Microfluidic detection of circulating tumor cells (CTC) using side filtration-based capture

S. W. Lee, J. Y. Kang, H. I. Jung, K. A. Hyun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Highly sensitive detection of CTCs is difficult because they are extremely rare (i.e. 1∼5 CTC/ 109) in blood. Recently various devices were developed implementing a method of either affinity-based or size-based separation. There are some drawbacks of each method. Antibody-based capturing has low sensitivity if CTCs express less target surface antigen and the size of CTCs overlaps with that of normal blood cells. Hence we utilized a filter on the side of the channel for introducing a deformability in separation principle. The capturing result of this method demonstrated a higher capture rate (95%) and purity (99%) than conventional size-based filtration because easily-deformed CTCs stuck to the holes more tightly than normal blood cells.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages365-367
Number of pages3
ISBN (Print)9781632666246
Publication statusPublished - 2013 Jan 1
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 2013 Oct 272013 Oct 31

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume1

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period13/10/2713/10/31

All Science Journal Classification (ASJC) codes

  • Bioengineering

Fingerprint Dive into the research topics of 'Microfluidic detection of circulating tumor cells (CTC) using side filtration-based capture'. Together they form a unique fingerprint.

  • Cite this

    Lee, S. W., Kang, J. Y., Jung, H. I., & Hyun, K. A. (2013). Microfluidic detection of circulating tumor cells (CTC) using side filtration-based capture. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (pp. 365-367). (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Vol. 1). Chemical and Biological Microsystems Society.