Metabolic syndrome predicts mortality in non-diabetic patients on continuous ambulatory peritoneal dialysis

Jung Tak Park, Tae Ik Chang, Dong Ki Kim, Jung Eun Lee, Hoon Young Choi, Hyun Wook Kim, Jae Hyun Chang, Sun Young Park, Eunyoung Kim, Tae Hyun Yoo, Dae Suk Han, Shin Wook Kang

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Abstract

Background. Metabolic syndrome is associated with higher morbidity and mortality in the general population, but the corresponding effects in patients on dialysis have not been clearly defined. In this study, we prospectively investigated the effect of metabolic syndrome and its individual components on outcome in non-diabetic peritoneal dialysis (PD) patients.Method. The study subjects included 106 stable non-diabetic PD patients who had been on PD for >3 months. We measured baseline characteristics, blood pressure, fasting blood glucose, lipid profiles and high-sensitivity CRP (hsCRP), and defined metabolic syndrome using the modified National Cholesterol Education Program (Adult Treatment Panel III) criteria. Mortality, technical failure and hospitalization were evaluated during the follow-up period.Results. Metabolic syndrome was present in 50 patients (47.2), and these showed higher baseline hsCRP levels (0.67; 95 CI: 0.50-0.94 versus 1.78 mgdl; 95 CI: 1.21-2.57; P < 0.001). Patients with metabolic syndrome experienced significantly lower 5-year survival rates than patients without (90 versus 67, P = 0.02), although these groups did not differ in peritonitis rates, technical failure or hospitalization. A Cox proportional hazards analysis identified the following as predictors of mortality: metabolic syndrome (RR: 3.39; 95 CI: 1.16-9.94; P = 0.02), baseline albumin (RR: 0.06; 95 CI: 0.01-0.30; P = 0.001) and baseline hsCRP levels (RR: 1.14; 95 CI: 1.07-1.22; P < 0.001).Conclusion. Metabolic syndrome is prevalent and is a risk factor influencing long-term survival in non-diabetic PD patients.

Original languageEnglish
Pages (from-to)599-604
Number of pages6
JournalNephrology Dialysis Transplantation
Volume25
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

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Continuous Ambulatory Peritoneal Dialysis
Peritoneal Dialysis
Mortality
Hospitalization
Peritonitis
Blood Glucose
Dialysis
Albumins
Fasting
Survival Rate
Cholesterol
Blood Pressure
Morbidity
Lipids
Education
Survival
Population

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

Cite this

Park, Jung Tak ; Chang, Tae Ik ; Kim, Dong Ki ; Lee, Jung Eun ; Choi, Hoon Young ; Kim, Hyun Wook ; Chang, Jae Hyun ; Park, Sun Young ; Kim, Eunyoung ; Yoo, Tae Hyun ; Han, Dae Suk ; Kang, Shin Wook. / Metabolic syndrome predicts mortality in non-diabetic patients on continuous ambulatory peritoneal dialysis. In: Nephrology Dialysis Transplantation. 2010 ; Vol. 25, No. 2. pp. 599-604.
@article{4ebec852fc7344eab98d81cddcd01158,
title = "Metabolic syndrome predicts mortality in non-diabetic patients on continuous ambulatory peritoneal dialysis",
abstract = "Background. Metabolic syndrome is associated with higher morbidity and mortality in the general population, but the corresponding effects in patients on dialysis have not been clearly defined. In this study, we prospectively investigated the effect of metabolic syndrome and its individual components on outcome in non-diabetic peritoneal dialysis (PD) patients.Method. The study subjects included 106 stable non-diabetic PD patients who had been on PD for >3 months. We measured baseline characteristics, blood pressure, fasting blood glucose, lipid profiles and high-sensitivity CRP (hsCRP), and defined metabolic syndrome using the modified National Cholesterol Education Program (Adult Treatment Panel III) criteria. Mortality, technical failure and hospitalization were evaluated during the follow-up period.Results. Metabolic syndrome was present in 50 patients (47.2), and these showed higher baseline hsCRP levels (0.67; 95 CI: 0.50-0.94 versus 1.78 mgdl; 95 CI: 1.21-2.57; P < 0.001). Patients with metabolic syndrome experienced significantly lower 5-year survival rates than patients without (90 versus 67, P = 0.02), although these groups did not differ in peritonitis rates, technical failure or hospitalization. A Cox proportional hazards analysis identified the following as predictors of mortality: metabolic syndrome (RR: 3.39; 95 CI: 1.16-9.94; P = 0.02), baseline albumin (RR: 0.06; 95 CI: 0.01-0.30; P = 0.001) and baseline hsCRP levels (RR: 1.14; 95 CI: 1.07-1.22; P < 0.001).Conclusion. Metabolic syndrome is prevalent and is a risk factor influencing long-term survival in non-diabetic PD patients.",
author = "Park, {Jung Tak} and Chang, {Tae Ik} and Kim, {Dong Ki} and Lee, {Jung Eun} and Choi, {Hoon Young} and Kim, {Hyun Wook} and Chang, {Jae Hyun} and Park, {Sun Young} and Eunyoung Kim and Yoo, {Tae Hyun} and Han, {Dae Suk} and Kang, {Shin Wook}",
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Park, JT, Chang, TI, Kim, DK, Lee, JE, Choi, HY, Kim, HW, Chang, JH, Park, SY, Kim, E, Yoo, TH, Han, DS & Kang, SW 2010, 'Metabolic syndrome predicts mortality in non-diabetic patients on continuous ambulatory peritoneal dialysis', Nephrology Dialysis Transplantation, vol. 25, no. 2, pp. 599-604. https://doi.org/10.1093/ndt/gfp498

