Methionine analogues as inhibitors of methionyl-tRNA synthetase

Jeewoo Lee; Mee Kyoung Kang; Moon Woo Chun; Yeong Joon Jo; Jin Hwan Kwak; Sunghoon Kim

doi:10.1016/S0960-894X(98)00642-8

Methionine analogues as inhibitors of methionyl-tRNA synthetase

Jeewoo Lee, Mee Kyoung Kang, Moon Woo Chun, Yeong Joon Jo, Jin Hwan Kwak, Sunghoon Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with K(i) = 19 μM and showed a growth inhibition against E. coli JM 109, P. vulganis 6059 and C. freundii 8090.

Original language	English
Pages (from-to)	3511-3514
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	24
DOIs	https://doi.org/10.1016/S0960-894X(98)00642-8
Publication status	Published - 1998 Dec 15

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(98)00642-8

Cite this

@article{c4505c058bbf42099248f60581cb68f8,

title = "Methionine analogues as inhibitors of methionyl-tRNA synthetase",

abstract = "A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with K(i) = 19 μM and showed a growth inhibition against E. coli JM 109, P. vulganis 6059 and C. freundii 8090.",

author = "Jeewoo Lee and Kang, {Mee Kyoung} and Chun, {Moon Woo} and Jo, {Yeong Joon} and Kwak, {Jin Hwan} and Sunghoon Kim",

year = "1998",

month = dec,

day = "15",

doi = "10.1016/S0960-894X(98)00642-8",

language = "English",

volume = "8",

pages = "3511--3514",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "24",

}

TY - JOUR

T1 - Methionine analogues as inhibitors of methionyl-tRNA synthetase

AU - Lee, Jeewoo

AU - Kang, Mee Kyoung

AU - Chun, Moon Woo

AU - Jo, Yeong Joon

AU - Kwak, Jin Hwan

AU - Kim, Sunghoon

PY - 1998/12/15

Y1 - 1998/12/15

N2 - A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with K(i) = 19 μM and showed a growth inhibition against E. coli JM 109, P. vulganis 6059 and C. freundii 8090.

AB - A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with K(i) = 19 μM and showed a growth inhibition against E. coli JM 109, P. vulganis 6059 and C. freundii 8090.

UR - http://www.scopus.com/inward/record.url?scp=0344177555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344177555&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(98)00642-8

DO - 10.1016/S0960-894X(98)00642-8

M3 - Article

C2 - 9934462

AN - SCOPUS:0344177555

SN - 0960-894X

VL - 8

SP - 3511

EP - 3514

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Methionine analogues as inhibitors of methionyl-tRNA synthetase

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this