Abstract
Considerable evidence suggests that only a small subset of tumor-initiating cells (TICs) drive tumor formation and metastasis, and those cells have a strong correlation with cell motility. To enrich those TICs, we developed a high-throughput cell migration platform which enables: (1) integration of up to 5,000 migratory channels per device, (2) automatic image collection and analysis, and (3) reliable cell retrieval. Using this platform, we have retrieved highly motile cells for whole transcriptome analysis (mRNA Next Generation Sequencing) and in-vivo validation. Based on sequencing results, we identified the regulating pathways to inhibit cancer cell migration.
| Original language | English |
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| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 49-50 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780979806490 |
| Publication status | Published - 2016 Jan 1 |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13 |
Publication series
| Name | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
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Other
| Other | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|---|
| Country | Ireland |
| City | Dublin |
| Period | 16/10/9 → 16/10/13 |
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All Science Journal Classification (ASJC) codes
- Control and Systems Engineering
Cite this
Chen, Y. C., Xiao, A., Zhang, Z., Luan, Y., Luker, K., Luker, G., & Yoon, E. (2016). Microfluidic high-throughput motility-based cell selection for enriching tumor initiating cells and discovering inhibition pathways of cancer migration. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 49-50). (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016). Chemical and Biological Microsystems Society.