Micellar phytosterols effectively reduce cholesterol absorption at low doses

Min Jeong Shin, Ho Lee Jong, Yangsoo Jang, Cha Lee Kim Yang, Eunju Park, Mee Kim Kyung, Chul Chung Bong, Namsik Chung

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The objective of this study was to evaluate the effects of micellar phytosterols on cholesterol absorption in humans. Methods: 24 healthy adults (mean age 37 years, 16 women and 8 men) underwent four cholesterol-absorption tests to compare the effects of micellar phytosterols supplement containing 500, 300, 200 mg phytosterols and placebo on cholesterol absorption in a cross-over design. Individual absorption tests were separated by 2 weeks. Using the single oral isotope method, inhibition of cholesterol absorption was determined by gas-chromatography mass spectrometry measurement of the differences in plasma hexadeuterated cholesterol enrichment 4 days after test meals with or without phytosterols. Each test meal provided 500 kcal and 89 mg cholesterol including 40 mg tracer cholesterol. We used a general linear mixed model with SAS to test the significance of treatment effect. Results: Micellar phytosterols had a significant overall effect on cholesterol absorption (p = 0.0002), reduced cholesterol absorption by 23.3% at a dose of 300 mg phytosterols (p = 0.0004) and by 32.0% at a dose of 500 mg phytosterols (p = 0.0001) compared with the placebo. The effect of 200 mg treatment did not reach statistical significance but there was a tendency (p = 0.052). Conclusion: Water-dispersible, micellar phytosterols reduced cholesterol absorption effectively at very low doses.

Original languageEnglish
Pages (from-to)346-351
Number of pages6
JournalAnnals of Nutrition and Metabolism
Volume49
Issue number5
DOIs
Publication statusPublished - 2005 Sep 1

Fingerprint

Phytosterols
Cholesterol
Meals
Placebos
Isotopes
Gas Chromatography-Mass Spectrometry
Cross-Over Studies
Linear Models

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Shin, Min Jeong ; Jong, Ho Lee ; Jang, Yangsoo ; Yang, Cha Lee Kim ; Park, Eunju ; Kyung, Mee Kim ; Bong, Chul Chung ; Chung, Namsik. / Micellar phytosterols effectively reduce cholesterol absorption at low doses. In: Annals of Nutrition and Metabolism. 2005 ; Vol. 49, No. 5. pp. 346-351.
@article{faa1fe4bd440417d812ebbf143b12e32,
title = "Micellar phytosterols effectively reduce cholesterol absorption at low doses",
abstract = "Background: The objective of this study was to evaluate the effects of micellar phytosterols on cholesterol absorption in humans. Methods: 24 healthy adults (mean age 37 years, 16 women and 8 men) underwent four cholesterol-absorption tests to compare the effects of micellar phytosterols supplement containing 500, 300, 200 mg phytosterols and placebo on cholesterol absorption in a cross-over design. Individual absorption tests were separated by 2 weeks. Using the single oral isotope method, inhibition of cholesterol absorption was determined by gas-chromatography mass spectrometry measurement of the differences in plasma hexadeuterated cholesterol enrichment 4 days after test meals with or without phytosterols. Each test meal provided 500 kcal and 89 mg cholesterol including 40 mg tracer cholesterol. We used a general linear mixed model with SAS to test the significance of treatment effect. Results: Micellar phytosterols had a significant overall effect on cholesterol absorption (p = 0.0002), reduced cholesterol absorption by 23.3{\%} at a dose of 300 mg phytosterols (p = 0.0004) and by 32.0{\%} at a dose of 500 mg phytosterols (p = 0.0001) compared with the placebo. The effect of 200 mg treatment did not reach statistical significance but there was a tendency (p = 0.052). Conclusion: Water-dispersible, micellar phytosterols reduced cholesterol absorption effectively at very low doses.",
author = "Shin, {Min Jeong} and Jong, {Ho Lee} and Yangsoo Jang and Yang, {Cha Lee Kim} and Eunju Park and Kyung, {Mee Kim} and Bong, {Chul Chung} and Namsik Chung",
year = "2005",
month = "9",
day = "1",
doi = "10.1159/000087880",
language = "English",
volume = "49",
pages = "346--351",
journal = "Annals of Nutrition and Metabolism",
issn = "0250-6807",
publisher = "S. Karger AG",
number = "5",

}

Micellar phytosterols effectively reduce cholesterol absorption at low doses. / Shin, Min Jeong; Jong, Ho Lee; Jang, Yangsoo; Yang, Cha Lee Kim; Park, Eunju; Kyung, Mee Kim; Bong, Chul Chung; Chung, Namsik.

