MicroRNA-944 overexpression is a biomarker for poor prognosis of advanced cervical cancer

Sunyoung Park; Jungho Kim; Kiyoon Eom; Sehee Oh; Sunghyun Kim; Geehyuk Kim; Sungwoo Ahn; Kwang Hwa Park; Dawn Chung; Hyeyoung Lee

doi:10.1186/s12885-019-5620-6

MicroRNA-944 overexpression is a biomarker for poor prognosis of advanced cervical cancer

Sunyoung Park, Jungho Kim, Kiyoon Eom, Sehee Oh, Sunghyun Kim, Geehyuk Kim, Sungwoo Ahn, Kwang Hwa Park, Dawn Chung, Hyeyoung Lee

Biomedical Laboratory Science

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Background: One-third of cervical cancer patients are still diagnosed at advanced stages. The five-year survival rate is decreased in about 50% of advanced stage cervical cancer patients worldwide, and the clinical outcomes are remarkably varied and difficult to predict. One of the miRNAs known to be associated with cancer tumorigenesis is miR-944. However, the prognostic value of miR-944 in cervical cancer has not been fully investigated. The aim of this study was to analyze clinical significance and prognostic value of miR-944 in cervical cancer. Methods: The expression levels of miR-944 were detected using quantitative reverse transcription polymerase chain reaction in five types of cervical cancer cell lines and 116 formalin-fixed paraffin-embedded (FFPE) cervical tissues. The association between the expression levels of miR-944 and prognostic value was analyzed using the Kaplan-Meier analysis and Cox proportional hazards model. Results: The expression levels of miR-944 in cervical cancer tissues were significantly higher compared with those in normal tissues (P < 0.0001). Moreover, the expression levels of miR-944 in cervical cancer cell lines and FFPE tissues with human papillomavirus (HPV) infection were significantly higher compared to those without HPV infection (P < 0.01 and P = 0.02). High miR-944 expression was also markedly associated with bulky tumor size (P = 0.026), advanced International Federation of Gynecology and Obstetrics (FIGO) stage (P = 0.042), and lymph node metastasis (P = 0.030). In particular, high miR-944 expression group showed shorter overall survival than the low miR-944 expression group in the advanced FIGO stage (84.4% vs. 44.4%, HR = 4.0, and P = 0.01). Conclusions: These results suggest that miR-944 may be used as a novel biomarker for improving prognosis and as a potential therapeutic target.

Original language	English
Article number	419
Journal	BMC cancer
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12885-019-5620-6
Publication status	Published - 2019 May 6

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (grant no. 2015R1A2A2A04004455). The funding bodies had no role in the study design, data collection, analysis, interpretation of data, and writing of the manuscript.

Publisher Copyright:
© 2019 The Author(s).

All Science Journal Classification (ASJC) codes

Oncology
Genetics
Cancer Research

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10.1186/s12885-019-5620-6

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@article{fcb73f00474247b680ba241d3918caf2,

title = "MicroRNA-944 overexpression is a biomarker for poor prognosis of advanced cervical cancer",

abstract = "Background: One-third of cervical cancer patients are still diagnosed at advanced stages. The five-year survival rate is decreased in about 50% of advanced stage cervical cancer patients worldwide, and the clinical outcomes are remarkably varied and difficult to predict. One of the miRNAs known to be associated with cancer tumorigenesis is miR-944. However, the prognostic value of miR-944 in cervical cancer has not been fully investigated. The aim of this study was to analyze clinical significance and prognostic value of miR-944 in cervical cancer. Methods: The expression levels of miR-944 were detected using quantitative reverse transcription polymerase chain reaction in five types of cervical cancer cell lines and 116 formalin-fixed paraffin-embedded (FFPE) cervical tissues. The association between the expression levels of miR-944 and prognostic value was analyzed using the Kaplan-Meier analysis and Cox proportional hazards model. Results: The expression levels of miR-944 in cervical cancer tissues were significantly higher compared with those in normal tissues (P < 0.0001). Moreover, the expression levels of miR-944 in cervical cancer cell lines and FFPE tissues with human papillomavirus (HPV) infection were significantly higher compared to those without HPV infection (P < 0.01 and P = 0.02). High miR-944 expression was also markedly associated with bulky tumor size (P = 0.026), advanced International Federation of Gynecology and Obstetrics (FIGO) stage (P = 0.042), and lymph node metastasis (P = 0.030). In particular, high miR-944 expression group showed shorter overall survival than the low miR-944 expression group in the advanced FIGO stage (84.4% vs. 44.4%, HR = 4.0, and P = 0.01). Conclusions: These results suggest that miR-944 may be used as a novel biomarker for improving prognosis and as a potential therapeutic target.",

author = "Sunyoung Park and Jungho Kim and Kiyoon Eom and Sehee Oh and Sunghyun Kim and Geehyuk Kim and Sungwoo Ahn and Park, {Kwang Hwa} and Dawn Chung and Hyeyoung Lee",

note = "Funding Information: This work was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (grant no. 2015R1A2A2A04004455). The funding bodies had no role in the study design, data collection, analysis, interpretation of data, and writing of the manuscript. Publisher Copyright: {\textcopyright} 2019 The Author(s).",

year = "2019",

month = may,

day = "6",

doi = "10.1186/s12885-019-5620-6",

language = "English",

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T1 - MicroRNA-944 overexpression is a biomarker for poor prognosis of advanced cervical cancer

