Method of reconstruction governs iron metabolism after gastrectomy for patients with gastric cancer

Joong Ho Lee, Woo Jin Hyung, Hyoung Il Kim, Yoo Min Kim, Taeil Son, Naoki Okumura, Yanfeng Hu, Choong Bai Kim, Sung Hoon Noh

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

OBJECTIVE:: Anemia after gastrectomy is commonly neglected by clinicians despite being an important and frequent long-term metabolic sequela. We hypothesized that the incidence and timing of the occurrence of iron deficiency after gastrectomy is closely associated with the extent of gastrectomy and the reconstruction method, and we investigated the treatment outcomes of iron supplementation to understand iron metabolism and determine the optimal reconstruction method after gastrectomy. PATIENTS AND METHODS:: Using a prospective gastric cancer database, we identified 381 patients with early gastric cancer with complete hematologic parameters who underwent gastrectomy between January 2004 and May 2008. Kaplan-Meier methods, Cox regression, and logistic regression were used to evaluate the associations of the extent of gastrectomy and reconstruction method with iron metabolism. RESULTS:: The prevalence of iron deficiency 3 years after gastrectomy was 69.1%, and iron-deficiency anemia was observed in 31.0% of patients. Iron deficiency developed in 64.8% and 90.5% of patients after distal gastrectomy and total gastrectomy within 3 years after surgery (P < 0.0001), respectively. Iron deficiency was significantly more frequent in women than in men (P < 0.0001) and after gastrojejunostomy than after gastroduodenostomy (P < 0.0001). Serum ferritin levels were different according to the extent of gastrectomy and reconstruction method. The proportion of patients treated for iron-deficiency anemia was also significantly different according to the extent of gastrectomy (P = 0.020). CONCLUSIONS:: Iron deficiency occurs in most patients with gastric cancer after gastrectomy, and its incidence was different according to the extent of gastrectomy and reconstruction method. To improve iron metabolism after distal gastrectomy, gastroduodenostomy would be the method of reconstruction whenever possible.

Original languageEnglish
Pages (from-to)964-969
Number of pages6
JournalAnnals of surgery
Volume258
Issue number6
DOIs
Publication statusPublished - 2013 Dec

All Science Journal Classification (ASJC) codes

  • Surgery

Fingerprint Dive into the research topics of 'Method of reconstruction governs iron metabolism after gastrectomy for patients with gastric cancer'. Together they form a unique fingerprint.

  • Cite this

    Lee, J. H., Hyung, W. J., Kim, H. I., Kim, Y. M., Son, T., Okumura, N., Hu, Y., Kim, C. B., & Noh, S. H. (2013). Method of reconstruction governs iron metabolism after gastrectomy for patients with gastric cancer. Annals of surgery, 258(6), 964-969. https://doi.org/10.1097/SLA.0b013e31827eebc1