Metallo-β-lactamase-producing Pseudomonas spp. in Korea: High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type

Kyungwon Lee, Ae Ja Park, Moon Yeun Kim, Hee Joo Lee, Ji Hyun Cho, Jung Oak Kang, Dongeun Yong, Yunsop Chong, Namhee Ryoon, Seok Hoon Jeong, Gyoung Yim Ha, Mi Na Kim, Wee Gyo Lee, Young Ae Hong, Soung Eun Cho, Young Uh, Sook Jin Jang, Myung Hee Lee, Wonkeun Song, Tae Yeal ChoiJong Hee Shin, Seong Geun Hong, Young Ah Kim, Dong Hee Cho, Dong Hee Whang, Seungok Lee, Seonghee Lee

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Abstract

Purpose: Two Korean nationwide studies showed that metallo-β-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp. Materials and Methods: Imipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes. Results: Alleles of MBL genes were detected in 10.8% of 415 Pseudomonas aeruginosa and 66.7% of 12 P. putida isolates from 18 of 24 hospitals/ laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time. Conclusion: Prevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.

Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalYonsei medical journal
Volume50
Issue number3
DOIs
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Lee, K., Park, A. J., Kim, M. Y., Lee, H. J., Cho, J. H., Kang, J. O., Yong, D., Chong, Y., Ryoon, N., Jeong, S. H., Ha, G. Y., Kim, M. N., Lee, W. G., Hong, Y. A., Cho, S. E., Uh, Y., Jang, S. J., Lee, M. H., Song, W., ... Lee, S. (2009). Metallo-β-lactamase-producing Pseudomonas spp. in Korea: High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type. Yonsei medical journal, 50(3), 335-339. https://doi.org/10.3349/ymj.2009.50.3.335