Mid-life and late-life vascular risk factors and dementia in Korean men and women

H. Kimm, P. H. Lee, Y. J. Shin, K. S. Park, J. Jo, Y. Lee, H. C. Kang, S. H. Jee

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Dementia is one of the most important neurological disorders in the elderly population. The significance of vascular risk factors for dementia remains controversial. This study aimed to determine the effects of vascular risk factors, such as blood pressure, diabetes and smoking in the mid-life or the late-life on dementia risk. The data in this prospective cohort study came from 3252 dementia events occurring over 14 years among 848,505 Koreans aged 40-95 years insured by the National Health Insurance Corporation who had a biennial medical evaluation during 1992-1995. Data on clinical dementia during the period 1993-2006 were examined in relation to vascular risk factors. The age adjusted incidence per 100,000 was 31.9 for men and 45.0 for women, respectively. In multivariate Cox proportional hazard models, diabetes increased the risk of either dementia in Alzheimer's disease or vascular dementia in men and women, controlling for age, hypertension, total cholesterol, alcohol drinking, and smoking. Hypertension also increased vascular dementia in both men [Hazard ratio (HR) = 2.6, 95% confidence interval (CI) = 1.7-3.8] and women (HR = 2.3, 95%CI = 1.6-3.3). The association of hypertension or diabetes on risk of vascular dementia, however, among the group aged older than 65 was attenuated but remained as significant in men. There was no interaction between hypertension and diabetes on the risk of dementia. This study demonstrates that diabetes and hypertension increased the risk of vascular dementia. Treatment for these risk factors may reduce the risk of vascular dementia.

Original languageEnglish
Pages (from-to)e117-e122
JournalArchives of Gerontology and Geriatrics
Volume52
Issue number3
DOIs
Publication statusPublished - 2011 May 1

Fingerprint

Vascular Dementia
dementia
Dementia
Hypertension
hypertension
chronic illness
Alzheimer Disease
Smoking
Confidence Intervals
National Health Programs
vascular factor
Nervous System Diseases
Proportional Hazards Models
Alcohol Drinking
smoking
confidence
Cohort Studies
Cholesterol
Prospective Studies
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Kimm, H. ; Lee, P. H. ; Shin, Y. J. ; Park, K. S. ; Jo, J. ; Lee, Y. ; Kang, H. C. ; Jee, S. H. / Mid-life and late-life vascular risk factors and dementia in Korean men and women. In: Archives of Gerontology and Geriatrics. 2011 ; Vol. 52, No. 3. pp. e117-e122.
@article{23130db2f7254cb79804a6114ae46e73,
title = "Mid-life and late-life vascular risk factors and dementia in Korean men and women",
abstract = "Dementia is one of the most important neurological disorders in the elderly population. The significance of vascular risk factors for dementia remains controversial. This study aimed to determine the effects of vascular risk factors, such as blood pressure, diabetes and smoking in the mid-life or the late-life on dementia risk. The data in this prospective cohort study came from 3252 dementia events occurring over 14 years among 848,505 Koreans aged 40-95 years insured by the National Health Insurance Corporation who had a biennial medical evaluation during 1992-1995. Data on clinical dementia during the period 1993-2006 were examined in relation to vascular risk factors. The age adjusted incidence per 100,000 was 31.9 for men and 45.0 for women, respectively. In multivariate Cox proportional hazard models, diabetes increased the risk of either dementia in Alzheimer's disease or vascular dementia in men and women, controlling for age, hypertension, total cholesterol, alcohol drinking, and smoking. Hypertension also increased vascular dementia in both men [Hazard ratio (HR) = 2.6, 95{\%} confidence interval (CI) = 1.7-3.8] and women (HR = 2.3, 95{\%}CI = 1.6-3.3). The association of hypertension or diabetes on risk of vascular dementia, however, among the group aged older than 65 was attenuated but remained as significant in men. There was no interaction between hypertension and diabetes on the risk of dementia. This study demonstrates that diabetes and hypertension increased the risk of vascular dementia. Treatment for these risk factors may reduce the risk of vascular dementia.",
author = "H. Kimm and Lee, {P. H.} and Shin, {Y. J.} and Park, {K. S.} and J. Jo and Y. Lee and Kang, {H. C.} and Jee, {S. H.}",
year = "2011",
month = "5",
day = "1",
doi = "10.1016/j.archger.2010.09.004",
language = "English",
volume = "52",
pages = "e117--e122",
journal = "Archives of Gerontology and Geriatrics",
issn = "0167-4943",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

Mid-life and late-life vascular risk factors and dementia in Korean men and women. / Kimm, H.; Lee, P. H.; Shin, Y. J.; Park, K. S.; Jo, J.; Lee, Y.; Kang, H. C.; Jee, S. H.

