Microfluidic cell stimulator using bead impact

Young Hun Kim, Tae Jin Kim, Hyung Joon Kim, Min Suk Park, Hyo il Jung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recently many researchers are focused on cell stimulation regarding observation of cells to specific stimulation factors. We introduce new mechanical stimulation method using micro beads without any chemical reagents. CPAE (calf pulmonary artery endothelial cell) were cultured in PDMS (polydimethylsiloxane) microfluidic device. After starvation process, sterilized 10|im glass beads were rolled by only gravitational force for 10 minute. To find optimal stimulation time, 16 devices were made by PDMS and each device was slanted every hour. Results show that cell exposed under micro bead stimulation perform at a higher growth rate than normal conditions and 1 hour stimulation time represents more effective than other stimulation times. This new cell stimulation method will be able to help make artificial organ such as blood vessels in the future.

Original languageEnglish
Title of host publicationBIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices
Pages426-429
Number of pages4
Publication statusPublished - 2009 Jul 21
Event2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009 - Porto, Portugal
Duration: 2009 Jan 142009 Jan 17

Other

Other2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009
CountryPortugal
CityPorto
Period09/1/1409/1/17

Fingerprint

Polydimethylsiloxane
Microfluidics
Artificial organs
Endothelial cells
Blood vessels
Glass

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Kim, Y. H., Kim, T. J., Kim, H. J., Park, M. S., & Jung, H. I. (2009). Microfluidic cell stimulator using bead impact. In BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices (pp. 426-429)
Kim, Young Hun ; Kim, Tae Jin ; Kim, Hyung Joon ; Park, Min Suk ; Jung, Hyo il. / Microfluidic cell stimulator using bead impact. BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices. 2009. pp. 426-429
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Kim, YH, Kim, TJ, Kim, HJ, Park, MS & Jung, HI 2009, Microfluidic cell stimulator using bead impact. in BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices. pp. 426-429, 2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009, Porto, Portugal, 09/1/14.

Microfluidic cell stimulator using bead impact. / Kim, Young Hun; Kim, Tae Jin; Kim, Hyung Joon; Park, Min Suk; Jung, Hyo il.

BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices. 2009. p. 426-429.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Kim YH, Kim TJ, Kim HJ, Park MS, Jung HI. Microfluidic cell stimulator using bead impact. In BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices. 2009. p. 426-429