Microchip-based electrochromatography: Designs and applications

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Different techniques and methods of electrochromatography on "lab on a chip" devices are reviewed. Described approaches include open-channel microchip electrochromatography relying on C8, C18 and novel gold nanoparticle (GNP) coating of microchannel wall; packed-channel microchip electrochromatography with new ways of automated loading and unloading of conventional octadecylsilica beads; monolith-based microchip electrochromatography with tailored casting of stationary phase at the specific places of microfluidic network and novel photolitographically fabricated collocated monolithic structures. Specific issues related to the microchip electrochromatography, i.e. importance of high aspect ratio of the microchannels in the open-channel electrochromatography or approaches eliminating the wall effect in the monolith-based electrochromatography, are discussed. Various applications for environmental, pharmacological, genomic and proteomic analysis are described. The operation parameters of reviewed microsystems are summarized in easy-to-read tables.

Original languageEnglish
Pages (from-to)1048-1062
Number of pages15
JournalTalanta
Volume66
Issue number4
DOIs
Publication statusPublished - 2005 May 15

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Metagenomics
Microfluidics
Microchannels
Gold
Proteomics
Nanoparticles
Pharmacology
Equipment and Supplies
Lab-on-a-chip
Microsystems
Unloading
Aspect ratio
Casting
Coatings
octadecylsilica

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

Cite this

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Microchip-based electrochromatography : Designs and applications. / Pumera, Martin.

In: Talanta, Vol. 66, No. 4, 15.05.2005, p. 1048-1062.

Research output: Contribution to journalArticle

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