In: Archives of Gerontology and Geriatrics, Vol. 52, No. 3, 01.05.2011, p. e117-e122.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mid-life and late-life vascular risk factors and dementia in Korean men and women

AU - Kimm, H.

AU - Lee, P. H.

AU - Shin, Y. J.

AU - Park, K. S.

AU - Jo, J.

AU - Lee, Y.

AU - Kang, H. C.

AU - Jee, S. H.

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Dementia is one of the most important neurological disorders in the elderly population. The significance of vascular risk factors for dementia remains controversial. This study aimed to determine the effects of vascular risk factors, such as blood pressure, diabetes and smoking in the mid-life or the late-life on dementia risk. The data in this prospective cohort study came from 3252 dementia events occurring over 14 years among 848,505 Koreans aged 40-95 years insured by the National Health Insurance Corporation who had a biennial medical evaluation during 1992-1995. Data on clinical dementia during the period 1993-2006 were examined in relation to vascular risk factors. The age adjusted incidence per 100,000 was 31.9 for men and 45.0 for women, respectively. In multivariate Cox proportional hazard models, diabetes increased the risk of either dementia in Alzheimer's disease or vascular dementia in men and women, controlling for age, hypertension, total cholesterol, alcohol drinking, and smoking. Hypertension also increased vascular dementia in both men [Hazard ratio (HR) = 2.6, 95% confidence interval (CI) = 1.7-3.8] and women (HR = 2.3, 95%CI = 1.6-3.3). The association of hypertension or diabetes on risk of vascular dementia, however, among the group aged older than 65 was attenuated but remained as significant in men. There was no interaction between hypertension and diabetes on the risk of dementia. This study demonstrates that diabetes and hypertension increased the risk of vascular dementia. Treatment for these risk factors may reduce the risk of vascular dementia.

AB - Dementia is one of the most important neurological disorders in the elderly population. The significance of vascular risk factors for dementia remains controversial. This study aimed to determine the effects of vascular risk factors, such as blood pressure, diabetes and smoking in the mid-life or the late-life on dementia risk. The data in this prospective cohort study came from 3252 dementia events occurring over 14 years among 848,505 Koreans aged 40-95 years insured by the National Health Insurance Corporation who had a biennial medical evaluation during 1992-1995. Data on clinical dementia during the period 1993-2006 were examined in relation to vascular risk factors. The age adjusted incidence per 100,000 was 31.9 for men and 45.0 for women, respectively. In multivariate Cox proportional hazard models, diabetes increased the risk of either dementia in Alzheimer's disease or vascular dementia in men and women, controlling for age, hypertension, total cholesterol, alcohol drinking, and smoking. Hypertension also increased vascular dementia in both men [Hazard ratio (HR) = 2.6, 95% confidence interval (CI) = 1.7-3.8] and women (HR = 2.3, 95%CI = 1.6-3.3). The association of hypertension or diabetes on risk of vascular dementia, however, among the group aged older than 65 was attenuated but remained as significant in men. There was no interaction between hypertension and diabetes on the risk of dementia. This study demonstrates that diabetes and hypertension increased the risk of vascular dementia. Treatment for these risk factors may reduce the risk of vascular dementia.

UR - http://www.scopus.com/inward/record.url?scp=79953087183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953087183&partnerID=8YFLogxK

U2 - 10.1016/j.archger.2010.09.004

DO - 10.1016/j.archger.2010.09.004

M3 - Article

C2 - 20932588

AN - SCOPUS:79953087183

VL - 52

SP - e117-e122

JO - Archives of Gerontology and Geriatrics

JF - Archives of Gerontology and Geriatrics

SN - 0167-4943

IS - 3

ER -