Microfluidic devices to enrich and isolate circulating tumor cells

J. H. Myung, Seungpyo Hong

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Given the potential clinical impact of circulating tumor cells (CTCs) in blood as a clinical biomarker for the diagnosis and prognosis of various cancers, a myriad of detection methods for CTCs have been recently introduced. Among those, a series of microfluidic devices are particularly promising as they uniquely offer micro-scale analytical systems that are highlighted by low consumption of samples and reagents, high flexibility to accommodate other cutting-edge technologies, precise and well-defined flow behaviors, and automation capability, presenting significant advantages over conventional larger scale systems. In this review, we highlight the advantages of microfluidic devices and their potential for translation into CTC detection methods, categorized by miniaturization of bench-top analytical instruments, integration capability with nanotechnologies, and in situ or sequential analysis of captured CTCs. This review provides a comprehensive overview of recent advances in CTC detection achieved through application of microfluidic devices and the challenges that these promising technologies must overcome to be clinically impactful.

Original languageEnglish
Pages (from-to)4500-4511
Number of pages12
JournalLab on a Chip
Volume15
Issue number24
DOIs
Publication statusPublished - 2015 Oct 28

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Lab-On-A-Chip Devices
Circulating Neoplastic Cells
Microfluidics
Tumors
Cells
Technology
Miniaturization
Nanotechnology
Automation
Biomarkers
Large scale systems
Blood

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

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Microfluidic devices to enrich and isolate circulating tumor cells. / Myung, J. H.; Hong, Seungpyo.

In: Lab on a Chip, Vol. 15, No. 24, 28.10.2015, p. 4500-4511.

Research output: Contribution to journalArticle

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