Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance

Dae Hyun Kim; Jung Bok Lee; Mi Lan Kang; Ji Hwan Park; Jin You; Seongmi Yu; Ju Young Park; Seung Bae Ryu; Gyeung Mi Seon; Jeong Kee Yoon; Mi Hee Lee; Young Min Shin; Ki Dong Park; Jong Chul Park; Woo Soon Jang; Won Shik Kim; Hak Joon Sung

doi:10.1021/acsbiomaterials.8b01097

Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance

Dae Hyun Kim, Jung Bok Lee, Mi Lan Kang, Ji Hwan Park, Jin You, Seongmi Yu, Ju Young Park, Seung Bae Ryu, Gyeung Mi Seon, Jeong Kee Yoon, Mi Hee Lee, Young Min Shin, Ki Dong Park, Jong Chul Park, Woo Soon Jang, Won Shik Kim, Hak Joon Sung

Department of Medical Engineering

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

To make up for the shortcomings of the suture-based approach and current coupler devices including long suturing time, exhaustive training, additional mechanical setting, and narrow working windows for size and type of diverse vessel types, a new, suture-free microneedle coupler was developed in this study. The needle shape for improved anastomosis performance and the condition for antithrombotic surface immobilization were determined. In particular, the polymer materials help to maintain healthy phenotypes of main vascular cell types. The performance in rabbit and porcine models of end-to-end vascular anastomosis indicate that this device can serve as a potent alternative to the current approaches.

Original language	English
Pages (from-to)	3848-3853
Number of pages	6
Journal	ACS Biomaterials Science and Engineering
Volume	4
Issue number	11
DOIs	https://doi.org/10.1021/acsbiomaterials.8b01097
Publication status	Published - 2018 Nov 12

Bibliographical note

Funding Information:
This study was financially supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2016M3A9E9941743 and 2017M3A9E9087117).

Publisher Copyright:
© Copyright 2018 American Chemical Society.

All Science Journal Classification (ASJC) codes

Biomaterials
Biomedical Engineering

Access to Document

10.1021/acsbiomaterials.8b01097

Cite this

Kim, D. H., Lee, J. B., Kang, M. L., Park, J. H., You, J., Yu, S., Park, J. Y., Ryu, S. B., Seon, G. M., Yoon, J. K., Lee, M. H., Shin, Y. M., Park, K. D., Park, J. C., Jang, W. S., Kim, W. S., & Sung, H. J. (2018). Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance. ACS Biomaterials Science and Engineering, 4(11), 3848-3853. https://doi.org/10.1021/acsbiomaterials.8b01097

@article{e39c1c16f5f1481384345cabf0df04c4,

title = "Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance",

abstract = "To make up for the shortcomings of the suture-based approach and current coupler devices including long suturing time, exhaustive training, additional mechanical setting, and narrow working windows for size and type of diverse vessel types, a new, suture-free microneedle coupler was developed in this study. The needle shape for improved anastomosis performance and the condition for antithrombotic surface immobilization were determined. In particular, the polymer materials help to maintain healthy phenotypes of main vascular cell types. The performance in rabbit and porcine models of end-to-end vascular anastomosis indicate that this device can serve as a potent alternative to the current approaches.",

author = "Kim, {Dae Hyun} and Lee, {Jung Bok} and Kang, {Mi Lan} and Park, {Ji Hwan} and Jin You and Seongmi Yu and Park, {Ju Young} and Ryu, {Seung Bae} and Seon, {Gyeung Mi} and Yoon, {Jeong Kee} and Lee, {Mi Hee} and Shin, {Young Min} and Park, {Ki Dong} and Park, {Jong Chul} and Jang, {Woo Soon} and Kim, {Won Shik} and Sung, {Hak Joon}",

note = "Funding Information: This study was financially supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2016M3A9E9941743 and 2017M3A9E9087117). Publisher Copyright: {\textcopyright} Copyright 2018 American Chemical Society.",

year = "2018",

month = nov,

day = "12",

doi = "10.1021/acsbiomaterials.8b01097",

language = "English",

volume = "4",

pages = "3848--3853",

journal = "ACS Biomaterials Science and Engineering",

issn = "2373-9878",

publisher = "American Chemical Society",

number = "11",

}

Kim, DH, Lee, JB, Kang, ML, Park, JH, You, J, Yu, S, Park, JY, Ryu, SB, Seon, GM, Yoon, JK, Lee, MH, Shin, YM, Park, KD, Park, JC, Jang, WS, Kim, WS & Sung, HJ 2018, 'Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance', ACS Biomaterials Science and Engineering, vol. 4, no. 11, pp. 3848-3853. https://doi.org/10.1021/acsbiomaterials.8b01097

TY - JOUR

T1 - Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance

AU - Kim, Dae Hyun

AU - Lee, Jung Bok

AU - Kang, Mi Lan

AU - Park, Ji Hwan

AU - You, Jin

AU - Yu, Seongmi

AU - Park, Ju Young

AU - Ryu, Seung Bae

AU - Seon, Gyeung Mi

AU - Yoon, Jeong Kee

AU - Lee, Mi Hee

AU - Shin, Young Min

AU - Park, Ki Dong

AU - Park, Jong Chul

AU - Jang, Woo Soon

AU - Kim, Won Shik

AU - Sung, Hak Joon

N1 - Funding Information: This study was financially supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2016M3A9E9941743 and 2017M3A9E9087117). Publisher Copyright: © Copyright 2018 American Chemical Society.

PY - 2018/11/12

Y1 - 2018/11/12

N2 - To make up for the shortcomings of the suture-based approach and current coupler devices including long suturing time, exhaustive training, additional mechanical setting, and narrow working windows for size and type of diverse vessel types, a new, suture-free microneedle coupler was developed in this study. The needle shape for improved anastomosis performance and the condition for antithrombotic surface immobilization were determined. In particular, the polymer materials help to maintain healthy phenotypes of main vascular cell types. The performance in rabbit and porcine models of end-to-end vascular anastomosis indicate that this device can serve as a potent alternative to the current approaches.

AB - To make up for the shortcomings of the suture-based approach and current coupler devices including long suturing time, exhaustive training, additional mechanical setting, and narrow working windows for size and type of diverse vessel types, a new, suture-free microneedle coupler was developed in this study. The needle shape for improved anastomosis performance and the condition for antithrombotic surface immobilization were determined. In particular, the polymer materials help to maintain healthy phenotypes of main vascular cell types. The performance in rabbit and porcine models of end-to-end vascular anastomosis indicate that this device can serve as a potent alternative to the current approaches.

UR - http://www.scopus.com/inward/record.url?scp=85056269378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056269378&partnerID=8YFLogxK

U2 - 10.1021/acsbiomaterials.8b01097

DO - 10.1021/acsbiomaterials.8b01097

M3 - Article

AN - SCOPUS:85056269378

SN - 2373-9878

VL - 4

SP - 3848

EP - 3853

JO - ACS Biomaterials Science and Engineering

JF - ACS Biomaterials Science and Engineering

IS - 11

ER -

Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this