In: Annals of Nutrition and Metabolism, Vol. 49, No. 5, 01.09.2005, p. 346-351.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Micellar phytosterols effectively reduce cholesterol absorption at low doses

AU - Shin, Min Jeong

AU - Jong, Ho Lee

AU - Jang, Yangsoo

AU - Yang, Cha Lee Kim

AU - Park, Eunju

AU - Kyung, Mee Kim

AU - Bong, Chul Chung

AU - Chung, Namsik

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Background: The objective of this study was to evaluate the effects of micellar phytosterols on cholesterol absorption in humans. Methods: 24 healthy adults (mean age 37 years, 16 women and 8 men) underwent four cholesterol-absorption tests to compare the effects of micellar phytosterols supplement containing 500, 300, 200 mg phytosterols and placebo on cholesterol absorption in a cross-over design. Individual absorption tests were separated by 2 weeks. Using the single oral isotope method, inhibition of cholesterol absorption was determined by gas-chromatography mass spectrometry measurement of the differences in plasma hexadeuterated cholesterol enrichment 4 days after test meals with or without phytosterols. Each test meal provided 500 kcal and 89 mg cholesterol including 40 mg tracer cholesterol. We used a general linear mixed model with SAS to test the significance of treatment effect. Results: Micellar phytosterols had a significant overall effect on cholesterol absorption (p = 0.0002), reduced cholesterol absorption by 23.3% at a dose of 300 mg phytosterols (p = 0.0004) and by 32.0% at a dose of 500 mg phytosterols (p = 0.0001) compared with the placebo. The effect of 200 mg treatment did not reach statistical significance but there was a tendency (p = 0.052). Conclusion: Water-dispersible, micellar phytosterols reduced cholesterol absorption effectively at very low doses.

AB - Background: The objective of this study was to evaluate the effects of micellar phytosterols on cholesterol absorption in humans. Methods: 24 healthy adults (mean age 37 years, 16 women and 8 men) underwent four cholesterol-absorption tests to compare the effects of micellar phytosterols supplement containing 500, 300, 200 mg phytosterols and placebo on cholesterol absorption in a cross-over design. Individual absorption tests were separated by 2 weeks. Using the single oral isotope method, inhibition of cholesterol absorption was determined by gas-chromatography mass spectrometry measurement of the differences in plasma hexadeuterated cholesterol enrichment 4 days after test meals with or without phytosterols. Each test meal provided 500 kcal and 89 mg cholesterol including 40 mg tracer cholesterol. We used a general linear mixed model with SAS to test the significance of treatment effect. Results: Micellar phytosterols had a significant overall effect on cholesterol absorption (p = 0.0002), reduced cholesterol absorption by 23.3% at a dose of 300 mg phytosterols (p = 0.0004) and by 32.0% at a dose of 500 mg phytosterols (p = 0.0001) compared with the placebo. The effect of 200 mg treatment did not reach statistical significance but there was a tendency (p = 0.052). Conclusion: Water-dispersible, micellar phytosterols reduced cholesterol absorption effectively at very low doses.

UR - http://www.scopus.com/inward/record.url?scp=24744452567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24744452567&partnerID=8YFLogxK

U2 - 10.1159/000087880

DO - 10.1159/000087880

M3 - Article

C2 - 16127299

AN - SCOPUS:24744452567

VL - 49

SP - 346

EP - 351

JO - Annals of Nutrition and Metabolism

JF - Annals of Nutrition and Metabolism

SN - 0250-6807

IS - 5

ER -