Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing

Dongxiao Yan; Ahmad Jiman; David Ratze; Shuo Huang; Saman Parizi; Elissa Welle; Zhonghua Ouyang; Paras Patel; Mark J. Kushner; Cynthia Chestek; Tim M. Bruns; Euisik Yoon; John Seymour

doi:10.1109/NER.2019.8717097

Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing

Dongxiao Yan, Ahmad Jiman, David Ratze, Shuo Huang, Saman Parizi, Elissa Welle, Zhonghua Ouyang, Paras Patel, Mark J. Kushner, Cynthia Chestek, Tim M. Bruns, Euisik Yoon, John Seymour

Yonsei Advanced Science Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

Autonomic nerves are typically only hundreds of microns in diameter near their organ targets and these carry all of the sympathetic and parasympathetic control signals. We present a cuff-less microneedle array specifically designed to potentially map small autonomic nerves. The focus of this paper is the design and fabrication of an ultra-miniaturized silicon needle array on a silicone substrate. We demonstrate arrays having 25 to 100 microneedles. Each needle has a 1-micron tip and dual-taper shaft. We demonstrate an ability to control the tip shape, angle, and shaft angle which is important for balancing sharpness and stiffness. These high-density arrays also include a special backside anchor embedded in silicone for stability in the elastic substrate, yet the array freely wraps over a 300-μm nerve. Another critical method presented here is a surgical technique for inserting and securing an array without a cuff (as small as 0.3 mm wide and 1.2 mm long) by photochemical bonding of collagen/Rose Bengal adhesive agents to epineurium. Future work will focus on device functionalization and histological characterization in a rat vagus model.

Original language	English
Title of host publication	9th International IEEE EMBS Conference on Neural Engineering, NER 2019
Publisher	IEEE Computer Society
Pages	827-830
Number of pages	4
ISBN (Electronic)	9781538679210
DOIs	https://doi.org/10.1109/NER.2019.8717097
Publication status	Published - 2019 May 16
Event	9th International IEEE EMBS Conference on Neural Engineering, NER 2019 - San Francisco, United States Duration: 2019 Mar 20 → 2019 Mar 23

Publication series

Name	International IEEE/EMBS Conference on Neural Engineering, NER
Volume	2019-March
ISSN (Print)	1948-3546
ISSN (Electronic)	1948-3554

Conference

Conference	9th International IEEE EMBS Conference on Neural Engineering, NER 2019
Country	United States
City	San Francisco
Period	19/3/20 → 19/3/23

Bibliographical note

Funding Information:
Research supported by NIH SPARC, Award OT2OD024907 D. Yan (yando@umich.edu), D. Ratze, S. Huang, S. Parizi, M. Kushner (mjkush@umich.edu), E. Yoon (esyoon@umich.edu), J. Seymour (seymourj@umich.edu) are with the University of Michigan Department of Electrical Engineering & Computer Science, Ann Arbor, MI, 48109 USA

All Science Journal Classification (ASJC) codes

Artificial Intelligence
Mechanical Engineering

Access to Document

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Yan, D., Jiman, A., Ratze, D., Huang, S., Parizi, S., Welle, E., Ouyang, Z., Patel, P., Kushner, M. J., Chestek, C., Bruns, T. M., Yoon, E., & Seymour, J. (2019). Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing. In 9th International IEEE EMBS Conference on Neural Engineering, NER 2019 (pp. 827-830). [8717097] (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2019-March). IEEE Computer Society. https://doi.org/10.1109/NER.2019.8717097

Yan, Dongxiao ; Jiman, Ahmad ; Ratze, David ; Huang, Shuo ; Parizi, Saman ; Welle, Elissa ; Ouyang, Zhonghua ; Patel, Paras ; Kushner, Mark J. ; Chestek, Cynthia ; Bruns, Tim M. ; Yoon, Euisik ; Seymour, John. / Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing. 9th International IEEE EMBS Conference on Neural Engineering, NER 2019. IEEE Computer Society, 2019. pp. 827-830 (International IEEE/EMBS Conference on Neural Engineering, NER).

@inproceedings{03ecbdd589a542038f6501e224f0db85,

title = "Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing",

abstract = "Autonomic nerves are typically only hundreds of microns in diameter near their organ targets and these carry all of the sympathetic and parasympathetic control signals. We present a cuff-less microneedle array specifically designed to potentially map small autonomic nerves. The focus of this paper is the design and fabrication of an ultra-miniaturized silicon needle array on a silicone substrate. We demonstrate arrays having 25 to 100 microneedles. Each needle has a 1-micron tip and dual-taper shaft. We demonstrate an ability to control the tip shape, angle, and shaft angle which is important for balancing sharpness and stiffness. These high-density arrays also include a special backside anchor embedded in silicone for stability in the elastic substrate, yet the array freely wraps over a 300-μm nerve. Another critical method presented here is a surgical technique for inserting and securing an array without a cuff (as small as 0.3 mm wide and 1.2 mm long) by photochemical bonding of collagen/Rose Bengal adhesive agents to epineurium. Future work will focus on device functionalization and histological characterization in a rat vagus model.",

author = "Dongxiao Yan and Ahmad Jiman and David Ratze and Shuo Huang and Saman Parizi and Elissa Welle and Zhonghua Ouyang and Paras Patel and Kushner, {Mark J.} and Cynthia Chestek and Bruns, {Tim M.} and Euisik Yoon and John Seymour",