AU - Park, Sunyoung

AU - Kim, Jungho

AU - Eom, Kiyoon

AU - Oh, Sehee

AU - Kim, Sunghyun

AU - Kim, Geehyuk

AU - Ahn, Sungwoo

AU - Park, Kwang Hwa

AU - Chung, Dawn

AU - Lee, Hyeyoung

N1 - Funding Information: This work was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (grant no. 2015R1A2A2A04004455). The funding bodies had no role in the study design, data collection, analysis, interpretation of data, and writing of the manuscript. Publisher Copyright: © 2019 The Author(s).

PY - 2019/5/6

Y1 - 2019/5/6

N2 - Background: One-third of cervical cancer patients are still diagnosed at advanced stages. The five-year survival rate is decreased in about 50% of advanced stage cervical cancer patients worldwide, and the clinical outcomes are remarkably varied and difficult to predict. One of the miRNAs known to be associated with cancer tumorigenesis is miR-944. However, the prognostic value of miR-944 in cervical cancer has not been fully investigated. The aim of this study was to analyze clinical significance and prognostic value of miR-944 in cervical cancer. Methods: The expression levels of miR-944 were detected using quantitative reverse transcription polymerase chain reaction in five types of cervical cancer cell lines and 116 formalin-fixed paraffin-embedded (FFPE) cervical tissues. The association between the expression levels of miR-944 and prognostic value was analyzed using the Kaplan-Meier analysis and Cox proportional hazards model. Results: The expression levels of miR-944 in cervical cancer tissues were significantly higher compared with those in normal tissues (P < 0.0001). Moreover, the expression levels of miR-944 in cervical cancer cell lines and FFPE tissues with human papillomavirus (HPV) infection were significantly higher compared to those without HPV infection (P < 0.01 and P = 0.02). High miR-944 expression was also markedly associated with bulky tumor size (P = 0.026), advanced International Federation of Gynecology and Obstetrics (FIGO) stage (P = 0.042), and lymph node metastasis (P = 0.030). In particular, high miR-944 expression group showed shorter overall survival than the low miR-944 expression group in the advanced FIGO stage (84.4% vs. 44.4%, HR = 4.0, and P = 0.01). Conclusions: These results suggest that miR-944 may be used as a novel biomarker for improving prognosis and as a potential therapeutic target.

AB - Background: One-third of cervical cancer patients are still diagnosed at advanced stages. The five-year survival rate is decreased in about 50% of advanced stage cervical cancer patients worldwide, and the clinical outcomes are remarkably varied and difficult to predict. One of the miRNAs known to be associated with cancer tumorigenesis is miR-944. However, the prognostic value of miR-944 in cervical cancer has not been fully investigated. The aim of this study was to analyze clinical significance and prognostic value of miR-944 in cervical cancer. Methods: The expression levels of miR-944 were detected using quantitative reverse transcription polymerase chain reaction in five types of cervical cancer cell lines and 116 formalin-fixed paraffin-embedded (FFPE) cervical tissues. The association between the expression levels of miR-944 and prognostic value was analyzed using the Kaplan-Meier analysis and Cox proportional hazards model. Results: The expression levels of miR-944 in cervical cancer tissues were significantly higher compared with those in normal tissues (P < 0.0001). Moreover, the expression levels of miR-944 in cervical cancer cell lines and FFPE tissues with human papillomavirus (HPV) infection were significantly higher compared to those without HPV infection (P < 0.01 and P = 0.02). High miR-944 expression was also markedly associated with bulky tumor size (P = 0.026), advanced International Federation of Gynecology and Obstetrics (FIGO) stage (P = 0.042), and lymph node metastasis (P = 0.030). In particular, high miR-944 expression group showed shorter overall survival than the low miR-944 expression group in the advanced FIGO stage (84.4% vs. 44.4%, HR = 4.0, and P = 0.01). Conclusions: These results suggest that miR-944 may be used as a novel biomarker for improving prognosis and as a potential therapeutic target.

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MicroRNA-944 overexpression is a biomarker for poor prognosis of advanced cervical cancer

Abstract

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