Abstract
Autonomic nerves are typically only hundreds of microns in diameter near their organ targets and these carry all of the sympathetic and parasympathetic control signals. We present a cuff-less microneedle array specifically designed to potentially map small autonomic nerves. The focus of this paper is the design and fabrication of an ultra-miniaturized silicon needle array on a silicone substrate. We demonstrate arrays having 25 to 100 microneedles. Each needle has a 1-micron tip and dual-taper shaft. We demonstrate an ability to control the tip shape, angle, and shaft angle which is important for balancing sharpness and stiffness. These high-density arrays also include a special backside anchor embedded in silicone for stability in the elastic substrate, yet the array freely wraps over a 300-μm nerve. Another critical method presented here is a surgical technique for inserting and securing an array without a cuff (as small as 0.3 mm wide and 1.2 mm long) by photochemical bonding of collagen/Rose Bengal adhesive agents to epineurium. Future work will focus on device functionalization and histological characterization in a rat vagus model.
| Original language | English |
|---|---|
| Title of host publication | 9th International IEEE EMBS Conference on Neural Engineering, NER 2019 |
| Publisher | IEEE Computer Society |
| Pages | 827-830 |
| Number of pages | 4 |
| ISBN (Electronic) | 9781538679210 |
| DOIs | |
| Publication status | Published - 2019 May 16 |
| Event | 9th International IEEE EMBS Conference on Neural Engineering, NER 2019 - San Francisco, United States Duration: 2019 Mar 20 → 2019 Mar 23 |
Publication series
| Name | International IEEE/EMBS Conference on Neural Engineering, NER |
|---|---|
| Volume | 2019-March |
| ISSN (Print) | 1948-3546 |
| ISSN (Electronic) | 1948-3554 |
Conference
| Conference | 9th International IEEE EMBS Conference on Neural Engineering, NER 2019 |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 19/3/20 → 19/3/23 |
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All Science Journal Classification (ASJC) codes
- Artificial Intelligence
- Mechanical Engineering
Cite this
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Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing. / Yan, Dongxiao; Jiman, Ahmad; Ratze, David; Huang, Shuo; Parizi, Saman; Welle, Elissa; Ouyang, Zhonghua; Patel, Paras; Kushner, Mark J.; Chestek, Cynthia; Bruns, Tim M.; Yoon, Euisik; Seymour, John.
9th International IEEE EMBS Conference on Neural Engineering, NER 2019. IEEE Computer Society, 2019. p. 827-830 8717097 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2019-March).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing
AU - Yan, Dongxiao
AU - Jiman, Ahmad
AU - Ratze, David
AU - Huang, Shuo
AU - Parizi, Saman
AU - Welle, Elissa
AU - Ouyang, Zhonghua
AU - Patel, Paras
AU - Kushner, Mark J.
AU - Chestek, Cynthia
AU - Bruns, Tim M.
AU - Yoon, Euisik
AU - Seymour, John
PY - 2019/5/16
Y1 - 2019/5/16
N2 - Autonomic nerves are typically only hundreds of microns in diameter near their organ targets and these carry all of the sympathetic and parasympathetic control signals. We present a cuff-less microneedle array specifically designed to potentially map small autonomic nerves. The focus of this paper is the design and fabrication of an ultra-miniaturized silicon needle array on a silicone substrate. We demonstrate arrays having 25 to 100 microneedles. Each needle has a 1-micron tip and dual-taper shaft. We demonstrate an ability to control the tip shape, angle, and shaft angle which is important for balancing sharpness and stiffness. These high-density arrays also include a special backside anchor embedded in silicone for stability in the elastic substrate, yet the array freely wraps over a 300-μm nerve. Another critical method presented here is a surgical technique for inserting and securing an array without a cuff (as small as 0.3 mm wide and 1.2 mm long) by photochemical bonding of collagen/Rose Bengal adhesive agents to epineurium. Future work will focus on device functionalization and histological characterization in a rat vagus model.
AB - Autonomic nerves are typically only hundreds of microns in diameter near their organ targets and these carry all of the sympathetic and parasympathetic control signals. We present a cuff-less microneedle array specifically designed to potentially map small autonomic nerves. The focus of this paper is the design and fabrication of an ultra-miniaturized silicon needle array on a silicone substrate. We demonstrate arrays having 25 to 100 microneedles. Each needle has a 1-micron tip and dual-taper shaft. We demonstrate an ability to control the tip shape, angle, and shaft angle which is important for balancing sharpness and stiffness. These high-density arrays also include a special backside anchor embedded in silicone for stability in the elastic substrate, yet the array freely wraps over a 300-μm nerve. Another critical method presented here is a surgical technique for inserting and securing an array without a cuff (as small as 0.3 mm wide and 1.2 mm long) by photochemical bonding of collagen/Rose Bengal adhesive agents to epineurium. Future work will focus on device functionalization and histological characterization in a rat vagus model.
UR - http://www.scopus.com/inward/record.url?scp=85066766184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066766184&partnerID=8YFLogxK
U2 - 10.1109/NER.2019.8717097
DO - 10.1109/NER.2019.8717097
M3 - Conference contribution
AN - SCOPUS:85066766184
T3 - International IEEE/EMBS Conference on Neural Engineering, NER
SP - 827
EP - 830
BT - 9th International IEEE EMBS Conference on Neural Engineering, NER 2019
PB - IEEE Computer Society
ER -