Microtumor array: 3D tumor spheroid embedding bilayed hydrogel sheet

Junghwa Cha, Hyo Min Kim, Seok Gu Kang, Pilnam Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A small subpopulation of cells within malignant brain tumor, the glioma cancer stem cells (GSCs), have been revealed to be responsible for therapeutic resistance and recurrence. However, proinvasive factors for the aggressive GSCs still remain unknown. Thus, we propose a microtumor array which is based on a bio-inert hydrogel for spontaneous formation of GSC spheroid and a subsequent bio-active hydrogel for observation of GSC invasion within a single system. The microtumor array can be applicable as an evaluation tool for observation of the invasive ability of malignant brain tumors, as well as other systematic cancers.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages811-813
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - 2015 Jan 1
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 2015 Oct 252015 Oct 29

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period15/10/2515/10/29

Fingerprint

Stem cells
Hydrogels
Tumors
Brain
Cells

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Cha, J., Kim, H. M., Kang, S. G., & Kim, P. (2015). Microtumor array: 3D tumor spheroid embedding bilayed hydrogel sheet. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 811-813). (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.
Cha, Junghwa ; Kim, Hyo Min ; Kang, Seok Gu ; Kim, Pilnam. / Microtumor array : 3D tumor spheroid embedding bilayed hydrogel sheet. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. pp. 811-813 (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).
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abstract = "A small subpopulation of cells within malignant brain tumor, the glioma cancer stem cells (GSCs), have been revealed to be responsible for therapeutic resistance and recurrence. However, proinvasive factors for the aggressive GSCs still remain unknown. Thus, we propose a microtumor array which is based on a bio-inert hydrogel for spontaneous formation of GSC spheroid and a subsequent bio-active hydrogel for observation of GSC invasion within a single system. The microtumor array can be applicable as an evaluation tool for observation of the invasive ability of malignant brain tumors, as well as other systematic cancers.",
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Cha, J, Kim, HM, Kang, SG & Kim, P 2015, Microtumor array: 3D tumor spheroid embedding bilayed hydrogel sheet. in MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 811-813, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, Gyeongju, Korea, Republic of, 15/10/25.

Microtumor array : 3D tumor spheroid embedding bilayed hydrogel sheet. / Cha, Junghwa; Kim, Hyo Min; Kang, Seok Gu; Kim, Pilnam.

MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. p. 811-813 (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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N2 - A small subpopulation of cells within malignant brain tumor, the glioma cancer stem cells (GSCs), have been revealed to be responsible for therapeutic resistance and recurrence. However, proinvasive factors for the aggressive GSCs still remain unknown. Thus, we propose a microtumor array which is based on a bio-inert hydrogel for spontaneous formation of GSC spheroid and a subsequent bio-active hydrogel for observation of GSC invasion within a single system. The microtumor array can be applicable as an evaluation tool for observation of the invasive ability of malignant brain tumors, as well as other systematic cancers.

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M3 - Conference contribution

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Cha J, Kim HM, Kang SG, Kim P. Microtumor array: 3D tumor spheroid embedding bilayed hydrogel sheet. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2015. p. 811-813. (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).