Microcellular environmental regulation of silver nanoparticles in cancer therapy: A critical review

Ganesan Raja, Yoon Kwan Jang, Jung Soo Suh, Heon Su Kim, Sang Hyun Ahn, Tae Jin Kim

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Silver nanoparticles (AgNPs) play significant roles in various cancer cells such as functional heterogeneity, microenvironmental differences, and reversible changes in cell properties (e.g., chemotherapy). There is a lack of targets for processes involved in tumor cellular heterogeneity, such as metabolic clampdown, cytotoxicity, and genotoxicity, which hinders microenvironmental biology. Proteogenomics and chemical metabolomics are important tools that can be used to study proteins/genes and metabolites in cells, respectively. Chemical metabolomics have many advantages over genomics, transcriptomics, and proteomics in anticancer therapy. However, recent studies with AgNPs have revealed considerable genomic and proteomic changes, particularly in genes involved in tumor suppression, apoptosis, and oxidative stress. Metabolites interact biochemically with energy storage, neurotransmitters, and antioxidant defense systems. Mechanobiological studies of AgNPs in cancer metabolomics suggest that AgNPs may be promising tools that can be exploited to develop more robust and effective adaptive anticancer therapies. Herein, we present a proof-of-concept review for AgNPs-based proteogenomics and chemical metabolomics from various tumor cells with the help of several technologies, suggesting their promising use as drug carriers for cancer therapy.

Original languageEnglish
Article number664
Pages (from-to)1-33
Number of pages33
JournalCancers
Volume12
Issue number3
DOIs
Publication statusPublished - 2020 Mar

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through National Research Foundation of Korea (NRF), funded by the Ministry of Education (2017R1D1A1B03035622). Acknowledgments: We thanks to BK21 Plus Research Group for Longevity and Marine Biotechnology for sponsoring this project.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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