Metasurfaces for biomedical applications: Imaging and sensing from a nanophotonics perspective

Shuyan Zhang, Chi Lok Wong, Shuwen Zeng, Renzhe Bi, Kolvyn Tai, Kishan Dholakia, Malini Olivo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Metasurface is a recently developed nanophotonics concept to manipulate the properties of light by replacing conventional bulky optical components with ultrathin (more than 104 times thinner) flat optical components. Since the first demonstration of metasurfaces in 2011, they have attracted tremendous interest in the consumer optics and electronics industries. Recently, metasurface-empowered novel bioimaging and biosensing tools have emerged and been reported. Given the recent advances in metasurfaces in biomedical engineering, this review article covers the state of the art for this technology and provides a comprehensive interdisciplinary perspective on this field. The topics that we have covered include metasurfaces for chiral imaging, endoscopic optical coherence tomography, fluorescent imaging, superresolution imaging, magnetic resonance imaging, quantitative phase imaging, sensing of antibodies, proteins, DNAs, cells, and cancer biomarkers. Future directions are discussed in twofold: Application-specific biomedical metasurfaces and bioinspired metasurface devices. Perspectives on challenges and opportunities of metasurfaces, biophotonics, and translational biomedical devices are also provided. The objective of this review article is to inform and stimulate interdisciplinary research: Firstly, by introducing the metasurface concept to the biomedical community; and secondly by assisting the metasurface community to understand the needs and realize the opportunities in the medical fields. In addition, this article provides two knowledge boxes describing the design process of a metasurface lens and the performance matrix of a biosensor, which serve as a "crash-course" introduction to those new to both fields.

Original languageEnglish
Title of host publicationFrontiers in Optics and Photonics
Publisherde Gruyter
Pages265-299
Number of pages35
ISBN (Electronic)9783110710687
ISBN (Print)9783110709735
DOIs
Publication statusPublished - 2021 Jun 8

Bibliographical note

Publisher Copyright:
© 2021 Walter de Gruyter GmbH, Berlin/Boston. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

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