Microstructure of β-zone parapapillary atrophy and rate of retinal nerve fiber layer thinning in primary open-angle glaucoma

Yong Woo Kim, Eun Ji Lee, Tae Woo Kim, Mijin Kim, Hyunjoong Kim

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Abstract

Objective To investigate whether the rate of retinal nerve fiber layer (RNFL) thinning differs according to the microstructure of β-zone parapapillary atrophy (PPA) as evaluated by spectral-domain (SD) optical coherence tomography (OCT) in primary open-angle glaucoma (POAG). Design Prospective, observational, comparative study. Participants A total of 195 eyes with POAG that had been evaluated by serial SD-OCT RNFL thickness measurements for ≥2 years. Methods On the basis of the extent of Bruch's membrane (BM) within the β-zone PPA (area without retinal pigment epithelium [RPE]), as shown in the infrared fundus images, PPA was divided into PPA+BM (PPA with intact BM) and PPA-BM (PPA devoid of BM). Eyes were categorized into group A (having PPA+BM only, n=64), group B (having both PPA+BM and PPA-BM, n=58), group C (having PPA -BM only, n=32), and group D (without β-zone PPA, n=41). The rate of progressive OCT RNFL thinning was determined by linear regression and compared between groups. Factors influencing the rate of RNFL thinning were evaluated, including age, sex, follow-up duration, history of filtering surgery, baseline RNFL thickness, baseline intraocular pressure (IOP), mean IOP and IOP fluctuation during follow-up, PPA types, baseline PPA width, PPA width increase, axial length (AXL), central corneal thickness, and visual field mean deviation (MD). Main Outcome Measures Rate of thinning of OCT RNFL thicknesses over time. Results Patients in groups B and C were significantly younger and more myopic, and had a greater AXL, than those in groups A and D (all P < 0.001). The rate of global RNFL thinning was significantly faster in group A (-1.66±2.94 μm/year) than in the other groups (group B, -0.87±1.28 μm/year; group C, 0.20±1.86 μm/year; group D, -0.28±1.74 μm/year; P = 0.001). Multivariate regression showed a significant association of shorter follow-up period (P = 0.016), greater baseline global RNFL thickness (P = 0.035), type of β-zone PPA (group A, P = 0.023), and greater baseline PPA+BM width (P = 0.034) with a faster rate of RNFL thinning. Conclusions The rate of RNFL thinning differed according to the microstructure of β-zone PPA. It was faster for eyes with β-zone PPA with intact BM than for eyes without β-zone PPA or with β-zone PPA devoid of BM.

Original languageEnglish
Pages (from-to)1341-1349
Number of pages9
JournalOphthalmology
Volume121
Issue number7
DOIs
Publication statusPublished - 2014 Jan 1

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Nerve Fibers
Atrophy
Bruch Membrane
Optical Coherence Tomography
Intraocular Pressure
Primary Open Angle Glaucoma
Filtering Surgery
Retinal Pigment Epithelium
Visual Fields

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Kim, Yong Woo ; Lee, Eun Ji ; Kim, Tae Woo ; Kim, Mijin ; Kim, Hyunjoong. / Microstructure of β-zone parapapillary atrophy and rate of retinal nerve fiber layer thinning in primary open-angle glaucoma. In: Ophthalmology. 2014 ; Vol. 121, No. 7. pp. 1341-1349.
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abstract = "Objective To investigate whether the rate of retinal nerve fiber layer (RNFL) thinning differs according to the microstructure of β-zone parapapillary atrophy (PPA) as evaluated by spectral-domain (SD) optical coherence tomography (OCT) in primary open-angle glaucoma (POAG). Design Prospective, observational, comparative study. Participants A total of 195 eyes with POAG that had been evaluated by serial SD-OCT RNFL thickness measurements for ≥2 years. Methods On the basis of the extent of Bruch's membrane (BM) within the β-zone PPA (area without retinal pigment epithelium [RPE]), as shown in the infrared fundus images, PPA was divided into PPA+BM (PPA with intact BM) and PPA-BM (PPA devoid of BM). Eyes were categorized into group A (having PPA+BM only, n=64), group B (having both PPA+BM and PPA-BM, n=58), group C (having PPA -BM only, n=32), and group D (without β-zone PPA, n=41). The rate of progressive OCT RNFL thinning was determined by linear regression and compared between groups. Factors influencing the rate of RNFL thinning were evaluated, including age, sex, follow-up duration, history of filtering surgery, baseline RNFL thickness, baseline intraocular pressure (IOP), mean IOP and IOP fluctuation during follow-up, PPA types, baseline PPA width, PPA width increase, axial length (AXL), central corneal thickness, and visual field mean deviation (MD). Main Outcome Measures Rate of thinning of OCT RNFL thicknesses over time. Results Patients in groups B and C were significantly younger and more myopic, and had a greater AXL, than those in groups A and D (all P < 0.001). The rate of global RNFL thinning was significantly faster in group A (-1.66±2.94 μm/year) than in the other groups (group B, -0.87±1.28 μm/year; group C, 0.20±1.86 μm/year; group D, -0.28±1.74 μm/year; P = 0.001). Multivariate regression showed a significant association of shorter follow-up period (P = 0.016), greater baseline global RNFL thickness (P = 0.035), type of β-zone PPA (group A, P = 0.023), and greater baseline PPA+BM width (P = 0.034) with a faster rate of RNFL thinning. Conclusions The rate of RNFL thinning differed according to the microstructure of β-zone PPA. It was faster for eyes with β-zone PPA with intact BM than for eyes without β-zone PPA or with β-zone PPA devoid of BM.",
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Microstructure of β-zone parapapillary atrophy and rate of retinal nerve fiber layer thinning in primary open-angle glaucoma. / Kim, Yong Woo; Lee, Eun Ji; Kim, Tae Woo; Kim, Mijin; Kim, Hyunjoong.

