Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase

Jeewoo Lee; Uk Kang Sang; Kyoung Kang Mee; Woo Chun Moon; Joon Jo Yeong; Hwan Kwak Jin; Sunghoon Kim

doi:10.1016/S0960-894X(99)00206-1

Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase

Jeewoo Lee, Uk Kang Sang, Kyoung Kang Mee, Woo Chun Moon, Joon Jo Yeong, Hwan Kwak Jin, Sunghoon Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'- isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichi coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.

Original language	English
Pages (from-to)	1365-1370
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(99)00206-1
Publication status	Published - 1999 May 17

Bibliographical note

Funding Information:
This study was supported in part by a grant (# HMP-97-D-4-0014) of the '97 Good Health R&D Project, Ministry of Health & Welfare, and by a grant of National Creative Research Initiatives from Ministry of Science and Technology, R.O.K.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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abstract = "Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'- isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichi coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.",

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AU - Yeong, Joon Jo

AU - Jin, Hwan Kwak

AU - Kim, Sunghoon

N1 - Funding Information: This study was supported in part by a grant (# HMP-97-D-4-0014) of the '97 Good Health R&D Project, Ministry of Health & Welfare, and by a grant of National Creative Research Initiatives from Ministry of Science and Technology, R.O.K.

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N2 - Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'- isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichi coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.

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Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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