Micromotors as "motherships": A Concept for the Transport, Delivery, and Enzymatic Release of Molecular Cargo via Nanoparticles

Tomáš Kroupa, Soňa Hermanová, Carmen C. Mayorga-Martinez, Filip Novotný, Zdeněk Sofer, Martin Pumera

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Nano/micromotors based on biodegradable and biocompatible polymers represent a progressively developing group of self-propelled artificial devices capable of delivering biologically active compounds to target sites. The majority of these machines are micron sized, and biologically active compounds are simply attached to their surface. Micron-sized devices cannot enter cells, but they provide rapid velocity, which scales down with the size of the device; nanosized devices can enter cells, but their velocity is negligible. An advanced hierarchical design of the micro/nanodevices is an important tool in the development of functional biocompatible transport systems and their implementation in real in vivo applications. In this work, we demonstrate a "mothership" concept, whereby self-propelled microrobots transport smaller cargo-carrying nanorobots that are released by enzymatic degradation.

Original languageEnglish
Pages (from-to)10618-10624
Number of pages7
JournalLangmuir
Volume35
Issue number32
DOIs
Publication statusPublished - 2019 Aug 13

Bibliographical note

Funding Information:
This work was supported by the project Advanced Functional Nanorobots (reg. no. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR) and from specific university research (MSMT No 21-SVV/2019).

Publisher Copyright:
© 2019 American Chemical Society.

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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