Microbial degradation and toxicity of hexahydro-1,3,5-trinitro-1,3,5-triazine

Muhammad Imran Khan, Jaejin Lee, Joonhong Park

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)


In the present work, current knowledge on the potential fate, microbial degradation, and toxicity of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was thoroughly reviewed, focusing on the toxicological assessment of a variety of potential RDX degradation pathways in bacteria and fungi. The present review on microbial degradation pathways and toxicities of degradation intermediates suggests that, among aerobic RDX degradation pathways, the one via denitration may be preferred in a toxicological perspective, and that among anaerobic pathways, those forming 4-nitro-2,4-diazabutanal (NDAB) via ring cleavage of 1-nitroso-3,5-dinitro-1,3,5-triazinane (MNX) may be toxicologically advantageous owing to its potential mineralization under partial or complete anoxic conditions. These findings provide important information on RDX-degrading microbial pathways, toxicologically most suitable to be stimulated in contaminated fields.

Original languageEnglish
Pages (from-to)1311-1323
Number of pages13
JournalJournal of microbiology and biotechnology
Issue number10
Publication statusPublished - 2012 Oct

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology


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