Metabolic syndrome does not impact long-term survival in patients with acute myocardial infarction after successful percutaneous coronary intervention with drug-eluting stents

Ki Bum Won, Byeong Keuk Kim, Hyuk-Jae Chang, Dong Ho Shin, Jung Sun Kim, Young Guk Ko, Donghoon Choi, Jong Won Ha, Myeongki Hong, Yangsoo Jang

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Abstract

Objective This study aimed to evaluate long-term survival according to the presence of metabolic syndrome (MS) in patients with acute myocardial infarction (AMI) undergoing successful percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Background Despite the significance of coronary reperfusion in AMI, the prognostic impact of MS has been investigated under inconsistent reperfusion therapy in AMI patients. Methods and Results Three-year clinical outcomes, including all-cause death and the composite of cardiac death or myocardial infarction, were evaluated according to MS status for 963 patients with AMI treated with successful PCI with DES. This study included 494 subjects with MS (51%) and 469 subjects without MS (49%) the incidence of multivessel disease and the mean number of implanted stents were significantly higher in patients with MS than in patients with non-MS the occurrence of all-cause death (5.9% vs. 6.4%, P = 0.789) and the composite outcomes (5.1% vs. 6.2%, P = 0.485) did not differ significantly between patients with and without MS. Cox regression models revealed that MS had no significant impact on all-cause death (hazard ratio [HR] 0.91; 95% confidence interval [CI] 0.55-1.52; P = 0.726) or the composite outcomes (HR 0.81; 95% CI 0.48-1.39; P = 0.448). Obesity was associated with a decreased risk of all-cause death and the composite outcomes among all MS components. Conclusions No difference was observed in long-term survival according to the presence of MS in patients with AMI after successful PCI with DES. This suggests that reperfusion therapy using PCI with DES is equally beneficial in patients AMI with and without MS. © 2013 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)713-720
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Volume83
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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Drug-Eluting Stents
Percutaneous Coronary Intervention
Myocardial Infarction
Survival
Cause of Death
Reperfusion
Confidence Intervals
Myocardial Reperfusion
Proportional Hazards Models
Stents
Obesity

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

@article{4f4d5f58763745d1a6ebaea454eb6b43,
title = "Metabolic syndrome does not impact long-term survival in patients with acute myocardial infarction after successful percutaneous coronary intervention with drug-eluting stents",
abstract = "Objective This study aimed to evaluate long-term survival according to the presence of metabolic syndrome (MS) in patients with acute myocardial infarction (AMI) undergoing successful percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Background Despite the significance of coronary reperfusion in AMI, the prognostic impact of MS has been investigated under inconsistent reperfusion therapy in AMI patients. Methods and Results Three-year clinical outcomes, including all-cause death and the composite of cardiac death or myocardial infarction, were evaluated according to MS status for 963 patients with AMI treated with successful PCI with DES. This study included 494 subjects with MS (51{\%}) and 469 subjects without MS (49{\%}) the incidence of multivessel disease and the mean number of implanted stents were significantly higher in patients with MS than in patients with non-MS the occurrence of all-cause death (5.9{\%} vs. 6.4{\%}, P = 0.789) and the composite outcomes (5.1{\%} vs. 6.2{\%}, P = 0.485) did not differ significantly between patients with and without MS. Cox regression models revealed that MS had no significant impact on all-cause death (hazard ratio [HR] 0.91; 95{\%} confidence interval [CI] 0.55-1.52; P = 0.726) or the composite outcomes (HR 0.81; 95{\%} CI 0.48-1.39; P = 0.448). Obesity was associated with a decreased risk of all-cause death and the composite outcomes among all MS components. Conclusions No difference was observed in long-term survival according to the presence of MS in patients with AMI after successful PCI with DES. This suggests that reperfusion therapy using PCI with DES is equally beneficial in patients AMI with and without MS. {\circledC} 2013 Wiley Periodicals, Inc.",
author = "Won, {Ki Bum} and Kim, {Byeong Keuk} and Hyuk-Jae Chang and Shin, {Dong Ho} and Kim, {Jung Sun} and Ko, {Young Guk} and Donghoon Choi and Ha, {Jong Won} and Myeongki Hong and Yangsoo Jang",
year = "2014",
month = "1",
day = "1",
doi = "10.1002/ccd.25150",
language = "English",
volume = "83",
pages = "713--720",
journal = "Catheterization and Cardiovascular Interventions",
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TY - JOUR

