Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance

Dae Hyun Kim, Jung Bok Lee, Mi Lan Kang, Ji Hwan Park, Jin You, Seongmi Yu, Ju Young Park, Seung Bae Ryu, Gyeung Mi Seon, Jeong Kee Yoon, Mi Hee Lee, Young Min Shin, Ki Dong Park, Jong Chul Park, Woo Soon Jang, Won Shik Kim, Hak Joon Sung

Research output: Contribution to journalArticle

Abstract

To make up for the shortcomings of the suture-based approach and current coupler devices including long suturing time, exhaustive training, additional mechanical setting, and narrow working windows for size and type of diverse vessel types, a new, suture-free microneedle coupler was developed in this study. The needle shape for improved anastomosis performance and the condition for antithrombotic surface immobilization were determined. In particular, the polymer materials help to maintain healthy phenotypes of main vascular cell types. The performance in rabbit and porcine models of end-to-end vascular anastomosis indicate that this device can serve as a potent alternative to the current approaches.

Original languageEnglish
Pages (from-to)3848-3853
Number of pages6
JournalACS Biomaterials Science and Engineering
Volume4
Issue number11
DOIs
Publication statusPublished - 2018 Nov 12

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Needles
Heparin
Polymers

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Kim, Dae Hyun ; Lee, Jung Bok ; Kang, Mi Lan ; Park, Ji Hwan ; You, Jin ; Yu, Seongmi ; Park, Ju Young ; Ryu, Seung Bae ; Seon, Gyeung Mi ; Yoon, Jeong Kee ; Lee, Mi Hee ; Shin, Young Min ; Park, Ki Dong ; Park, Jong Chul ; Jang, Woo Soon ; Kim, Won Shik ; Sung, Hak Joon. / Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance. In: ACS Biomaterials Science and Engineering. 2018 ; Vol. 4, No. 11. pp. 3848-3853.
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Kim, DH, Lee, JB, Kang, ML, Park, JH, You, J, Yu, S, Park, JY, Ryu, SB, Seon, GM, Yoon, JK, Lee, MH, Shin, YM, Park, KD, Park, JC, Jang, WS, Kim, WS & Sung, HJ 2018, 'Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance', ACS Biomaterials Science and Engineering, vol. 4, no. 11, pp. 3848-3853. https://doi.org/10.1021/acsbiomaterials.8b01097

Microneedle Vascular Couplers with Heparin-Immobilized Surface Improve Suture-Free Anastomosis Performance. / Kim, Dae Hyun; Lee, Jung Bok; Kang, Mi Lan; Park, Ji Hwan; You, Jin; Yu, Seongmi; Park, Ju Young; Ryu, Seung Bae; Seon, Gyeung Mi; Yoon, Jeong Kee; Lee, Mi Hee; Shin, Young Min; Park, Ki Dong; Park, Jong Chul; Jang, Woo Soon; Kim, Won Shik; Sung, Hak Joon.

In: ACS Biomaterials Science and Engineering, Vol. 4, No. 11, 12.11.2018, p. 3848-3853.

Research output: Contribution to journalArticle

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AU - Lee, Jung Bok

AU - Kang, Mi Lan

AU - Park, Ji Hwan

AU - You, Jin

AU - Yu, Seongmi

AU - Park, Ju Young

AU - Ryu, Seung Bae

AU - Seon, Gyeung Mi

AU - Yoon, Jeong Kee

AU - Lee, Mi Hee

AU - Shin, Young Min

AU - Park, Ki Dong

AU - Park, Jong Chul

AU - Jang, Woo Soon

AU - Kim, Won Shik

AU - Sung, Hak Joon

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