Microarray analysis of the gene expression profiles of SL2 cells stimulated by LPS/PGN and curdlan

Li Hua Jin, Jung Kyoon Choi, Hwan Sung Cho, Jaewon Shim, Young Joon Kim

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Abstract

Essential aspects of the innate immune response to microbial infection appear to be conserved between insects and mammals. In order to identify new Drosophila melanogaster genes involved in the immune response, we performed gene expression profiling of Drosophila SL2 cells stimulated with bacterial (LPS/PGN) or fungal (curdlan) components using a cDNA microarray that contained 5,405 Drosophila cDNAs. We found that some genes were similarly regulated by LPS/PGN and curdlan. However, a large number, belonging to the functional classes of cell organization, development, signal transduction, morphogenesis, cell cycle, and DNA replication, displayed significant differences in their transcription profiles between the two treatments, demonstrating that bacterial and fungal components induce different immune response even in an in vitro cell system.

Original languageEnglish
Pages (from-to)553-558
Number of pages6
JournalMolecules and Cells
Volume25
Issue number4
Publication statusPublished - 2008 Jun 30

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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