Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase

Jeewoo Lee; Uk Kang Sang; Kyoung Kang Mee; Woo Chun Moon; Joon Jo Yeong; Hwan Kwak Jin; Sunghoon Kim

doi:10.1016/S0960-894X(99)00206-1

Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase

Jeewoo Lee, Uk Kang Sang, Kyoung Kang Mee, Woo Chun Moon, Joon Jo Yeong, Hwan Kwak Jin, Sunghoon Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'- isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichi coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.

Original language	English
Pages (from-to)	1365-1370
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(99)00206-1
Publication status	Published - 1999 May 17

Bibliographical note

Funding Information:
This study was supported in part by a grant (# HMP-97-D-4-0014) of the '97 Good Health R&D Project, Ministry of Health & Welfare, and by a grant of National Creative Research Initiatives from Ministry of Science and Technology, R.O.K.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase",

abstract = "Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'- isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichi coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.",

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AU - Lee, Jeewoo

AU - Sang, Uk Kang

AU - Mee, Kyoung Kang

AU - Moon, Woo Chun

AU - Yeong, Joon Jo

AU - Jin, Hwan Kwak

AU - Kim, Sunghoon

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