Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase

Jeewoo Lee, Uk Kang Sang, Kyoung Kang Mee, Woo Chun Moon, Joon Jo Yeong, Hwan Kwak Jin, Sunghoon Kim

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'- isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichi coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.

Original languageEnglish
Pages (from-to)1365-1370
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number10
DOIs
Publication statusPublished - 1999 May 17

Bibliographical note

Funding Information:
This study was supported in part by a grant (# HMP-97-D-4-0014) of the '97 Good Health R&D Project, Ministry of Health & Welfare, and by a grant of National Creative Research Initiatives from Ministry of Science and Technology, R.O.K.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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