A small subpopulation of cells within malignant brain tumor, the glioma cancer stem cells (GSCs), have been revealed to be responsible for therapeutic resistance and recurrence. However, proinvasive factors for the aggressive GSCs still remain unknown. Thus, we propose a microtumor array which is based on a bio-inert hydrogel for spontaneous formation of GSC spheroid and a subsequent bio-active hydrogel for observation of GSC invasion within a single system. The microtumor array can be applicable as an evaluation tool for observation of the invasive ability of malignant brain tumors, as well as other systematic cancers.
|Title of host publication||MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Publisher||Chemical and Biological Microsystems Society|
|Number of pages||3|
|Publication status||Published - 2015|
|Event||19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of|
Duration: 2015 Oct 25 → 2015 Oct 29
|Name||MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Other||19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015|
|Country||Korea, Republic of|
|Period||15/10/25 → 15/10/29|
Bibliographical noteFunding Information:
We gratefully acknowledge support from National Research Foundation (NRF-2014R1A1A1004985) and by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea. (HI13C15090001 and HI14C00420200).
All Science Journal Classification (ASJC) codes
- Control and Systems Engineering