Abstract
Different techniques and methods of electrochromatography on "lab on a chip" devices are reviewed. Described approaches include open-channel microchip electrochromatography relying on C8, C18 and novel gold nanoparticle (GNP) coating of microchannel wall; packed-channel microchip electrochromatography with new ways of automated loading and unloading of conventional octadecylsilica beads; monolith-based microchip electrochromatography with tailored casting of stationary phase at the specific places of microfluidic network and novel photolitographically fabricated collocated monolithic structures. Specific issues related to the microchip electrochromatography, i.e. importance of high aspect ratio of the microchannels in the open-channel electrochromatography or approaches eliminating the wall effect in the monolith-based electrochromatography, are discussed. Various applications for environmental, pharmacological, genomic and proteomic analysis are described. The operation parameters of reviewed microsystems are summarized in easy-to-read tables.
| Original language | English |
|---|---|
| Pages (from-to) | 1048-1062 |
| Number of pages | 15 |
| Journal | Talanta |
| Volume | 66 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2005 May 15 |
Bibliographical note
Funding Information:This work was supported by NATO Science Program.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry