Microfluidic-integrated laser-controlled microactuators with on-chip microscopy imaging functionality

Jae Hee Jung, Chao Han, Seung Ah Lee, Jinho Kim, Changhuei Yang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The fabrication of a novel microfluidic system, integrated with a set of laser-controlled microactuators on an ePetri on-chip microscopy platform, is presented in this paper. In the fully integrated microfluidic system, a set of novel thermally actuated paraffin-based microactuators, precisely controlled by programmed laser optics, was developed to regulate flow and to provide pumping of liquid solutions without external connections. The microfluidic chip was fabricated on a complementary metal-oxide-semiconductor (CMOS)-imaging sensor chip on an ePetri platform; this configuration provided real-time, wide field-of-view, high-resolution imaging using a sub-pixel sweeping microscopy technique. The system of microactuators, which consisted of microvalves and a micropump, operated well in the microfluidic channel with a focused near-infrared laser beam providing the actuation control. As a demonstration, we used our prototype to assess cell-drug interactions and to monitor cell growth directly within an incubator in real time. The powerful combination of laser-actuated microfluidics and chip-scale microscopy techniques represents a significant step forward in terms of a simple, robust, high-throughput, and highly compact analysis system for biomedical and bioscience applications.

Original languageEnglish
Pages (from-to)3781-3789
Number of pages9
JournalLab on a chip
Volume14
Issue number19
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Microactuators
Microfluidics
Microscopy
Microscopic examination
Lasers
Imaging techniques
Drug interactions
Laser optics
Incubators
Semiconductors
Infrared lasers
Cell growth
Drug Interactions
Cell Communication
Paraffin
Paraffins
Oxides
Laser beams
Demonstrations
Pixels

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Jung, Jae Hee ; Han, Chao ; Lee, Seung Ah ; Kim, Jinho ; Yang, Changhuei. / Microfluidic-integrated laser-controlled microactuators with on-chip microscopy imaging functionality. In: Lab on a chip. 2014 ; Vol. 14, No. 19. pp. 3781-3789.
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Microfluidic-integrated laser-controlled microactuators with on-chip microscopy imaging functionality. / Jung, Jae Hee; Han, Chao; Lee, Seung Ah; Kim, Jinho; Yang, Changhuei.

In: Lab on a chip, Vol. 14, No. 19, 01.01.2014, p. 3781-3789.

Research output: Contribution to journalArticle

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