association with white blood cell (WBC) count as a marker of low-grade systemic inflammation in children and adolescents in Korea. Methods and results: We investigated the prevalence of MS and its association with WBC count in 928 children and adolescents. MS was defined as having 3 or more conditions based on the modified criteria of the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III). The odds ratios (ORs) for MS were also calculated using multivariate logistic regression analysis across WBC count quartiles (Q1, <5200; Q2, 5200-6100; Q3, 6200-7200; and Q4, ≥7300 cells/μL for boys; Q1, <5200; Q2, 5200-6000; Q3, 6100-7000; and Q4, ≥7100 cells/μL for girls). The prevalence of MS in children and adolescents in Korea was 6.7% (8.5% in boys, 4.5% in girls, P < 0.001). MS was more prevalent in overweight and obese children and adolescents in both boys and girls. The mean WBC counts continuously increased with each additional component of MS in both boys and girls. The ORs (95% CIs) for MS in each WBC quartile were 1.00, 1.56 (0.43-5.67), 4.47 (1.42-14.07), and 5.25 (1.71-16.07) in boys and 1.00, 1.05 (0.15-7.61), 2.89 (0.55-15.17), and 7.47 (1.61-36.67) in girls after adjusting for age, household income, and residential area. Conclusion: In summary, this study shows that a substantial number of children and adolescents in Korea have MS, and elevated WBC count may be a surrogate marker for MS.

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