Microfluidic patterning of P-selectin for cell separation through rolling

Suman Bose, Seungpyo Hong, Robert Langer, Jeffrey M. Karp, Rohit Karnik

Research output: Contribution to conferencePaper

2 Citations (Scopus)

Abstract

We present a new method for label-free separation of cells by rolling on patterned P-selectin receptors. We patterned edges of P-selectin on a substrate using microfluidic channels and flowed a stream of cells and microspheres over the pattern at an angle to the patterns in a microfluidic device. The cells selectively interacted with P-selectin and were deflected from their path out of the flow stream by rolling on the patterned edges. This result provides proof-of-concept of separation and suggests that rolling on patterned receptors may be further developed into a simple, label- free system for separation of cells.

Original languageEnglish
Pages1205-1207
Number of pages3
Publication statusPublished - 2008 Jan 1
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: 2008 Oct 122008 Oct 16

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CountryUnited States
CitySan Diego, CA
Period08/10/1208/10/16

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Bose, S., Hong, S., Langer, R., Karp, J. M., & Karnik, R. (2008). Microfluidic patterning of P-selectin for cell separation through rolling. 1205-1207. Paper presented at 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States.