Abstract
Recently many researchers are focused on cell stimulation regarding observation of cells to specific stimulation factors. We introduce new mechanical stimulation method using micro beads without any chemical reagents. CPAE (calf pulmonary artery endothelial cell) were cultured in PDMS (polydimethylsiloxane) microfluidic device. After starvation process, sterilized 10|im glass beads were rolled by only gravitational force for 10 minute. To find optimal stimulation time, 16 devices were made by PDMS and each device was slanted every hour. Results show that cell exposed under micro bead stimulation perform at a higher growth rate than normal conditions and 1 hour stimulation time represents more effective than other stimulation times. This new cell stimulation method will be able to help make artificial organ such as blood vessels in the future.
| Original language | English |
|---|---|
| Title of host publication | BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices |
| Pages | 426-429 |
| Number of pages | 4 |
| Publication status | Published - 2009 Jul 21 |
| Event | 2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009 - Porto, Portugal Duration: 2009 Jan 14 → 2009 Jan 17 |
Other
| Other | 2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009 |
|---|---|
| Country | Portugal |
| City | Porto |
| Period | 09/1/14 → 09/1/17 |
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All Science Journal Classification (ASJC) codes
- Biomedical Engineering
- Electrical and Electronic Engineering
Cite this
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Microfluidic cell stimulator using bead impact. / Kim, Young Hun; Kim, Tae Jin; Kim, Hyung Joon; Park, Min Suk; Jung, Hyo il.
BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices. 2009. p. 426-429.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Microfluidic cell stimulator using bead impact
AU - Kim, Young Hun
AU - Kim, Tae Jin
AU - Kim, Hyung Joon
AU - Park, Min Suk
AU - Jung, Hyo il
PY - 2009/7/21
Y1 - 2009/7/21
N2 - Recently many researchers are focused on cell stimulation regarding observation of cells to specific stimulation factors. We introduce new mechanical stimulation method using micro beads without any chemical reagents. CPAE (calf pulmonary artery endothelial cell) were cultured in PDMS (polydimethylsiloxane) microfluidic device. After starvation process, sterilized 10|im glass beads were rolled by only gravitational force for 10 minute. To find optimal stimulation time, 16 devices were made by PDMS and each device was slanted every hour. Results show that cell exposed under micro bead stimulation perform at a higher growth rate than normal conditions and 1 hour stimulation time represents more effective than other stimulation times. This new cell stimulation method will be able to help make artificial organ such as blood vessels in the future.
AB - Recently many researchers are focused on cell stimulation regarding observation of cells to specific stimulation factors. We introduce new mechanical stimulation method using micro beads without any chemical reagents. CPAE (calf pulmonary artery endothelial cell) were cultured in PDMS (polydimethylsiloxane) microfluidic device. After starvation process, sterilized 10|im glass beads were rolled by only gravitational force for 10 minute. To find optimal stimulation time, 16 devices were made by PDMS and each device was slanted every hour. Results show that cell exposed under micro bead stimulation perform at a higher growth rate than normal conditions and 1 hour stimulation time represents more effective than other stimulation times. This new cell stimulation method will be able to help make artificial organ such as blood vessels in the future.
UR - http://www.scopus.com/inward/record.url?scp=67650558677&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650558677&partnerID=8YFLogxK
M3 - Conference contribution
SN - 9789898111647
SP - 426
EP - 429
BT - BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices
ER -