In: Ophthalmology, Vol. 121, No. 7, 01.01.2014, p. 1341-1349.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Microstructure of β-zone parapapillary atrophy and rate of retinal nerve fiber layer thinning in primary open-angle glaucoma

AU - Kim, Yong Woo

AU - Lee, Eun Ji

AU - Kim, Tae Woo

AU - Kim, Mijin

AU - Kim, Hyunjoong

PY - 2014/1/1

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N2 - Objective To investigate whether the rate of retinal nerve fiber layer (RNFL) thinning differs according to the microstructure of β-zone parapapillary atrophy (PPA) as evaluated by spectral-domain (SD) optical coherence tomography (OCT) in primary open-angle glaucoma (POAG). Design Prospective, observational, comparative study. Participants A total of 195 eyes with POAG that had been evaluated by serial SD-OCT RNFL thickness measurements for ≥2 years. Methods On the basis of the extent of Bruch's membrane (BM) within the β-zone PPA (area without retinal pigment epithelium [RPE]), as shown in the infrared fundus images, PPA was divided into PPA+BM (PPA with intact BM) and PPA-BM (PPA devoid of BM). Eyes were categorized into group A (having PPA+BM only, n=64), group B (having both PPA+BM and PPA-BM, n=58), group C (having PPA -BM only, n=32), and group D (without β-zone PPA, n=41). The rate of progressive OCT RNFL thinning was determined by linear regression and compared between groups. Factors influencing the rate of RNFL thinning were evaluated, including age, sex, follow-up duration, history of filtering surgery, baseline RNFL thickness, baseline intraocular pressure (IOP), mean IOP and IOP fluctuation during follow-up, PPA types, baseline PPA width, PPA width increase, axial length (AXL), central corneal thickness, and visual field mean deviation (MD). Main Outcome Measures Rate of thinning of OCT RNFL thicknesses over time. Results Patients in groups B and C were significantly younger and more myopic, and had a greater AXL, than those in groups A and D (all P < 0.001). The rate of global RNFL thinning was significantly faster in group A (-1.66±2.94 μm/year) than in the other groups (group B, -0.87±1.28 μm/year; group C, 0.20±1.86 μm/year; group D, -0.28±1.74 μm/year; P = 0.001). Multivariate regression showed a significant association of shorter follow-up period (P = 0.016), greater baseline global RNFL thickness (P = 0.035), type of β-zone PPA (group A, P = 0.023), and greater baseline PPA+BM width (P = 0.034) with a faster rate of RNFL thinning. Conclusions The rate of RNFL thinning differed according to the microstructure of β-zone PPA. It was faster for eyes with β-zone PPA with intact BM than for eyes without β-zone PPA or with β-zone PPA devoid of BM.

AB - Objective To investigate whether the rate of retinal nerve fiber layer (RNFL) thinning differs according to the microstructure of β-zone parapapillary atrophy (PPA) as evaluated by spectral-domain (SD) optical coherence tomography (OCT) in primary open-angle glaucoma (POAG). Design Prospective, observational, comparative study. Participants A total of 195 eyes with POAG that had been evaluated by serial SD-OCT RNFL thickness measurements for ≥2 years. Methods On the basis of the extent of Bruch's membrane (BM) within the β-zone PPA (area without retinal pigment epithelium [RPE]), as shown in the infrared fundus images, PPA was divided into PPA+BM (PPA with intact BM) and PPA-BM (PPA devoid of BM). Eyes were categorized into group A (having PPA+BM only, n=64), group B (having both PPA+BM and PPA-BM, n=58), group C (having PPA -BM only, n=32), and group D (without β-zone PPA, n=41). The rate of progressive OCT RNFL thinning was determined by linear regression and compared between groups. Factors influencing the rate of RNFL thinning were evaluated, including age, sex, follow-up duration, history of filtering surgery, baseline RNFL thickness, baseline intraocular pressure (IOP), mean IOP and IOP fluctuation during follow-up, PPA types, baseline PPA width, PPA width increase, axial length (AXL), central corneal thickness, and visual field mean deviation (MD). Main Outcome Measures Rate of thinning of OCT RNFL thicknesses over time. Results Patients in groups B and C were significantly younger and more myopic, and had a greater AXL, than those in groups A and D (all P < 0.001). The rate of global RNFL thinning was significantly faster in group A (-1.66±2.94 μm/year) than in the other groups (group B, -0.87±1.28 μm/year; group C, 0.20±1.86 μm/year; group D, -0.28±1.74 μm/year; P = 0.001). Multivariate regression showed a significant association of shorter follow-up period (P = 0.016), greater baseline global RNFL thickness (P = 0.035), type of β-zone PPA (group A, P = 0.023), and greater baseline PPA+BM width (P = 0.034) with a faster rate of RNFL thinning. Conclusions The rate of RNFL thinning differed according to the microstructure of β-zone PPA. It was faster for eyes with β-zone PPA with intact BM than for eyes without β-zone PPA or with β-zone PPA devoid of BM.

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