Micro/nanomachines: What is needed for them to become a real force in cancer therapy?

Lucie Reinišová, Soňa Hermanová, Martin Pumera

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)


Conventional drug delivery systems face several issues in medical applications, such as cyto/genotoxicity and off-targeting. These issues are particularly significant for cancer therapeutics because many of the currently used systems are toxic in their free form. Self-propelled autonomous micro/nanomachines offer promising alternative drug delivery systems based on high cargo loading, fast autonomous movement, precise targeting and the on-demand release of therapeutics in vivo. With this unique set of properties, it is not surprising that they are receiving considerable research attention. However, much less is reported about the drawbacks that hinder their systemic in vivo application. In this review, a biomedical perspective is used to assess micro/nanomotor-based anticancer drug delivery systems reported to date. Advantages along with present issues are highlighted and recommendations which need to be considered to develop an effective biocompatible micro/nanomotor-based delivery system for cancer therapy are discussed.

Original languageEnglish
Pages (from-to)6519-6532
Number of pages14
Issue number14
Publication statusPublished - 2019 Apr 14

Bibliographical note

Funding Information:
This work was supported by the project Advanced Functional Nanorobots (Reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR). The authors also gratefully acknowledge the financial support from specific university research (MSMT No 21-SVV/2018).

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

All Science Journal Classification (ASJC) codes

  • Materials Science(all)


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