Metabolic syndrome predicts mortality in non-diabetic patients on continuous ambulatory peritoneal dialysis. / Park, Jung Tak; Chang, Tae Ik; Kim, Dong Ki; Lee, Jung Eun; Choi, Hoon Young; Kim, Hyun Wook; Chang, Jae Hyun; Park, Sun Young; Kim, Eunyoung; Yoo, Tae Hyun; Han, Dae Suk; Kang, Shin Wook.

In: Nephrology Dialysis Transplantation, Vol. 25, No. 2, 01.02.2010, p. 599-604.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Metabolic syndrome predicts mortality in non-diabetic patients on continuous ambulatory peritoneal dialysis

AU - Park, Jung Tak

AU - Chang, Tae Ik

AU - Kim, Dong Ki

AU - Lee, Jung Eun

AU - Choi, Hoon Young

AU - Kim, Hyun Wook

AU - Chang, Jae Hyun

AU - Park, Sun Young

AU - Kim, Eunyoung

AU - Yoo, Tae Hyun

AU - Han, Dae Suk

AU - Kang, Shin Wook

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Background. Metabolic syndrome is associated with higher morbidity and mortality in the general population, but the corresponding effects in patients on dialysis have not been clearly defined. In this study, we prospectively investigated the effect of metabolic syndrome and its individual components on outcome in non-diabetic peritoneal dialysis (PD) patients.Method. The study subjects included 106 stable non-diabetic PD patients who had been on PD for >3 months. We measured baseline characteristics, blood pressure, fasting blood glucose, lipid profiles and high-sensitivity CRP (hsCRP), and defined metabolic syndrome using the modified National Cholesterol Education Program (Adult Treatment Panel III) criteria. Mortality, technical failure and hospitalization were evaluated during the follow-up period.Results. Metabolic syndrome was present in 50 patients (47.2), and these showed higher baseline hsCRP levels (0.67; 95 CI: 0.50-0.94 versus 1.78 mgdl; 95 CI: 1.21-2.57; P < 0.001). Patients with metabolic syndrome experienced significantly lower 5-year survival rates than patients without (90 versus 67, P = 0.02), although these groups did not differ in peritonitis rates, technical failure or hospitalization. A Cox proportional hazards analysis identified the following as predictors of mortality: metabolic syndrome (RR: 3.39; 95 CI: 1.16-9.94; P = 0.02), baseline albumin (RR: 0.06; 95 CI: 0.01-0.30; P = 0.001) and baseline hsCRP levels (RR: 1.14; 95 CI: 1.07-1.22; P < 0.001).Conclusion. Metabolic syndrome is prevalent and is a risk factor influencing long-term survival in non-diabetic PD patients.

AB - Background. Metabolic syndrome is associated with higher morbidity and mortality in the general population, but the corresponding effects in patients on dialysis have not been clearly defined. In this study, we prospectively investigated the effect of metabolic syndrome and its individual components on outcome in non-diabetic peritoneal dialysis (PD) patients.Method. The study subjects included 106 stable non-diabetic PD patients who had been on PD for >3 months. We measured baseline characteristics, blood pressure, fasting blood glucose, lipid profiles and high-sensitivity CRP (hsCRP), and defined metabolic syndrome using the modified National Cholesterol Education Program (Adult Treatment Panel III) criteria. Mortality, technical failure and hospitalization were evaluated during the follow-up period.Results. Metabolic syndrome was present in 50 patients (47.2), and these showed higher baseline hsCRP levels (0.67; 95 CI: 0.50-0.94 versus 1.78 mgdl; 95 CI: 1.21-2.57; P < 0.001). Patients with metabolic syndrome experienced significantly lower 5-year survival rates than patients without (90 versus 67, P = 0.02), although these groups did not differ in peritonitis rates, technical failure or hospitalization. A Cox proportional hazards analysis identified the following as predictors of mortality: metabolic syndrome (RR: 3.39; 95 CI: 1.16-9.94; P = 0.02), baseline albumin (RR: 0.06; 95 CI: 0.01-0.30; P = 0.001) and baseline hsCRP levels (RR: 1.14; 95 CI: 1.07-1.22; P < 0.001).Conclusion. Metabolic syndrome is prevalent and is a risk factor influencing long-term survival in non-diabetic PD patients.

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U2 - 10.1093/ndt/gfp498

DO - 10.1093/ndt/gfp498

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