note = "Funding Information: Research supported by NIH SPARC, Award OT2OD024907 D. Yan (yando@umich.edu), D. Ratze, S. Huang, S. Parizi, M. Kushner (mjkush@umich.edu), E. Yoon (esyoon@umich.edu), J. Seymour (seymourj@umich.edu) are with the University of Michigan Department of Electrical Engineering & Computer Science, Ann Arbor, MI, 48109 USA; 9th International IEEE EMBS Conference on Neural Engineering, NER 2019 ; Conference date: 20-03-2019 Through 23-03-2019",

year = "2019",

month = may,

day = "16",

doi = "10.1109/NER.2019.8717097",

language = "English",

series = "International IEEE/EMBS Conference on Neural Engineering, NER",

publisher = "IEEE Computer Society",

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Yan, D, Jiman, A, Ratze, D, Huang, S, Parizi, S, Welle, E, Ouyang, Z, Patel, P, Kushner, MJ, Chestek, C, Bruns, TM, Yoon, E & Seymour, J 2019, Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing. in 9th International IEEE EMBS Conference on Neural Engineering, NER 2019., 8717097, International IEEE/EMBS Conference on Neural Engineering, NER, vol. 2019-March, IEEE Computer Society, pp. 827-830, 9th International IEEE EMBS Conference on Neural Engineering, NER 2019, San Francisco, United States, 19/3/20. https://doi.org/10.1109/NER.2019.8717097

Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing. / Yan, Dongxiao; Jiman, Ahmad; Ratze, David; Huang, Shuo; Parizi, Saman; Welle, Elissa; Ouyang, Zhonghua; Patel, Paras; Kushner, Mark J.; Chestek, Cynthia; Bruns, Tim M.; Yoon, Euisik; Seymour, John.

9th International IEEE EMBS Conference on Neural Engineering, NER 2019. IEEE Computer Society, 2019. p. 827-830 8717097 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2019-March).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing

AU - Yan, Dongxiao

AU - Jiman, Ahmad

AU - Ratze, David

AU - Huang, Shuo

AU - Parizi, Saman

AU - Welle, Elissa

AU - Ouyang, Zhonghua

AU - Patel, Paras

AU - Kushner, Mark J.

AU - Chestek, Cynthia

AU - Bruns, Tim M.

AU - Yoon, Euisik

AU - Seymour, John

N1 - Funding Information: Research supported by NIH SPARC, Award OT2OD024907 D. Yan (yando@umich.edu), D. Ratze, S. Huang, S. Parizi, M. Kushner (mjkush@umich.edu), E. Yoon (esyoon@umich.edu), J. Seymour (seymourj@umich.edu) are with the University of Michigan Department of Electrical Engineering & Computer Science, Ann Arbor, MI, 48109 USA

PY - 2019/5/16

Y1 - 2019/5/16

N2 - Autonomic nerves are typically only hundreds of microns in diameter near their organ targets and these carry all of the sympathetic and parasympathetic control signals. We present a cuff-less microneedle array specifically designed to potentially map small autonomic nerves. The focus of this paper is the design and fabrication of an ultra-miniaturized silicon needle array on a silicone substrate. We demonstrate arrays having 25 to 100 microneedles. Each needle has a 1-micron tip and dual-taper shaft. We demonstrate an ability to control the tip shape, angle, and shaft angle which is important for balancing sharpness and stiffness. These high-density arrays also include a special backside anchor embedded in silicone for stability in the elastic substrate, yet the array freely wraps over a 300-μm nerve. Another critical method presented here is a surgical technique for inserting and securing an array without a cuff (as small as 0.3 mm wide and 1.2 mm long) by photochemical bonding of collagen/Rose Bengal adhesive agents to epineurium. Future work will focus on device functionalization and histological characterization in a rat vagus model.

AB - Autonomic nerves are typically only hundreds of microns in diameter near their organ targets and these carry all of the sympathetic and parasympathetic control signals. We present a cuff-less microneedle array specifically designed to potentially map small autonomic nerves. The focus of this paper is the design and fabrication of an ultra-miniaturized silicon needle array on a silicone substrate. We demonstrate arrays having 25 to 100 microneedles. Each needle has a 1-micron tip and dual-taper shaft. We demonstrate an ability to control the tip shape, angle, and shaft angle which is important for balancing sharpness and stiffness. These high-density arrays also include a special backside anchor embedded in silicone for stability in the elastic substrate, yet the array freely wraps over a 300-μm nerve. Another critical method presented here is a surgical technique for inserting and securing an array without a cuff (as small as 0.3 mm wide and 1.2 mm long) by photochemical bonding of collagen/Rose Bengal adhesive agents to epineurium. Future work will focus on device functionalization and histological characterization in a rat vagus model.

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M3 - Conference contribution

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Yan D, Jiman A, Ratze D, Huang S, Parizi S, Welle E et al. Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing. In 9th International IEEE EMBS Conference on Neural Engineering, NER 2019. IEEE Computer Society. 2019. p. 827-830. 8717097. (International IEEE/EMBS Conference on Neural Engineering, NER). https://doi.org/10.1109/NER.2019.8717097