Microarray Analysis on Odontogenesis-related-genes in Mouse Dental Papillae

Takashi Muramatsu; Hodaka Sasaki; Masaki Shimono; Hitoshi Yamamoto; Yohko Kohno; Sung Won Cho; Han Sung Jung

doi:10.2485/jhtb.14.180

Microarray Analysis on Odontogenesis-related-genes in Mouse Dental Papillae

Takashi Muramatsu, Hodaka Sasaki, Masaki Shimono, Hitoshi Yamamoto, Yohko Kohno, Sung Won Cho, Han Sung Jung

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In the present study, we examined to identify downregulated genes between pre- and post dental papillae by microarray analysis in order to identify genes involved in tooth morphogenesis. The dental papilla tissues obtained from E16, E18, P03 and P10 of ICR mice were used for microarray analysis. Microarray analysis showed that the number of upregulated genes ranged from 860 to 2214 from E16 to P10 and was decreased following the tooth morphogenesis. On the other hand, the number of downregulated genes ranged from 1337 to 2924, and number of downregulated genes was the highest (2924 genes) during E18 and P3. The results suggest that the reduced or disappeared genes in dental papilla between P0 and P3 are associated with forming and calcifying the dentin of tooth crown and regeneration of tooth.

Original language	English
Pages (from-to)	180-182
Number of pages	3
Journal	Journal of Hard Tissue Biology
Volume	14
Issue number	2
DOIs	https://doi.org/10.2485/jhtb.14.180
Publication status	Published - 2005 Jan

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Biochemistry
Biomaterials
Orthopedics and Sports Medicine
Dentistry(all)
Cell Biology

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abstract = "In the present study, we examined to identify downregulated genes between pre- and post dental papillae by microarray analysis in order to identify genes involved in tooth morphogenesis. The dental papilla tissues obtained from E16, E18, P03 and P10 of ICR mice were used for microarray analysis. Microarray analysis showed that the number of upregulated genes ranged from 860 to 2214 from E16 to P10 and was decreased following the tooth morphogenesis. On the other hand, the number of downregulated genes ranged from 1337 to 2924, and number of downregulated genes was the highest (2924 genes) during E18 and P3. The results suggest that the reduced or disappeared genes in dental papilla between P0 and P3 are associated with forming and calcifying the dentin of tooth crown and regeneration of tooth.",

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AU - Muramatsu, Takashi

AU - Sasaki, Hodaka

AU - Shimono, Masaki

AU - Yamamoto, Hitoshi

AU - Kohno, Yohko

AU - Cho, Sung Won

AU - Jung, Han Sung

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Microarray Analysis on Odontogenesis-related-genes in Mouse Dental Papillae

Abstract

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