Metallo-β-lactamase-producing Pseudomonas spp. in Korea

High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type

Kyungwon Lee, Ae Ja Park, Moon Yeun Kim, Hee Joo Lee, Ji Hyun Cho, Jung Oak Kang, DongEun Yong, Yunsop Chong, Namhee Ryoon, Seokhoon Jeong, Gyoung Yim Ha, Mi Na Kim, Wee Gyo Lee, Young Ae Hong, Soung Eun Cho, Young Uh, Sook Jin Jang, Myung Hee Lee, Wonkeun Song, Tae Yeal Choi & 7 others Jong Hee Shin, Seong Geun Hong, Young Ah Kim, Dong Hee Cho, Dong Hee Whang, Seungok Lee, Seonghee Lee

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Purpose: Two Korean nationwide studies showed that metallo-β-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp. Materials and Methods: Imipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes. Results: Alleles of MBL genes were detected in 10.8% of 415 Pseudomonas aeruginosa and 66.7% of 12 P. putida isolates from 18 of 24 hospitals/ laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time. Conclusion: Prevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.

Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalYonsei medical journal
Volume50
Issue number3
DOIs
Publication statusPublished - 2009 Jul 30

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Inosine Monophosphate
Korea
Pseudomonas
Pseudomonas aeruginosa
Imipenem
Hospital Laboratories
Genes
Alleles
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Kyungwon ; Park, Ae Ja ; Kim, Moon Yeun ; Lee, Hee Joo ; Cho, Ji Hyun ; Kang, Jung Oak ; Yong, DongEun ; Chong, Yunsop ; Ryoon, Namhee ; Jeong, Seokhoon ; Ha, Gyoung Yim ; Kim, Mi Na ; Lee, Wee Gyo ; Hong, Young Ae ; Cho, Soung Eun ; Uh, Young ; Jang, Sook Jin ; Lee, Myung Hee ; Song, Wonkeun ; Choi, Tae Yeal ; Shin, Jong Hee ; Hong, Seong Geun ; Kim, Young Ah ; Cho, Dong Hee ; Whang, Dong Hee ; Lee, Seungok ; Lee, Seonghee. / Metallo-β-lactamase-producing Pseudomonas spp. in Korea : High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type. In: Yonsei medical journal. 2009 ; Vol. 50, No. 3. pp. 335-339.
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title = "Metallo-β-lactamase-producing Pseudomonas spp. in Korea: High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type",
abstract = "Purpose: Two Korean nationwide studies showed that metallo-β-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp. Materials and Methods: Imipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes. Results: Alleles of MBL genes were detected in 10.8{\%} of 415 Pseudomonas aeruginosa and 66.7{\%} of 12 P. putida isolates from 18 of 24 hospitals/ laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time. Conclusion: Prevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.",
author = "Kyungwon Lee and Park, {Ae Ja} and Kim, {Moon Yeun} and Lee, {Hee Joo} and Cho, {Ji Hyun} and Kang, {Jung Oak} and DongEun Yong and Yunsop Chong and Namhee Ryoon and Seokhoon Jeong and Ha, {Gyoung Yim} and Kim, {Mi Na} and Lee, {Wee Gyo} and Hong, {Young Ae} and Cho, {Soung Eun} and Young Uh and Jang, {Sook Jin} and Lee, {Myung Hee} and Wonkeun Song and Choi, {Tae Yeal} and Shin, {Jong Hee} and Hong, {Seong Geun} and Kim, {Young Ah} and Cho, {Dong Hee} and Whang, {Dong Hee} and Seungok Lee and Seonghee Lee",
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Lee, K, Park, AJ, Kim, MY, Lee, HJ, Cho, JH, Kang, JO, Yong, D, Chong, Y, Ryoon, N, Jeong, S, Ha, GY, Kim, MN, Lee, WG, Hong, YA, Cho, SE, Uh, Y, Jang, SJ, Lee, MH, Song, W, Choi, TY, Shin, JH, Hong, SG, Kim, YA, Cho, DH, Whang, DH, Lee, S & Lee, S 2009, 'Metallo-β-lactamase-producing Pseudomonas spp. in Korea: High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type', Yonsei medical journal, vol. 50, no. 3, pp. 335-339. https://doi.org/10.3349/ymj.2009.50.3.335

Metallo-β-lactamase-producing Pseudomonas spp. in Korea : High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type. / Lee, Kyungwon; Park, Ae Ja; Kim, Moon Yeun; Lee, Hee Joo; Cho, Ji Hyun; Kang, Jung Oak; Yong, DongEun; Chong, Yunsop; Ryoon, Namhee; Jeong, Seokhoon; Ha, Gyoung Yim; Kim, Mi Na; Lee, Wee Gyo; Hong, Young Ae; Cho, Soung Eun; Uh, Young; Jang, Sook Jin; Lee, Myung Hee; Song, Wonkeun; Choi, Tae Yeal; Shin, Jong Hee; Hong, Seong Geun; Kim, Young Ah; Cho, Dong Hee; Whang, Dong Hee; Lee, Seungok; Lee, Seonghee.

In: Yonsei medical journal, Vol. 50, No. 3, 30.07.2009, p. 335-339.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Metallo-β-lactamase-producing Pseudomonas spp. in Korea

T2 - High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type

AU - Lee, Kyungwon

AU - Park, Ae Ja

AU - Kim, Moon Yeun

AU - Lee, Hee Joo

AU - Cho, Ji Hyun

AU - Kang, Jung Oak

AU - Yong, DongEun

AU - Chong, Yunsop

AU - Ryoon, Namhee

AU - Jeong, Seokhoon

AU - Ha, Gyoung Yim

AU - Kim, Mi Na

AU - Lee, Wee Gyo

AU - Hong, Young Ae

AU - Cho, Soung Eun

AU - Uh, Young

AU - Jang, Sook Jin

AU - Lee, Myung Hee

AU - Song, Wonkeun

AU - Choi, Tae Yeal

AU - Shin, Jong Hee

AU - Hong, Seong Geun

AU - Kim, Young Ah

AU - Cho, Dong Hee

AU - Whang, Dong Hee

AU - Lee, Seungok

AU - Lee, Seonghee

PY - 2009/7/30

Y1 - 2009/7/30

N2 - Purpose: Two Korean nationwide studies showed that metallo-β-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp. Materials and Methods: Imipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes. Results: Alleles of MBL genes were detected in 10.8% of 415 Pseudomonas aeruginosa and 66.7% of 12 P. putida isolates from 18 of 24 hospitals/ laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time. Conclusion: Prevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.

AB - Purpose: Two Korean nationwide studies showed that metallo-β-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp. Materials and Methods: Imipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes. Results: Alleles of MBL genes were detected in 10.8% of 415 Pseudomonas aeruginosa and 66.7% of 12 P. putida isolates from 18 of 24 hospitals/ laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time. Conclusion: Prevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.

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