Abstract
Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'- isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichi coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.
Original language | English |
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Pages (from-to) | 1365-1370 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 9 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1999 May 17 |
Bibliographical note
Funding Information:This study was supported in part by a grant (# HMP-97-D-4-0014) of the '97 Good Health R&D Project, Ministry of Health & Welfare, and by a grant of National Creative Research Initiatives from Ministry of Science and Technology, R.O.K.
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry