Abstract
Objective: To screen the metabolomes of both overweight subjects with low visceral fat area (LFO) and high visceral fat area (HFO) to identify potential metabolites that are associated with the different metabolic characteristics. Methods: The metabolic characteristics of 112 overweight (25 kg/m2 ≤ BMI < 30 kg/m2) Korean individuals aged 30 to 65 years were examined. Plasma metabolomic profiling of HFO [visceral fat area (VFA) at L4 ≥ 100 cm2] and LFO (L4 VFA <100 cm2) individuals matched for age, gender, and BMI was performed. Results: HFO subjects showed higher VFA at L1 and L4 than LFO subjects. The HFO group showed higher blood pressure, lipid profile, high-sensitivity C-reactive protein, malondialdehyde, oxidized low-density lipoprotein (LDL), and homeostasis model assessment-insulin resistance and lower high-density lipoprotein-cholesterol levels. In plasma metabolite identification, the HFO group showed significantly higher levels of long-chain (C14:1, C16:1, C16) acylcarnitines (ACs), medium-chain (C12:1, C12) ACs, urobilinogen, docosahexaenoic acid (C22:6ω3), lysoPE (22:6), lysoPC (22:6), lysoPC (22:5), methoxybenzenepropanoic acid, and isodesmosine. All five ACs correlated positively with VFA and oxidized LDL levels and negatively with high-density lipoprotein-cholesterol levels and LDL particle size. Conclusions: Twelve major metabolites, including three long-chain fatty acids and two medium-chain ACs, are important for distinguishing HFO and LFO. Chronic lipid surplus from visceral fat in HFO is likely associated with substantial increases in plasma medium-chain ACs and long-chain fatty acids, which are closely related to atherogenic traits.
| Original language | English |
|---|---|
| Pages (from-to) | 323-331 |
| Number of pages | 9 |
| Journal | Obesity |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2017 Feb 1 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Nutrition and Dietetics
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Metabolites distinguishing visceral fat obesity and atherogenic traits in individuals with overweight. / Baek, Seung Han; Kim, Minkyung; Kim, Minjoo; Kang, Miso; Yoo, Hye Jin; Lee, Nan Hee; Kim, Yong Hwan; Song, Min; Lee, Jong Ho.
In: Obesity, Vol. 25, No. 2, 01.02.2017, p. 323-331.Research output: Contribution to journal › Article
TY - JOUR
T1 - Metabolites distinguishing visceral fat obesity and atherogenic traits in individuals with overweight
AU - Baek, Seung Han
AU - Kim, Minkyung
AU - Kim, Minjoo
AU - Kang, Miso
AU - Yoo, Hye Jin
AU - Lee, Nan Hee
AU - Kim, Yong Hwan
AU - Song, Min
AU - Lee, Jong Ho
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Objective: To screen the metabolomes of both overweight subjects with low visceral fat area (LFO) and high visceral fat area (HFO) to identify potential metabolites that are associated with the different metabolic characteristics. Methods: The metabolic characteristics of 112 overweight (25 kg/m2 ≤ BMI < 30 kg/m2) Korean individuals aged 30 to 65 years were examined. Plasma metabolomic profiling of HFO [visceral fat area (VFA) at L4 ≥ 100 cm2] and LFO (L4 VFA <100 cm2) individuals matched for age, gender, and BMI was performed. Results: HFO subjects showed higher VFA at L1 and L4 than LFO subjects. The HFO group showed higher blood pressure, lipid profile, high-sensitivity C-reactive protein, malondialdehyde, oxidized low-density lipoprotein (LDL), and homeostasis model assessment-insulin resistance and lower high-density lipoprotein-cholesterol levels. In plasma metabolite identification, the HFO group showed significantly higher levels of long-chain (C14:1, C16:1, C16) acylcarnitines (ACs), medium-chain (C12:1, C12) ACs, urobilinogen, docosahexaenoic acid (C22:6ω3), lysoPE (22:6), lysoPC (22:6), lysoPC (22:5), methoxybenzenepropanoic acid, and isodesmosine. All five ACs correlated positively with VFA and oxidized LDL levels and negatively with high-density lipoprotein-cholesterol levels and LDL particle size. Conclusions: Twelve major metabolites, including three long-chain fatty acids and two medium-chain ACs, are important for distinguishing HFO and LFO. Chronic lipid surplus from visceral fat in HFO is likely associated with substantial increases in plasma medium-chain ACs and long-chain fatty acids, which are closely related to atherogenic traits.
AB - Objective: To screen the metabolomes of both overweight subjects with low visceral fat area (LFO) and high visceral fat area (HFO) to identify potential metabolites that are associated with the different metabolic characteristics. Methods: The metabolic characteristics of 112 overweight (25 kg/m2 ≤ BMI < 30 kg/m2) Korean individuals aged 30 to 65 years were examined. Plasma metabolomic profiling of HFO [visceral fat area (VFA) at L4 ≥ 100 cm2] and LFO (L4 VFA <100 cm2) individuals matched for age, gender, and BMI was performed. Results: HFO subjects showed higher VFA at L1 and L4 than LFO subjects. The HFO group showed higher blood pressure, lipid profile, high-sensitivity C-reactive protein, malondialdehyde, oxidized low-density lipoprotein (LDL), and homeostasis model assessment-insulin resistance and lower high-density lipoprotein-cholesterol levels. In plasma metabolite identification, the HFO group showed significantly higher levels of long-chain (C14:1, C16:1, C16) acylcarnitines (ACs), medium-chain (C12:1, C12) ACs, urobilinogen, docosahexaenoic acid (C22:6ω3), lysoPE (22:6), lysoPC (22:6), lysoPC (22:5), methoxybenzenepropanoic acid, and isodesmosine. All five ACs correlated positively with VFA and oxidized LDL levels and negatively with high-density lipoprotein-cholesterol levels and LDL particle size. Conclusions: Twelve major metabolites, including three long-chain fatty acids and two medium-chain ACs, are important for distinguishing HFO and LFO. Chronic lipid surplus from visceral fat in HFO is likely associated with substantial increases in plasma medium-chain ACs and long-chain fatty acids, which are closely related to atherogenic traits.
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U2 - 10.1002/oby.21724
DO - 10.1002/oby.21724
M3 - Article
C2 - 28000430
AN - SCOPUS:85010304601
VL - 25
SP - 323
EP - 331
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 2
ER -