Methionine analogues as inhibitors of methionyl-tRNA synthetase

Jeewoo Lee, Mee Kyoung Kang, Moon Woo Chun, Yeong Joon Jo, Jin Hwan Kwak, Sunghoon Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with K(i) = 19 μM and showed a growth inhibition against E. coli JM 109, P. vulganis 6059 and C. freundii 8090.

Original languageEnglish
Pages (from-to)3511-3514
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number24
DOIs
Publication statusPublished - 1998 Dec 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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