T1 - Metabolic syndrome does not impact long-term survival in patients with acute myocardial infarction after successful percutaneous coronary intervention with drug-eluting stents

AU - Won, Ki Bum

AU - Kim, Byeong Keuk

AU - Chang, Hyuk-Jae

AU - Shin, Dong Ho

AU - Kim, Jung Sun

AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Ha, Jong Won

AU - Hong, Myeongki

AU - Jang, Yangsoo

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective This study aimed to evaluate long-term survival according to the presence of metabolic syndrome (MS) in patients with acute myocardial infarction (AMI) undergoing successful percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Background Despite the significance of coronary reperfusion in AMI, the prognostic impact of MS has been investigated under inconsistent reperfusion therapy in AMI patients. Methods and Results Three-year clinical outcomes, including all-cause death and the composite of cardiac death or myocardial infarction, were evaluated according to MS status for 963 patients with AMI treated with successful PCI with DES. This study included 494 subjects with MS (51%) and 469 subjects without MS (49%) the incidence of multivessel disease and the mean number of implanted stents were significantly higher in patients with MS than in patients with non-MS the occurrence of all-cause death (5.9% vs. 6.4%, P = 0.789) and the composite outcomes (5.1% vs. 6.2%, P = 0.485) did not differ significantly between patients with and without MS. Cox regression models revealed that MS had no significant impact on all-cause death (hazard ratio [HR] 0.91; 95% confidence interval [CI] 0.55-1.52; P = 0.726) or the composite outcomes (HR 0.81; 95% CI 0.48-1.39; P = 0.448). Obesity was associated with a decreased risk of all-cause death and the composite outcomes among all MS components. Conclusions No difference was observed in long-term survival according to the presence of MS in patients with AMI after successful PCI with DES. This suggests that reperfusion therapy using PCI with DES is equally beneficial in patients AMI with and without MS. © 2013 Wiley Periodicals, Inc.

AB - Objective This study aimed to evaluate long-term survival according to the presence of metabolic syndrome (MS) in patients with acute myocardial infarction (AMI) undergoing successful percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Background Despite the significance of coronary reperfusion in AMI, the prognostic impact of MS has been investigated under inconsistent reperfusion therapy in AMI patients. Methods and Results Three-year clinical outcomes, including all-cause death and the composite of cardiac death or myocardial infarction, were evaluated according to MS status for 963 patients with AMI treated with successful PCI with DES. This study included 494 subjects with MS (51%) and 469 subjects without MS (49%) the incidence of multivessel disease and the mean number of implanted stents were significantly higher in patients with MS than in patients with non-MS the occurrence of all-cause death (5.9% vs. 6.4%, P = 0.789) and the composite outcomes (5.1% vs. 6.2%, P = 0.485) did not differ significantly between patients with and without MS. Cox regression models revealed that MS had no significant impact on all-cause death (hazard ratio [HR] 0.91; 95% confidence interval [CI] 0.55-1.52; P = 0.726) or the composite outcomes (HR 0.81; 95% CI 0.48-1.39; P = 0.448). Obesity was associated with a decreased risk of all-cause death and the composite outcomes among all MS components. Conclusions No difference was observed in long-term survival according to the presence of MS in patients with AMI after successful PCI with DES. This suggests that reperfusion therapy using PCI with DES is equally beneficial in patients AMI with and without MS. © 2013 Wiley Periodicals, Inc.

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U2 - 10.1002/ccd.25150

DO - 10.1002/ccd.25150

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JO - Catheterization and Cardiovascular Interventions

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SN - 1522-1946

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