Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance

Dae Hyun Kim, Jung Bok Lee, Mi Lan Kang, Ji Hwan Park, Jin You, Seongmi Yu, Ju Young Park, Seung Bae Ryu, Gyeung Mi Seon, Jeong Kee Yoon, Mi Hee Lee, Young Min Shin, Ki Dong Park, Jong Chul Park, Woo Soon Jang, Won Shik Kim, Hak Joon Sung

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


To make up for the shortcomings of the suture-based approach and current coupler devices including long suturing time, exhaustive training, additional mechanical setting, and narrow working windows for size and type of diverse vessel types, a new, suture-free microneedle coupler was developed in this study. The needle shape for improved anastomosis performance and the condition for antithrombotic surface immobilization were determined. In particular, the polymer materials help to maintain healthy phenotypes of main vascular cell types. The performance in rabbit and porcine models of end-to-end vascular anastomosis indicate that this device can serve as a potent alternative to the current approaches.

Original languageEnglish
Pages (from-to)3848-3853
Number of pages6
JournalACS Biomaterials Science and Engineering
Issue number11
Publication statusPublished - 2018 Nov 12

Bibliographical note

Funding Information:
This study was financially supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2016M3A9E9941743 and 2017M3A9E9087117).

Publisher Copyright:
© Copyright 2018 American Chemical Society.

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering


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