Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization

doyoung kim, Moon Seok Choi, Joon Hyoek Lee, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo, Sung Wook Shin, Sung Wook Choo, Young Soo Do, Jong Chul Rhee

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15 Citations (Scopus)

Abstract

Aim: To evaluate whether the Milan criteria are useful in patients with hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) before liver transplantation (LT). Methods: Thirty-six HCC patients who fulfilled the Milan criteria after having received TACE and subsequently underwent LT were included (TACE + LT group) in the study. As controls, 21 patients who also met the Milan criteria and underwent LT without prior treatment were selected (LT group). Post-LT clinical outcomes, such as HCC recurrence, survival rate, and histologic features of explanted livers, were compared between the two groups. Results: Baseline characteristics were not different between the two groups. Pre-LT maximal tumor diameter in TACE + LT group was similar to that of LT group (2.0 ± 0.6 cm vs 2.3 ± 0.9 cm; P = 0.10). Post-LT histologic findings also revealed similar maximal tumor diameter in the two groups (2.4 ± 1.4 cm vs 2.3 ± 0.9 cm; P = 0.70). Explanted livers showed similar incidence of unfavorable pathologic features. The morality within 60 d after transplantation was not different between the two groups (8.3% vs 9.5%; P = 0.99). Post-LT 5-year survival rate (57% vs 74%; P = 0.70) and cumulative recurrence rate (8.3% vs 4.8%; P = 0.90) were not significantly different between the two groups. Conclusion: The Milan criteria are still a useful selection criteria showing favorable outcomes in HCC patients receiving TACE before LT.

Original languageEnglish
Pages (from-to)6992-6997
Number of pages6
JournalWorld Journal of Gastroenterology
Volume12
Issue number43
DOIs
Publication statusPublished - 2006 Nov 21

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Liver Transplantation
Hepatocellular Carcinoma
Survival Rate
Recurrence
Liver
Patient Selection
Neoplasms
Transplantation

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

kim, doyoung ; Choi, Moon Seok ; Lee, Joon Hyoek ; Koh, Kwang Cheol ; Paik, Seung Woon ; Yoo, Byung Chul ; Shin, Sung Wook ; Choo, Sung Wook ; Do, Young Soo ; Rhee, Jong Chul. / Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization. In: World Journal of Gastroenterology. 2006 ; Vol. 12, No. 43. pp. 6992-6997.
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title = "Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization",
abstract = "Aim: To evaluate whether the Milan criteria are useful in patients with hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) before liver transplantation (LT). Methods: Thirty-six HCC patients who fulfilled the Milan criteria after having received TACE and subsequently underwent LT were included (TACE + LT group) in the study. As controls, 21 patients who also met the Milan criteria and underwent LT without prior treatment were selected (LT group). Post-LT clinical outcomes, such as HCC recurrence, survival rate, and histologic features of explanted livers, were compared between the two groups. Results: Baseline characteristics were not different between the two groups. Pre-LT maximal tumor diameter in TACE + LT group was similar to that of LT group (2.0 ± 0.6 cm vs 2.3 ± 0.9 cm; P = 0.10). Post-LT histologic findings also revealed similar maximal tumor diameter in the two groups (2.4 ± 1.4 cm vs 2.3 ± 0.9 cm; P = 0.70). Explanted livers showed similar incidence of unfavorable pathologic features. The morality within 60 d after transplantation was not different between the two groups (8.3{\%} vs 9.5{\%}; P = 0.99). Post-LT 5-year survival rate (57{\%} vs 74{\%}; P = 0.70) and cumulative recurrence rate (8.3{\%} vs 4.8{\%}; P = 0.90) were not significantly different between the two groups. Conclusion: The Milan criteria are still a useful selection criteria showing favorable outcomes in HCC patients receiving TACE before LT.",
author = "doyoung kim and Choi, {Moon Seok} and Lee, {Joon Hyoek} and Koh, {Kwang Cheol} and Paik, {Seung Woon} and Yoo, {Byung Chul} and Shin, {Sung Wook} and Choo, {Sung Wook} and Do, {Young Soo} and Rhee, {Jong Chul}",
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Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization. / kim, doyoung; Choi, Moon Seok; Lee, Joon Hyoek; Koh, Kwang Cheol; Paik, Seung Woon; Yoo, Byung Chul; Shin, Sung Wook; Choo, Sung Wook; Do, Young Soo; Rhee, Jong Chul.

In: World Journal of Gastroenterology, Vol. 12, No. 43, 21.11.2006, p. 6992-6997.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization

AU - kim, doyoung

AU - Choi, Moon Seok

AU - Lee, Joon Hyoek

AU - Koh, Kwang Cheol

AU - Paik, Seung Woon

AU - Yoo, Byung Chul

AU - Shin, Sung Wook

AU - Choo, Sung Wook

AU - Do, Young Soo

AU - Rhee, Jong Chul

PY - 2006/11/21

Y1 - 2006/11/21

N2 - Aim: To evaluate whether the Milan criteria are useful in patients with hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) before liver transplantation (LT). Methods: Thirty-six HCC patients who fulfilled the Milan criteria after having received TACE and subsequently underwent LT were included (TACE + LT group) in the study. As controls, 21 patients who also met the Milan criteria and underwent LT without prior treatment were selected (LT group). Post-LT clinical outcomes, such as HCC recurrence, survival rate, and histologic features of explanted livers, were compared between the two groups. Results: Baseline characteristics were not different between the two groups. Pre-LT maximal tumor diameter in TACE + LT group was similar to that of LT group (2.0 ± 0.6 cm vs 2.3 ± 0.9 cm; P = 0.10). Post-LT histologic findings also revealed similar maximal tumor diameter in the two groups (2.4 ± 1.4 cm vs 2.3 ± 0.9 cm; P = 0.70). Explanted livers showed similar incidence of unfavorable pathologic features. The morality within 60 d after transplantation was not different between the two groups (8.3% vs 9.5%; P = 0.99). Post-LT 5-year survival rate (57% vs 74%; P = 0.70) and cumulative recurrence rate (8.3% vs 4.8%; P = 0.90) were not significantly different between the two groups. Conclusion: The Milan criteria are still a useful selection criteria showing favorable outcomes in HCC patients receiving TACE before LT.

AB - Aim: To evaluate whether the Milan criteria are useful in patients with hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) before liver transplantation (LT). Methods: Thirty-six HCC patients who fulfilled the Milan criteria after having received TACE and subsequently underwent LT were included (TACE + LT group) in the study. As controls, 21 patients who also met the Milan criteria and underwent LT without prior treatment were selected (LT group). Post-LT clinical outcomes, such as HCC recurrence, survival rate, and histologic features of explanted livers, were compared between the two groups. Results: Baseline characteristics were not different between the two groups. Pre-LT maximal tumor diameter in TACE + LT group was similar to that of LT group (2.0 ± 0.6 cm vs 2.3 ± 0.9 cm; P = 0.10). Post-LT histologic findings also revealed similar maximal tumor diameter in the two groups (2.4 ± 1.4 cm vs 2.3 ± 0.9 cm; P = 0.70). Explanted livers showed similar incidence of unfavorable pathologic features. The morality within 60 d after transplantation was not different between the two groups (8.3% vs 9.5%; P = 0.99). Post-LT 5-year survival rate (57% vs 74%; P = 0.70) and cumulative recurrence rate (8.3% vs 4.8%; P = 0.90) were not significantly different between the two groups. Conclusion: The Milan criteria are still a useful selection criteria showing favorable outcomes in HCC patients receiving TACE before LT.

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