Abstract
The fabrication of a novel microfluidic system, integrated with a set of laser-controlled microactuators on an ePetri on-chip microscopy platform, is presented in this paper. In the fully integrated microfluidic system, a set of novel thermally actuated paraffin-based microactuators, precisely controlled by programmed laser optics, was developed to regulate flow and to provide pumping of liquid solutions without external connections. The microfluidic chip was fabricated on a complementary metal-oxide-semiconductor (CMOS)-imaging sensor chip on an ePetri platform; this configuration provided real-time, wide field-of-view, high-resolution imaging using a sub-pixel sweeping microscopy technique. The system of microactuators, which consisted of microvalves and a micropump, operated well in the microfluidic channel with a focused near-infrared laser beam providing the actuation control. As a demonstration, we used our prototype to assess cell-drug interactions and to monitor cell growth directly within an incubator in real time. The powerful combination of laser-actuated microfluidics and chip-scale microscopy techniques represents a significant step forward in terms of a simple, robust, high-throughput, and highly compact analysis system for biomedical and bioscience applications.
| Original language | English |
|---|---|
| Pages (from-to) | 3781-3789 |
| Number of pages | 9 |
| Journal | Lab on a chip |
| Volume | 14 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Bioengineering
- Biochemistry
- Chemistry(all)
- Biomedical Engineering
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Microfluidic-integrated laser-controlled microactuators with on-chip microscopy imaging functionality. / Jung, Jae Hee; Han, Chao; Lee, Seung Ah; Kim, Jinho; Yang, Changhuei.
In: Lab on a chip, Vol. 14, No. 19, 01.01.2014, p. 3781-3789.Research output: Contribution to journal › Article
TY - JOUR
T1 - Microfluidic-integrated laser-controlled microactuators with on-chip microscopy imaging functionality
AU - Jung, Jae Hee
AU - Han, Chao
AU - Lee, Seung Ah
AU - Kim, Jinho
AU - Yang, Changhuei
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The fabrication of a novel microfluidic system, integrated with a set of laser-controlled microactuators on an ePetri on-chip microscopy platform, is presented in this paper. In the fully integrated microfluidic system, a set of novel thermally actuated paraffin-based microactuators, precisely controlled by programmed laser optics, was developed to regulate flow and to provide pumping of liquid solutions without external connections. The microfluidic chip was fabricated on a complementary metal-oxide-semiconductor (CMOS)-imaging sensor chip on an ePetri platform; this configuration provided real-time, wide field-of-view, high-resolution imaging using a sub-pixel sweeping microscopy technique. The system of microactuators, which consisted of microvalves and a micropump, operated well in the microfluidic channel with a focused near-infrared laser beam providing the actuation control. As a demonstration, we used our prototype to assess cell-drug interactions and to monitor cell growth directly within an incubator in real time. The powerful combination of laser-actuated microfluidics and chip-scale microscopy techniques represents a significant step forward in terms of a simple, robust, high-throughput, and highly compact analysis system for biomedical and bioscience applications.
AB - The fabrication of a novel microfluidic system, integrated with a set of laser-controlled microactuators on an ePetri on-chip microscopy platform, is presented in this paper. In the fully integrated microfluidic system, a set of novel thermally actuated paraffin-based microactuators, precisely controlled by programmed laser optics, was developed to regulate flow and to provide pumping of liquid solutions without external connections. The microfluidic chip was fabricated on a complementary metal-oxide-semiconductor (CMOS)-imaging sensor chip on an ePetri platform; this configuration provided real-time, wide field-of-view, high-resolution imaging using a sub-pixel sweeping microscopy technique. The system of microactuators, which consisted of microvalves and a micropump, operated well in the microfluidic channel with a focused near-infrared laser beam providing the actuation control. As a demonstration, we used our prototype to assess cell-drug interactions and to monitor cell growth directly within an incubator in real time. The powerful combination of laser-actuated microfluidics and chip-scale microscopy techniques represents a significant step forward in terms of a simple, robust, high-throughput, and highly compact analysis system for biomedical and bioscience applications.
UR - http://www.scopus.com/inward/record.url?scp=84906678711&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906678711&partnerID=8YFLogxK
U2 - 10.1039/c4lc00790e
DO - 10.1039/c4lc00790e
M3 - Article
C2 - 25099225
AN - SCOPUS:84906678711
VL - 14
SP - 3781
EP - 3789
JO - Lab on a Chip - Miniaturisation for Chemistry and Biology
JF - Lab on a Chip - Miniaturisation for Chemistry and Biology
SN - 1473-0197
IS - 19
ER -