Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing

Dongxiao Yan, Ahmad Jiman, David Ratze, Shuo Huang, Saman Parizi, Elissa Welle, Zhonghua Ouyang, Paras Patel, Mark J. Kushner, Cynthia Chestek, Tim M. Bruns, Euisik Yoon, John Seymour

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Autonomic nerves are typically only hundreds of microns in diameter near their organ targets and these carry all of the sympathetic and parasympathetic control signals. We present a cuff-less microneedle array specifically designed to potentially map small autonomic nerves. The focus of this paper is the design and fabrication of an ultra-miniaturized silicon needle array on a silicone substrate. We demonstrate arrays having 25 to 100 microneedles. Each needle has a 1-micron tip and dual-taper shaft. We demonstrate an ability to control the tip shape, angle, and shaft angle which is important for balancing sharpness and stiffness. These high-density arrays also include a special backside anchor embedded in silicone for stability in the elastic substrate, yet the array freely wraps over a 300-μm nerve. Another critical method presented here is a surgical technique for inserting and securing an array without a cuff (as small as 0.3 mm wide and 1.2 mm long) by photochemical bonding of collagen/Rose Bengal adhesive agents to epineurium. Future work will focus on device functionalization and histological characterization in a rat vagus model.

Original languageEnglish
Title of host publication9th International IEEE EMBS Conference on Neural Engineering, NER 2019
PublisherIEEE Computer Society
Pages827-830
Number of pages4
ISBN (Electronic)9781538679210
DOIs
Publication statusPublished - 2019 May 16
Event9th International IEEE EMBS Conference on Neural Engineering, NER 2019 - San Francisco, United States
Duration: 2019 Mar 202019 Mar 23

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
Volume2019-March
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Conference

Conference9th International IEEE EMBS Conference on Neural Engineering, NER 2019
CountryUnited States
CitySan Francisco
Period19/3/2019/3/23

Fingerprint

Silicones
Needles
Substrates
Anchors
Collagen
Rats
Adhesives
Stiffness
Fabrication
Silicon
Axons

All Science Journal Classification (ASJC) codes

  • Artificial Intelligence
  • Mechanical Engineering

Cite this

Yan, D., Jiman, A., Ratze, D., Huang, S., Parizi, S., Welle, E., ... Seymour, J. (2019). Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing. In 9th International IEEE EMBS Conference on Neural Engineering, NER 2019 (pp. 827-830). [8717097] (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2019-March). IEEE Computer Society. https://doi.org/10.1109/NER.2019.8717097
Yan, Dongxiao ; Jiman, Ahmad ; Ratze, David ; Huang, Shuo ; Parizi, Saman ; Welle, Elissa ; Ouyang, Zhonghua ; Patel, Paras ; Kushner, Mark J. ; Chestek, Cynthia ; Bruns, Tim M. ; Yoon, Euisik ; Seymour, John. / Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing. 9th International IEEE EMBS Conference on Neural Engineering, NER 2019. IEEE Computer Society, 2019. pp. 827-830 (International IEEE/EMBS Conference on Neural Engineering, NER).
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Yan, D, Jiman, A, Ratze, D, Huang, S, Parizi, S, Welle, E, Ouyang, Z, Patel, P, Kushner, MJ, Chestek, C, Bruns, TM, Yoon, E & Seymour, J 2019, Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing. in 9th International IEEE EMBS Conference on Neural Engineering, NER 2019., 8717097, International IEEE/EMBS Conference on Neural Engineering, NER, vol. 2019-March, IEEE Computer Society, pp. 827-830, 9th International IEEE EMBS Conference on Neural Engineering, NER 2019, San Francisco, United States, 19/3/20. https://doi.org/10.1109/NER.2019.8717097

Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing. / Yan, Dongxiao; Jiman, Ahmad; Ratze, David; Huang, Shuo; Parizi, Saman; Welle, Elissa; Ouyang, Zhonghua; Patel, Paras; Kushner, Mark J.; Chestek, Cynthia; Bruns, Tim M.; Yoon, Euisik; Seymour, John.

9th International IEEE EMBS Conference on Neural Engineering, NER 2019. IEEE Computer Society, 2019. p. 827-830 8717097 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2019-March).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Yan D, Jiman A, Ratze D, Huang S, Parizi S, Welle E et al. Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing. In 9th International IEEE EMBS Conference on Neural Engineering, NER 2019. IEEE Computer Society. 2019. p. 827-830. 8717097. (International IEEE/EMBS Conference on Neural Engineering, NER). https://doi.org/10.1109/NER.2019.8717097