Microfluidic chamber arrays for whole-organism high-throughput combinatorial chemical screening based on behavioral responses

Kwanghun Chung, Emily Gong, Jagan Srinivasan, Paul W. Sternberg, Hang Lu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microorganisms are used in genetic research and drug screening because of their low complexity, ease of maintenance, and similar genetics to humans; however, their size makes it difficult for researchers to physically manipulate these microorganisms. This limits the scale on which experiments can be run. We have developed microfluidic technologies to enable high-throughput drug screening. The easy-to-use device allows rapid loading and housing C. elegans in a circular chamber array during drug screening. In addition, chemicals can be precisely delivered to the worms. Our device increases the parallel experimentation number of separate, identifiable microorganisms by ten folds.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages713-715
Number of pages3
Publication statusPublished - 2010 Dec 1
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume2

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

Fingerprint

Microfluidics
Microorganisms
Screening
Throughput
Experiments

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Chung, K., Gong, E., Srinivasan, J., Sternberg, P. W., & Lu, H. (2010). Microfluidic chamber arrays for whole-organism high-throughput combinatorial chemical screening based on behavioral responses. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 713-715). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 2).
Chung, Kwanghun ; Gong, Emily ; Srinivasan, Jagan ; Sternberg, Paul W. ; Lu, Hang. / Microfluidic chamber arrays for whole-organism high-throughput combinatorial chemical screening based on behavioral responses. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. pp. 713-715 (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010).
@inproceedings{2e241b78a1da4a65ba873ef0a56d7b0e,
title = "Microfluidic chamber arrays for whole-organism high-throughput combinatorial chemical screening based on behavioral responses",
abstract = "Microorganisms are used in genetic research and drug screening because of their low complexity, ease of maintenance, and similar genetics to humans; however, their size makes it difficult for researchers to physically manipulate these microorganisms. This limits the scale on which experiments can be run. We have developed microfluidic technologies to enable high-throughput drug screening. The easy-to-use device allows rapid loading and housing C. elegans in a circular chamber array during drug screening. In addition, chemicals can be precisely delivered to the worms. Our device increases the parallel experimentation number of separate, identifiable microorganisms by ten folds.",
author = "Kwanghun Chung and Emily Gong and Jagan Srinivasan and Sternberg, {Paul W.} and Hang Lu",
year = "2010",
month = "12",
day = "1",
language = "English",
isbn = "9781618390622",
series = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
pages = "713--715",
booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",

}

Chung, K, Gong, E, Srinivasan, J, Sternberg, PW & Lu, H 2010, Microfluidic chamber arrays for whole-organism high-throughput combinatorial chemical screening based on behavioral responses. in 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, vol. 2, pp. 713-715, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, Groningen, Netherlands, 10/10/3.

Microfluidic chamber arrays for whole-organism high-throughput combinatorial chemical screening based on behavioral responses. / Chung, Kwanghun; Gong, Emily; Srinivasan, Jagan; Sternberg, Paul W.; Lu, Hang.

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. p. 713-715 (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Microfluidic chamber arrays for whole-organism high-throughput combinatorial chemical screening based on behavioral responses

AU - Chung, Kwanghun

AU - Gong, Emily

AU - Srinivasan, Jagan

AU - Sternberg, Paul W.

AU - Lu, Hang

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Microorganisms are used in genetic research and drug screening because of their low complexity, ease of maintenance, and similar genetics to humans; however, their size makes it difficult for researchers to physically manipulate these microorganisms. This limits the scale on which experiments can be run. We have developed microfluidic technologies to enable high-throughput drug screening. The easy-to-use device allows rapid loading and housing C. elegans in a circular chamber array during drug screening. In addition, chemicals can be precisely delivered to the worms. Our device increases the parallel experimentation number of separate, identifiable microorganisms by ten folds.

AB - Microorganisms are used in genetic research and drug screening because of their low complexity, ease of maintenance, and similar genetics to humans; however, their size makes it difficult for researchers to physically manipulate these microorganisms. This limits the scale on which experiments can be run. We have developed microfluidic technologies to enable high-throughput drug screening. The easy-to-use device allows rapid loading and housing C. elegans in a circular chamber array during drug screening. In addition, chemicals can be precisely delivered to the worms. Our device increases the parallel experimentation number of separate, identifiable microorganisms by ten folds.

UR - http://www.scopus.com/inward/record.url?scp=84884410698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884410698&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84884410698

SN - 9781618390622

T3 - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

SP - 713

EP - 715

BT - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

ER -

Chung K, Gong E, Srinivasan J, Sternberg PW, Lu H. Microfluidic chamber arrays for whole-organism high-throughput combinatorial chemical screening based on behavioral responses. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. p. 713-715. (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010).