Microbe profile: Cryptococcus neoformans species complex

Yong Sun Bahn, Sheng Sun, Joseph Heitman, Xiaorong Lin

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Cryptococcus neoformans is a lethal fungus disguised in a polysaccharide coat. It can remain dormant in the host for decades prior to reactivation, causing systemic cryptococcosis in humans and other mammals. Cryptococcus deploys a multitude of traits to adapt to and survive within the host, including immunosuppression, an ability to replicate intra-and extra-cellularly in phagocytes, changes in morphology and ploidy, a predilection to infect the CNS, and the capacity to utilize neurotransmitters and unique carbon sources available in the brain. These pathogenic strategies displayed by this fungus might have evolved through its interactions with microbial predators in the environment.

Original languageEnglish
Article number000973
Pages (from-to)797-799
Number of pages3
JournalMicrobiology (United Kingdom)
Volume166
Issue number9
DOIs
Publication statusPublished - 2020

Bibliographical note

Funding Information:
This work was supported by NIH/National Institute of Allergy and Infectious Diseases (NIAID) R37 MERIT Award AI39115-23, R01 Grant AI50113-16, and R01 Grant AI112595-04 to J.H. J.H. is Co-Director and Fellow of Canadian Institute for Advanced Research (CIFAR) programme Fungal Kingdom: Threats and Opportunities. X.L. is supported by NIH R01 Grant AI140719. Y.S.B. is supported by grants 916006–2 and 918012–4 from the Strategic Initiative for Microbiomes in Agriculture and Food, Ministry of Agriculture, Food and Rural Affairs of Korea, and in part, by grants 2016R1E1A1A01943365 and 2018R1A5A1025077 from the National Research Foundation, Ministry of Science and ICT of Korea.

Funding Information:
This work was supported by NIH/National Institute of Allergy and Infectious Diseases (NIAID) R37 MERIT Award AI39115-23, R01 Grant AI50113-16, and R01 Grant AI112595-04 to J.H. J.H. is Co-Director and Fellow of Canadian Institute for Advanced Research (CIFAR) programme Fungal Kingdom: Threats and Opportunities. X.L. is supported by NIH R01 Grant AI140719. Y.S.B. is supported by grants 916006?2 and 918012?4 from the Strategic Initiative for Microbiomes in Agriculture and Food, Ministry of Agriculture, Food and Rural Affairs of Korea, and in part, by grants 2016R1E1A1A01943365 and 2018R1A5A1025077 from the National Research Foundation, Ministry of Science and ICT of Korea.

Publisher Copyright:
© 2020 The Authors.

All Science Journal Classification (ASJC) codes

  • Microbiology

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