Metabotropic glutamate receptors: Phosphorylation and receptor signaling

Hoon Kim Chul, Jinu Lee, Jae Youn Lee, Katherine W. Roche

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

Metabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of mGluRs affects receptor signaling, trafficking, and desensitization. Here we review the emerging literature on mGluR phosphorylation, signaling, and synaptic function.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalJournal of Neuroscience Research
Volume86
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1

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All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

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